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Commercializing biotechnology in China

I recently had the opportunity to conduct a brief interview with Mireille Gingras, Ph.D. President and CEO of HUYA Bioscience on doing business with and in China:

Tell me about HUYA and what makes the company unique?
HUYA Bioscience International has pioneered the most innovative and productive approach for pharmaceutical co-development between the U.S. and China. We were one of the first companies to recognize the potential of China as a source for novel preclinical and clinical stage compounds. Through our partnerships with Chinese companies and institutes, HUYA can use preclinical and clinical stage data generated in China to guide drug development process in the West. Even though clinical trials must still be completed in the West, the process is streamlined, and risks are minimized because HUYA’s Western pharmaceutical partners will have access to critical data from China. Simultaneously, HUYA provides significant development assistance to our Chinese partners. As a result, I anticipate that HUYA will source compounds in China that may become important drugs globally.

What led you to target China as a source for compounds?
There is an urgent need in the global pharmaceutical industry for fresh new sources of novel compounds. As a licensing consultant for pharmaceutical and biotech companies, I was seeking to find novel preclinical and early clinical-stage compounds in Europe and Asia. Many of us were looking in the same places and the pools of novel compounds were depleted. I subsequently spent time in China meeting with heads of government research institutions, biotechnology parks, incubators and pharmaceutical companies. In China, I recognized that there were untapped and significant opportunities for drug discovery and development. To leverage these opportunities, I formed HUYA Bioscience International. HUYA’s business model, the Integrated Co-Development model (ICM), is designed to reduce the risk and cost of drug development in the U.S. by providing a framework for sourcing, licensing and developing validated, preclinical and clinical stage compounds from China. We currently have two compounds licensed from China that are in preclinical development in the U.S., thus validating our model.

What are the unique challenges/opportunities to developing compounds sourced from China?
One challenge, of course, is the language difference. We must have bilingual staff in both the US and China so that we are confident that our due diligence is performed with the utmost attention to detail. Another challenge is that I must spend a significant amount of time in China. This is crucial for developing trust, forging partnership agreements and licensing compounds. HUYA has the “first mover” advantage in China, having been there now for four years and developing critical personal relationships with the heads of the Chinese research institutions and pharmaceutical companies. The Chinese seem to prefer to do business with people they trust and with whom they have long-standing relationships. No other company has the breadth and depth of relationships that HUYA has developed in the Chinese research community.

Because of these relationships, we are able to take advantage of the enormous opportunities presented by China’s large community of world-class scientists, many of whom were educated in the U.S. and have returned to China to develop their careers. We are also able to draw from the well-established scientific infrastructure in China of research institutes, bioparks, and pharmaceutical companies that provides one of the world’s richest sources for novel compounds.

We have a truly unique opportunity to lower the risks and costs of Western drug development by providing access to data from the Chinese development process. Of course, all of the compounds that are developed in the U.S. will have to go through the same rigorous FDA process that they would have gone through had they been sourced from the U.S., including animal and human trials. But, this process is streamlined, and the risks are minimized because HUYA’s U.S. pharmaceutical partners will have access to critical data from our Chinese partners. For example, a U.S. pharmaceutical company that takes on one of the new compounds has access to efficacy, toxicology, and dosing data from Chinese clinical trials, so the trial is not started from scratch, but can be designed based on the information gathered through the Chinese trial. In addition, the Chinese clinical trial data can be used as supporting data to the FDA process here in the U.S.

For each promising new compound in development, HUYA assembles a world-class team of clinical advisors to direct the clinical trials and ensure that they meet U.S. FDA standards. In addition, because HUYA’s model is to co-develop compounds with our Chinese partners, we can help our Chinese partners design trials in China that will inform our trials in the U.S.

About Mireille Gingras, PhD, CEO and President of HUYA Bioscience International
Mireille is a seasoned entrepreneur, scientist and consultant with wide ranging experience in drug discovery, licensing programs (both in- and out-license), preclinical research design and academic partnering programs for top pharmaceutical and biotechnology companies including Organon, Cypress Bioscience, Phenomix, and GeminX. She has made major contributions to the study of complex addictive diseases, and has led research and drug development efforts in the areas of neuroactive steroids, and neurological and neurodegenerative diseases. Through her extensive work in China with HUYA, Mireille has developed unrivaled expertise in partnering with Chinese research institutions and pharmaceutical companies and building bridges into the Western development process.

About HUYA Bioscience International
The global pharmaceutical industry faces an urgent need for fresh new sources of novel compounds. HUYA Bioscience International, LLC, was one of the first companies to recognize China’s potential to help meet this need through its burgeoning biotechnology industry and world class talent pool. HUYA pioneered an innovative co-development model through which it identifies and licenses the most promising preclinical and clinical stage compounds in China, partners with Chinese research institutions to leverage and extend their research efforts, and provides a bridge into the U.S. development process and the Western biopharma market. Because the compounds have already been validated through a rigorous discovery, selection and development process in China, this model streamlines and accelerates product development in the West, while lowering risk. HUYA is now the leader in U.S./China pharmaceutical co-development, with three strategic offices in China, the broadest Chinese compound portfolio, and more exclusive agreements with premier Chinese biotech centers than any other company. HUYA has joint headquarters in San Diego, California, and Shanghai, China.

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  1. Dear Dr. Gingras,

    I have been a physician for a long period. I have conducted an investigation and have learned the cause of many idiopathic diseases including peripheral neuropathies, central neuropathies, arteriosclerosis, cancer, and others. I realize my claim sounds pompous, but like most things, it is simple once the principles are “figured out”.

    I am looking for a “place to further prove my theory” and then develop and manufacture the autoantibody blocking agents to control the underlying autoimmune disease that causes the target-organ manifestations, typically thought to be diseases.

    I determined the nature of the microorganism that triggers the disease process, essentially.

    If you have interest in learning more contact me on my e-mail site.

    I have been in the USMC, in Vietnam as a pilot and also worked in Japan for a year. I have been in Taiwan, but not mainland China. I would like to work there though.

    I owned three clinics at one time, but now I am semi-retired and doing academic research to reinforce the clinical investigation I did over a three year period. I will attach a paper if I can.

    A Unifying Theory of Diseases,

    Autoimmune-Disease and Target-Organ Manifestations

    I am a general practitioner in medicine, and I have, I am sure, developed a meaningful insight into the cause of many, heretofore, idiopathic diseases. Idiopathic diseases have been described with increasing frequency during the last sixty years after most of the infectious diseases were understood and controlled with antibiotics by the first half of the 1900’s. Now, medical texts have become filled with the descriptions of thousands of idiopathic diseases, those diseases with no known cause, and since their causes are not known the treatments for them are disease altering not disease curing.

    Surprisingly, most idiopathic diseases are target-organ manifestation of a systemic, inflammatory, autoimmune-disease process. The autoimmune-disease is caused by an inflammatory, autoimmune condition, which is itself caused or triggered by an infection by a microorganism. It is a microorganism that is quite common and it is ubiquitous to populations of vertebrates, which includes domestic animals and humans. With that in mind, a person can consider the disease a bilateral zooinosis.

    Some target-organ manifestations of the autoimmune disease process are commonly noted dermatologically. Medical observers do not usually think that dermatological features such as nevi, thinning of the skin and wrinkle formation, seborrheic keratosis, angiomas, seborrheic dermatitis, eczema, poliosis, graying of the hair, etc. are necessarily pathological in nature. Often they are thought to be a part of the aging process. If, however, a person develops coronary artery disease, cancer, glaucoma, gall stones, a rheumatoid disease or diabetes, as they get older, and the problem can be localized to a certain organ by a procedurally trained specialist, is thought to be a specific disease wherein it is really a target-organ manifestation of the systemic, autoimmune-mediated disease process.

    I, working as a general practitioner, determined that most idiopathic diseases are target-organ manifestations of a systemic, inflammatory autoimmune disease process. By having a different educational background (part of it in aviation systems analysis) and clinical approach to medicine, and by treating males and females, of all ages, for all diseases, I was able to have insights that led to a new philosophy of disease development, one that explains the cause of most idiopathic diseases including many dermatological conditions, gastrointestinal diseases, neurological diseases, cancer, arteriosclerosis, the rheumatoid diseases, and endocrine diseases, which together, can be conceived to be a great part of the process of aging.

    I saw over 230,000 patient visits, including 1000 house calls, in a poor, semi-rural logging community with no modern industry. Over a long period of time I noted certain combinations of diseases within members of families for up to four generations. Due to that phenomenon, and due to the frequency of MS and peripheral neuropathies in my community, I decided to do a clinical and epidemiological investigation. The information in the following pages explains my search, some of my findings, and some things that are appropriate in the future. I have not mentioned the identification of the microorganism that triggers the autoimmune response since that information is my proprietary knowledge at this time. Thanks for reading this long letter/paper, in advance.

    I have been a military and civilian physician for thirty-one years, a clinical medical theoretician for the last three years of my practice period, and an academic investigator for the last three years.

    Some sciences have experienced quantum breakthroughs in the past, for instance, physics (pun intended), physical chemistry, astronomy and cosmology, laser science, immunology and perhaps even the insights that led to the transistor and digital computer-code concepts, which thereafter led to the “computer revolution”. Medicine, as a scientific endeavor, has experienced many breakthroughs historically, but none of a theoretical nature that describes the causes of diseases since the late 1700’s or perhaps the early 1800’s, when the hypothesis and then the theory developed that microorganisms could cause disease. That discovery led to the insight, which resulted in the development of antibiotics in the 1930’s and 1940’s. That discovery was probably the last major breakthrough in medicine!

    As you know, diagnostic and treatment efforts have been developed during the last sixty years, by borrowing from other high-tech fields such as electronics, laser science, ultrasound, biochemistry, and computer engineering, but not from insights determined directly from theoretical medicine, which could provide a direct approach to the nature of disease development and therefore its treatment. There are many high-tech devices to help minimize the affects of disease on a certain organ or to help make a more definite diagnosis, but yet again, the affects of diseases are being altered and they are not being scientifically approached by first determining their causes.

    The development of the science of genetics, stem-cell concepts, and other new concepts in biology, spawned the idea that using such meaningful and often complex discoveries will lead to a new treatment for “this or that disease” even if the cause of the disease is not known. There always seems to be a new “cause celebre’” in medicine.

    During the last three years of my practice-period, I conducted an epidemiological, clinical investigation, and thereafter, I have conducted a two year epidemiological, academic and historical medical research project, the data from which, overwhelmingly supports my theory. Over a nine-month period I traveled to nine countries and visited clinics and hospitals and talked to and examined people I met at the various locales. I have assured myself that the microbial infection and the autoimmune disease that it triggers, which causes many types of end-organ manifestations, including cancer, arteriosclerosis, birth defects, and the rheumatoid diseases, for instance, is one that exists throughout the world, as I had theorized, but of course it is more serious in certain locales in the world than others.

    Part of my thinking processes involved insights that occurred during the long history of medicine and how the medical concepts of disease formation and the treatments for them have evolved through time. As you well know, infectious diseases caused great health problems for mankind for untold centuries, but the emergence of microbiology and then the discovery of hygienic techniques and antibiotics, in the mid-1800’s to mid-1900’s, decreased the frequency and importance of infectious diseases. Before the period mentioned, even diseases caused by microorganisms were idiopathic in nature.

    Since the 1930’s, when antibiotics were first used clinically, medical texts have “become dominated” by descriptions of conditions that are really idiopathic diseases: cancer, peripheral neuropathies, arteriosclerosis, the various rheumatoid diseases, the various endocrine diseases, osteoporosis, Alzheimer’s disease, Parkinson’s disease, autism, ADHD, PTSD, fibromyalgia and many more diseases of this type. These, and probably 2000 additional idiopathic diseases, are categorized within medical texts, such as “Harrison’s Principles of Internal Medicine” and being idiopathic, there is no known cause for any of them. If the causes of diseases are not known, treatments are disease altering, not disease curing, most of the time. As an example of this situation, it is common to remove a person’s gall bladder due to inflammation, but surgeons rarely ask why the gall bladder was inflamed in the first place! Patients with MS have markers of inflammation, and calcific deposits in the central nervous system, but rarely do practicing neurologists seriously attempt to determine the cause of MS. Patients who have cancer often have neurological pain, but no one knows why they have such pain. Patients with AIDS frequently get rheumatic conditions, neuropathies, infections and cancer, but little is known why they all exist in that subset of patients.

    I have determined the cause, one underlying systemic cause, for most of the idiopathic diseases, and I have provided a description of my discovery, below. One might say that I have discovered a unifying theory of idiopathic diseases, for it would be statistically unusual, and maybe impossible, for there to be 2000 causes for the 2000, or more, diseases that fill medical texts and with which physicians and medical investigators deal with, and are puzzled by, daily.

    I have been a general practice physician, both in the US Navy and in civilian life for nearly thirty years, but over the last six years, the best description of my activities is that I have worked as a theoretical, medical investigator. I was a jet pilot in the US Marine Corps, surprisingly, during my late twenties and early thirties, and then, since I originally had a degree in biology from Whitman College, I re-educated myself, by taking pre-medicine studies at the University of Washington and medical school at the Chicago College of Osteopathic Medicine, into a medical career. I practiced medicine in the Navy as a general medical officer/flight surgeon for five years during active duty and for five years as a reservist. For twenty-three years, thereafter, I was a small-town general practitioner. I always worked mentally in an effort to determine the causes of diseases, since I thought part of my duty as physician was to be a physician-investigator, as well as a being a diagnostician and treating physician.

    I practiced in a semi-rural area of southwest Washington for over twenty years. I was a minor entrepreneur in medicine, for I developed three clinics and had three physician assistants helping me, but I personally saw most of the serious disease cases. I had a total enrollment of 7000 patients in my clinics, so I had a great volume of cases. I prided myself, after I had a number of years of experience, in treating all kinds of medical problems, for both males and females, of all ages, and not acting as a conveyor and send patients with meaningful diseases to specialists. Naturally, I referred patients to specialists for major surgery, internal scoping, imaging procedures, and ICU hospitalization since I practiced too far from a hospital to have such a practice. Such an experience in medicine is not common nowadays, since for fifty or more years medicine has been fragmented into artificial procedural, age-defined, organ oriented, system-related, disease related, and politically determined (family practice) specialties.

    After seeing patients about twenty-five years I became somewhat introspective and realized that unless a patient had had a sprain, a laceration, or a fracture, or unless they had had an infection, nearly all the rest of the medical problems patients experienced were idiopathic (their causes are not known!). I realized that most treatments for idiopathic conditions had been developed by trial and error methods through the ages and the modern version of those efforts are the “clinical trials” of which you are, no doubt, highly familiar. There were situations wherein treating the above conditions, lacerations, fractures, sprains, and infections, were complicated. Slow healing of lacerations or surgical sites with the formation of incisional hernias, keloid development (large scars) and internal adhesions was common. The non-union or delayed-union of fractures, and sprains that caused chronic pain and swelling for months and sometimes years occurred somewhat frequently. At times, another “idiopathic disease name” was applied to explain patient’s chronic pain: reflex sympathetic dystrophy or complex regional pain syndrome. No sure explanation for the cause of these syndromes had ever been given, accurately, in medical texts. Also, some infections are very difficult to treat even with existing antibiotics. There seemed to be something occult going on.

    I worked in a logging and millwork area. I practiced in the small town of Toledo, Washington after I was a Navy physician, because the owner, who had had cardiac by-pass surgery wanted to retire and he “sold-out” to me for nothing down. I wanted to be a little isolated from “specialty medicine” because I did not want be, simply, a patient conveyor as I had been in the Navy. Well, I surely was not a conveyor and I was busy from the first day wherein I saw forty-six patients in a 12 hour shift. I worked nearly as steady for 21 years.

    During the last five or six years I decided that neurological lumbar and cervical spinal pain was not, most of the time, caused by herniated spinal discs. It was rare that a patient improved, in a reasonable time, after lumbar or cervical spinal surgery! I treated many, many cases through the years. I decided to do an epidemiological, clinical investigation and try to find out the “true cause” for lumbar/buttock pain and neuropathy to the lower extremity and shoulder/neck pain and neuropathy to the upper extremity. Little did I know that I was involving myself in a many year project!

    Over a two and one-half year period I attracted nearly 700 miserable, painful patients due to the severe peripheral neuropathy from which they suffered. One might consider them to be the “worst end of the bell-shaped curve”. Many of the patients, probably 40% had had spinal surgery and some patients suffered many, many surgeries. A woman patient had had four cervical surgeries and three lumbar surgeries performed by the same neurosurgeon! She was no better for her experiences. One man had had experienced eight lumbar surgeries and was not any better, either. It was common to have neurological problems in one lower and one upper extremity and at times in all four extremities. It was somewhat common for many members in a given family to have neurologically caused lower or upper back pain! It seemed that there was a systemic, somewhat contagious, occult, disease process going on, but somehow it localized in the nerves of the lumbar/buttock and the shoulder/cervical area.

    During my clinical, epidemiological investigation, I used the techniques any physician could use. I did physical examinations and analytic, neurological physical examinations on my patients, but I used them intensely and repeatedly. I did personal and family medical histories intensely and repeatedly, also. I determined that the neurological problems were located deep in the buttock and shoulder, and not in the spine! I realized that pain is just one manifestation of inflammation (dolor, rubor, tumor, calor = from medicine 101), but I did not know what caused the inflammation.

    I realized that these severely painful patients had similar dermatological abnormalities, and most had some kind of rheumatological malady. Rheumatoid arthritis, a history of juvenile rheumatoid arthritis, lupus erythematosis, scleraderma, Wegener’s granulomatosis, Sjorgen’s syndrome, mixed connective tissue disease, ankylosing spondylitis, and psoriasis, were all represented within the group. Naturally, mild rheumatoid arthritis was the most common. I realized that these diseases were all inflammatory and autoimmune in nature.

    Many patients had an endocrine condition: hypothyroidism, hypoparathyroidism, Addison’s disease, Cushing’s syndrome, diabetes, pituitary, testicular and ovarian abnormalities were common. I realized that many of these diseases were also autoimmune in nature.

    I did a search of medical literature and found the malady of autoimmune-mediated neuropathy. I realized that my patients had that problem: autoimmune-mediated, vasculitic neuropathy. The findings came from the Mayo Clinic Peripheral Nerve Group and Weill Medical College, which is a part of Cornell University.

    Eventually, I learned how the autoimmune-mediated vasculitic neuropathy could be traumatically exacerbated, locally, and caused the somewhat-focused pain deep in the lumbosacral/ buttock area and the shoulder/cervical area. The pathology was not located in the lumbar or cervical spine, as I mentioned above, whereat surgical procedures are focused, but referred pain patterns made the pain radiate into those spinal areas. There are a few herniated discs I suppose, but not many. Surgery for them, however, is quite common! With a touch of sarcasm I will say that some time ago, well-meaning and reputable physicians bled patients for all kinds of problems, too.

    As I kept on working on the problem, I attracted more and more patients, and eventually I realized that many patients had had or developed cancer while I was seeing them. Seventy, out of seven hundred, miserable, painful, patients who came to see me due to chronic painful neuropathies, had had or developed cancer. The average age was about 43, or so, and all types of cancers were represented, but of course, the most common kinds such as breast, cervical, skin, and colon were the most common.

    Some patients had had many cases of cancer. One woman who was born in Manitoba, who I interviewed where she lived on Vancouver Island, had had four major cancers and I noted that she had a squamous cell carcinoma on her face during my first interview. She had had cervical cancer, breast cancer, colon cancer, and then another breast cancer, and squamous cell cancer, over a thirty-year period. There is no way a person could develop five cancers unless there was an underlying disease process stimulating the pathological, somatic, genetic changes. I learned that she became severely ill with an infectious disease at the hospital where she was born and was not expected to live. She was “tagged” with an autoimmune disease nearly from birth and developed the five cancers secondary to the autoimmune, inflammatory assault during her lifetime!

    Another woman, who was in chronic pain for previously diagnosed fibromyalgia developed a sarcoma on her anticubital fossa (anterior side of the elbow) as I was seeing her. Another woman had developed Paget’s breast cancer and chronic lymphocytic leukemia, over a three-year period. The patient with Wegener’s granulomatosis developed leukemia and she had had cervical cancer earlier in her life. The man with ankylosing spondylitis had a large basal cell carcinoma on his nose. A man who had chronic sciatic back pain, and also ulcerative colitis, which is known to be autoimmune in nature, developed colon cancer.

    One man who was in his upper seventies had been my patient for twenty-one years. He was sick when he was a small boy and was severely sick when he was in the US Navy at the end of WW II. He had had a CABG in his early fifties when it was a new procedure. He developed Guillian-Barre’ syndrome before I met him. He had an abdominal aneurysm that had been monitored for size. He had had back pain many times in his life. He developed a mesothelioma, a cancerous lesion with a pleural membrane source, in the lungs. He developed a pneumonia-like disease and thereafter developed renal failure and died. There is a reason for all of the medical conditions the above patients had had or developed: an underlying, inflammatory, autoimmune disease triggered by a certain reasonably-common microorganism.

    A man had had back pain frequently in his life, and he had developed many, many skin cancers on his face, ears, and hands through the years. I did quite a bit of surgery removing them, from time to time, for many years. His wife had ulcerative colitis and severe femoral neuropathy. His son had chronic back pain (sciatica), that is, sacral plexus neuropathy. The man developed an infectious disease and I treated him at home. He was an old-time logger and didn’t want to go to the hospital. Eventually he died of congestive heart failure. How could that have happened? Eventually all the puzzles, including the involvement of family members would be solved!

    I worked and worked intensely, 12-14 hours a day for two and one-half years trying to “break the code”, so to speak, on this systemic disease process. Eventually I had a patient who moved here from Plano, Texas. She said she had fibromyalgia. She arrived taking Oxycontin 20 mg twice a day and Roxicet for breakthrough pain (Oh, crumb, another chronic pain patient!). Many of my other patients had had the same diagnosis before they came to my office. I never used the term fibromyalgia, because the anatomy and pathology of the disease had never been described accurately and the name reflected a symptom complex, only. On about the forth, monthly visit with the above patient, I realized she had the same dermatological abnormalities that many of my other patients who experienced neurological pain exhibited. I asked her when they appeared. She said they appeared when she contracted a certain infectious disease. I was incredulous. I had never treated that disease in my life! I went into my office and reviewed the disease in my texts, since I had not read about it since medical school. I then asked her what her symptoms and signs had been. Her description was perfect, right out of the text! Further research indicated that the microorganism causing the disease could possibly cause an autoimmune stimulation. Now, after a few years of academic research, I know it can cause autoimmune responses of many types and the various sub-types of the microorganism can probably cause different and specific autoimmune responses. Perhaps that variability is one of the reasons why endocrine and rheumatoid diseases have the clinical and serological variables that they do.

    I did serological tests on the above woman and they were highly positive. I did serological tests on one-hundred, or so, other patients (those who could afford it) and a total of seventy were positive. I realized that the “normal” levels published by laboratories were skewed too high, because more people had the infectious disease than knew it and answered incorrectly on medical history forms when their blood was drawn, from which, the normal titers were determined! I interviewed the seven hundred patients as they came into my clinic monthly and many of them knew they had had an infection similar to that which I described when they were young or later in life. Many times their sickness was confused with the worst chicken pox, flu, mononucleosis, viral meningitis or measles that any one ever had had. It tended to be “within families” and I had families in my group of 700 wherein all members had had the infectious/autoimmune disease and the sequela to it. I learned clinically, and then from older medical literature, that the infectious disease and therefore the autoimmune response could be sub-acute or even chronic and last months and years. Even the carrier state, I think, can cause an autoimmune response!

    Now, after two and one-half years, I finally I had a good mental grasp of the microorganism and the disease it causes and also the inflammatory, chronic autoimmune disease that followed persistently, that presents itself in a delayed fashion, initially as an autoimmune vasculitis. I learned how it could cause neuropathy, the rheumatoid diseases, cancer, arteriosclerosis, endocrine diseases, gastrointestinal diseases, dermatological diseases, somatic conditions, pulmonary diseases, including asthma and COPD, and many psychological and neurological conditions such as peripheral neuropathies, MS, probably ALS, autism, ADHD, PTSD, and others. Last year I discovered a book, “The Autoimmune Diseases” ( Rose and McKay, Elsevier Academic Press, 2006), and therein many of the “diseases” that I had discovered to be autoimmune in nature were also categorized as such in the text. Many, many facts, which are presented in texts like “Harrison’s Principles of Internal Medicine” and the prior text, give support to my theory. I do not think there are any conflicts. In the latter text, “Harrison’s”, one has to “go through the specialties” to glean out the relationships, but that is something a generalist in medicine, like I, have done for thirty years.

    I have determined that the inflammatory autoimmune disease, stimulated by the microorganism in question, causes many of the physical and physiological changes that are thought to be the aging process. If a person gets cancer early in life, they had the infectious disease and the autoimmune response worse. If they get a myocardial infarction at thirty-eight, they just had the disease worse. Many people in my group of seven hundred had premature grey hair! The average age of the group of 700 patients was about forty-two, as I mentioned.

    I sold my clinics two years ago after I was hassled by the State of Washington Department of Health since seven out of 7000 patients died over a three-year period. They died of complications connected with the infectious/autoimmune disease, not from any adverse treatment I had given. I had attracted a very ill patient group and had 7000 patients enrolled in my three clinics so the number was not so high from a statistical analysis. Since I was 65, I decided to sell my clinics and further my research from an academic approach. I learned, from experience, how academically weak bureaucratic physicians are and how they and other bureaucrats can use official connivance, modern rhetoric in the form of press releases and television announcements, and litigious muscle to further their ill-conceived goals.

    Thereafter, I traveled to nine countries and visited clinics and hospitals and took medical histories on patients I met and examined them to some degree. I have continued to do academic research on what has become an abiding interest. I have completed a book of 180 pages, or so, and it is now being edited. I will publish it unless I make a connection with a pharmaceutical company or research institution that is interested in having me join them and investigate this disease further. If I do make a connection, I will wait to publish my book until a mutually appropriate time.

    The human and other vertebrates have evolved with the microorganism in question, for millions of years. Vertebrate hosts have genetically evolved to counter the microorganism’s antigenic aggression with an antibody response, but unfortunately for us and other vertebrates, the immunological response is an autoimmunological response and we humans and other vertebrates develop chronic autoimmune disease. We have learned, genetically, to counter the autoimmune disease reasonably successfully, however, and we, and members of our species, usually reproduce and maintain our populations, and the microorganism does the same. We have developed a semi-symbiotic relationship.

    In history, there have been many epidemics and pandemics and I believe that during those times when environmental factors favored the microorganism, the infections caused acute and highly chronic inflammatory autoimmune disease (there are many autoantigens within the microorganism’s structure) that led to the development of some of those pandemics. The Athenian Plague, 430 BC, the Black Plague of the 1300’s and the Influenza of 1918 are examples, I believe. All the above great pandemics took place concomitantly with large military operations, the Peloponnesian War, The Thirty Years War, and of course WW I. The Thirty Years War took place at the time of the “mini-ice age in Europe” and the coolness and poor food supply probably was another adverse factor. There is very little sure knowledge concerning the identification of the pathogens that caused the above pandemics. Influenza, means “from the heavens” in Italian, for instance, and it has only of late become to be known as a disease caused by a virus, but again, that is not a sure thing in many cases, historically, since the electron microscope, which is needed to see viruses, was not invented until 1938.

    I hypothesize that the microorganism of which I am speaking is the cause of those great medical disasters. The recent increase of fibromyalgia, autism, ADHD, PTSD, TB, MRSA, AIDs, MS, diabetes and cancer etc. are indicators that the autoimmune disease in question is “gaining ground” on the ability of humans to immunologically protect themselves in this temporal cycle. It is a good possibility! The microorganism is ubiquitous to all vertebrate society, so it is a bilateral zooinosis, so to speak, and there is a constant reservoir of organisms in vertebrate life around the world.

    Various environmental conditions make the often-subtle infections more common. Living in economically poor societies, existing in crowded conditions, living in more soiled environments, and existing in cooler, damper environments all cause the disease to be more common. Within the military environment, especially overseas, two of the three factors, mentioned above, are prominent: living in crowded environments and living in economically poor societies. I am quite sure that the Vietnam Syndrome and the Iraq War Syndrome are manifestations of the underlying infectious and autoimmune disease of which I am writing.

    It is common for those with the rheumatoid diseases, cancer and arteriosclerosis (and aneurysms) to have neuropathies. It is common for patients with AIDS to have neuropathies, rheumatoid diseases, cancer, psychological abnormalities including homosexuality, and other infections, as you know. Typical texts like “Harrison’s Principles of Internal Medicine” mentions the associated problems, mentioned above, in AIDS patients, but also that they have rheumatological disease paradoxically! The rheumatoid diseases are known to be paraneoplastic, especially, dermatomyositis and Wegener’s granulomatosis, but in my patients through the years, all patients that developed cancer had, at least, mild rheumatoid arthritis. Guillain-Barre’ syndrome is a paraneoplastic disease also, and it is basically a wide-spread neuropathy, something like acute MS, which it surely is. Those diseases are thought to be paraneoplastic, because the underlying inflammatory, autoimmune disease causes the syndrome in question, but also the cancer that somewhat frequently appears with them.

    The organism in question is endemic in society. It is ubiquitous in nature and I found information in Russian literature that all domestic animals have infections by and are carriers of this organism at various times in their lives. I believe all vertebrates, in general, suffer infections from and are carriers of, the microorganism in question, many times in their lives, also.

    A prime concept is: from the first infection by the microorganism in question that a person has in their life, they develop the inflammatory autoimmune disease at some level. Additional infections cause an increase in the subtle, or not so subtle, autoimmune response! I think the genetics of the microorganism is varied enough to enable the organism “morph” with certain micro-environments so as to be able to exist in different micro-anatomical niches. The previous idea is a hypothesis, but it would be easy for a microbiologist to check.

    As a side-note I will mention that I met a woman who lived on Vancouver Island, British Columbia. She developed cervical cancer during her late twenties and had the surgical treatment appropriate for that condition. Then, thereafter, she had breast cancer in her mid-forties. She had bilateral mastectomies and reconstructive surgery. While talking with her I learned that her father had been a Canadian Forces dentist. There is no place more likely to contract microbial disease, than working on people’s teeth, daily! Her son had Asperger’s syndrome, an autistic spectrum mental condition. Her father died of congestive heart failure caused by idiopathic cardiomyopathy, and a sister had neurofibromatosis, all caused, I believe, by this underlying autoimmune disease that is itself caused by the microorganism in question. The former condition, cardiomyopathy, is considered in the text, “The Autoimmune Diseases”, previously cited, to be of an autoimmune nature. The latter disease, neurofibromatosis (Von Recklinghausens’s syndrome), is a disease with which I had only one patient, but I have connections to three others, and I think this underlying, inflammatory, autoimmune disease is connected to its pathogenesis.

    I had a good friend, and about ten years ago he developed ALS and died. His mother died from MS. His wife had lumbar surgery for an alleged herniated disc that was not cured by surgery. The reality is that she had sacral plexus neuritis from the same underlying, chronic, inflammatory, autoimmune disease her husband had. My friend had certain mental characteristics connected to the autoimmune disease and, of course, he eventually presented with neurological symptoms consistent with ALS. His son had chronic seizures. These neurological syndromes, within families, again, are similar to those I noted, through the years, in my practice of medicine in Washington State.

    Washington State, by the way, has, I believe, has the eighth highest attack rate for cancer considering all the states in the USA. It is well-known that the MS attack rate is high in northern tier countries and I know it is because infections by the microorganism in question are more common in cooler, more-damp locales. MS is common in my practice area. There is a semi-rural road just north of Toledo, Wa., a town with only 690 inhabitants, and three people who live thereon have MS and they are living within a half-mile of each other. Two other people who developed MS grew up close by! There has to be a logical reason! The reason is, no doubt, that they all went to the same schools and the microorganism in question was spread amongst the children as they attended school!

    I mentioned infectious diseases like AIDS, MRSA and TB, because they are not usually highly contagious, but with a relatively high-grade inflammatory, autoimmune disease the protective immune system is degraded, over time, permitting these relatively mild pathogens to become more invasive and pathological. There are other bacterial, viral, parasitic and fungal pathogens, which can cause infections in those who are immunologically depressed. For instance, perhaps malaria, leprosy, sleeping sickness and many viral diseases are members of the same subset. In areas such as Sub-Sahara Africa, a locale in which the population experiences the subject infectious disease and autoimmune response at a high frequency, it is likely that the population, as a whole, probably has a severe impairment with their immune response so that they easily contract the diseases, mentioned.

    Also, even though those with AIDS have immune deficiency due to the pathological action of the AIDS virus itself, the patients probably had immunological deficiency from the autoimmune disease in question and it permitted the AIDS virus to invade initially. It may be that some subspecies of Staphylococcus aureus are highly resistant to antibiotics, including methacillin, since it has had the opportunity to evolve genes contributing to antibiotic resistance in those humans, who have had immune system degradation previously by the autoimmune disease in question. This is another hypothesis within my theory, but I have reasons for it, since many of my patients developed unusual, aggressive infections especially if they had the autoimmune disease seriously.

    Another area of medicine and human behavior I have touched on, above, is the common development of psychological disease states and these are usually described as autism, ADHD, PTSD, schizophrenia, depression, manic-depressive illness, chronic anxiety, explosive personality, the driven, Type A personality, Alzheimer’s disease, and Parkinson’s disease (the last two are probable). Other, more subtle psychological and personality abnormalities are also caused by this underlying autoimmune disease process, such as learning deficits. In addition, chronic fatigue syndrome and perhaps anorexia nervosa are caused by this disease process. All the above conditions exist as central nervous system neuropathies, that is, central nervous manifestations of a systemic autoimmune, inflammatory disease process. The inflammatory autoimmune disease disturbs the blood-brain barrier enabling autoimmune factors and other serum factors to enter the brain tissues and cause neurological tissue damage. The time in life, the severity, the chronicity, the subtypes of microorganism, the frequency of the infection, all which affect the autoimmune response, and the ability of a given person immune system to combat the infectious disease and autoimmune response, causes the variation in clinical psychological manifestations noted in the above conditions.

    To understand the systemic autoimmune inflammatory disease process, one has to mentally exit from the a priori thought picture, that we, physicians, medical scientists and lay-persons, have been conditioned to think about disease development. For sixty years, at least, we have been educated to think according to the “specialist divisions of medicine”. The human body is not naturally segregated, conveniently, into systems except as a tool to understand anatomy in medical training as one is learning that subject. One must think as the body reacts: in a systemic fashion. A person must realize that there is an infectious disease, which can be acute and important or so mild and chronic that the patient may feel normal, but both cause an inflammatory, autoimmune attack, usually subtle, but which can be acute and severe. Even the carrier state stimulates an immune and therefore an autoimmune response. One has to realize that the autoimmune attack ebbs and flows over time within the individual depending on the microbial environment in which one lives and depending on the individual immune response to the infectious process and the autoimmune process.

    One has to realize that each tissue and therefore organ will respond to the pathological, inflammatory, autoimmune attack differently. The heart develops arteriosclerosis, cardiac arrhythmias, cardiomyopathy and pericarditis; the skin develops rosacea, erythroderma, spider nevi, nevi, seborrheic keratosis (age marks) and dermatitis and graying of the hair. The gastrointestinal system organs develop esophagitis, ulcers, polyps, diverticula, primary sclerosing cholangitis, ulcerative colitis, Crohn’s disease, autoimmune hepatitis , cholecystitis, and pancreatitis. The brain develops functional abnormalities such as autism, ADHD, PTSD, schizophrenia, disassociative phenomenon, manic-depression, depression, learning deficits, personality disorders, Alzheimer’s disease and Parkinson’s disease. Many humans are in jails and prisons because of the behavioral abnormalities they develop from autoimmune cerebritis. Patients can develop learning deficits and one of the losses can be moral learning. The subtle mental change that takes place during puberty can be altered and some individuals experience a decreased transition to the heterosexual orientation and stay non-differentiated in that respect, but they develop normal somatic secondary sexual characteristics, thus the homosexual individual is developed. A combination of the explosive personality, deviant sexual orientation, and immoral thinking patterns produce, I think, the criminal personality. We are conditioned to think that people are just bad, but I think they suffer from an organic, inflammatory, autoimmune cerebritis, which causes their abnormal behavioral tendencies.

    The brain malfunctions in various ways depending on the pattern of infectious disease and therefore the autoimmune response, and how the autoimmune attack has developed. Most children with autism are treated by pediatricians or pediatric neurologists. Patients who have Parkinson’s disease are seen by neurologists, internists, or psychiatrists, so the similarities are not noticed in the current specialty, clinical arrangement. If you think about it, a child with high-grade autism acts like a miniature individual with high-grade Parkinson’s disease. I have had both types of patients in my clinic and I was surprised how familiar they were. The child with autism had developmental hemophilia due to the autoimmune disease in question also. The child’s mother had lupus erythematosis and fibromyalgia with sciatic neuritis and brachial plexus neuritis, all of an autoimmune cause. The child’s mother was, no doubt, the “microbial carrier” that led to her child developing autoimmune disease manifested by severe autism (autoimmune cerebritis) at about thee years old.

    The vascular tree develops arteriosclerosis, aneurysms, phlebitis, thrombophlebitis, thromboembolism and lymphedema. The autoimmune attack on the gonads disturbs meiosis and causes genetic changes that lead to genetic birth defects. A similar inflammatory autoimmune attack on somatic cells causes somatic genetic aberrations, which can lead to clinical cancer development. Autoantibodies can pass through the placenta and cause a great variety of developmental birth defects. One has to realize that phenomenon that appear in complex systems appear in a somewhat random fashion!

    Those with autoimmune inflammatory disease experience difficulty healing. The slow- union or non-union of fractures, the slow healing of surgical sites with the development of keloids, incisional hernias, and adhesions are common in such a group. At times women, if they experience a high-grade autoimmune condition, can pass autoantibodies through the placenta and cause difficulty in embryological tissue-plane-merging and so cleft palate and spina bifida, among other developmental birth defects, can develop. This infectious disease and the autoimmunological response is much more common in “third world countries” such as Vietnam, and of course there are many missions to that country to repair cleft palate and developmental abnormalities to the heart, for instance.

    Patients and clinicians notice abnormalities in the organs of special senses most commonly. The eyes develop cataracts, presbyopia, macular degeneration, glaucoma, retinal detachment, iritis, uveitis, penguecula development, diplopia, scleritis and choroiditis, etc. The hearing sense develops tinnitis, and decreased function. The vestibular nerve can malfunction and the individual may develop vertigo. The facial nerve abnormalities lead to Bell’s palsey. Autoimmune trigeminal neuritis causes migraine headaches. Rheumatoid tempo-mandibular arthritis causes TMJ headaches and it is not unusual for both types of headaches to exist concomitantly since they are both caused by the same underlying autoimmune vasculitic condition.

    Most people have heard about the risk factors of coronary artery disease: a positive family history of CAD, type A personality, high cholesterol, diabetes, hypertension, transverse ear lobe folds (an idea of about 15 years ago), and I will ad my own: neurological back pain: sciatica. The same risk factors fit for those with arteriolar aneurysms and peripheral vascular disease. The reality is that all the markers or risk factors are simply concomitant phenomena caused by the inflammatory, autoimmune disease about which I am writing. The positive family history is not due to genetics, it is because individuals within families are more likely to contract the infection in question, and therefore develop the autoimmune disease, more frequently.

    I have been to Vietnam, Taiwan, and Mexico recently for extended periods and I know the underlying infectious disease and the autoimmune response is more severe and endemic in those more economically undeveloped locales than here, in America, and in Western Europe. The microorganism has been brought here, including various strains that are more pathological, and such importation has caused an increase in the commonality and severity of the autoimmune disease process, that is systemic in nature, and therefore the above conditions are more prevalent than, let us say, 30 years ago. There are other influences that have caused the infection and autoimmune response to be more prevalent, also.

    Being a general practitioner, and having worked in the U.S. Navy in the USA and overseas, or in small-town clinics all my professional life, so I have not published in academic journals. I did, however speak at the Second World Conference on Immune-Mediated Diseases in Moscow, last September. I was a substitute speaker, for I took the place of a Russian scientist who had had a heart attack, on an afternoon of one of the last days. I think most of the “listeners” were Russian pediatric allergists, since they sponsored the meeting. Most of the international “academics” had left since they were there, basically, to give their own talks. I am not sure if many of the Russians understood my “rapid English” since I only had twenty-five minutes to speak. Since this is a systemic disease process, it is naturally complex. For that reason I have written a book so that I can explain many more of the mechanisms of disease production in the various tissues and organs and how the underlying, systemic, inflammatory autoimmune disease plays the key role.

    Most medical and scientific research, nowadays, is conducted via microscopic or submicroscopic means. The articles in the 2000, or so, medical journals printed in the world can attest to that fact. Most research findings do not really affect the practical advancement of medical science wherein the treatment of diseases is improved. My research was of a macroscopic, clinical and epidemiological nature. I used induction to reason out and see the relationships between the biological and clinical observations I have made being a physician. I have seen 230,000 patient interfaces and that comprises a great number of observations. I had a great setting, being an independent clinic owner, in a poor area, for nearly a quarter century. Poor people are sicker people, in general, and being a general practitioner, and treating all diseases, I “had a chance” to put the puzzle together.

    Another advantage I had, perhaps, is that I am a former U.S. Marine officer. I was a Phantom II pilot with 146 combat missions in the Vietnam War. While flying a high performance jet, I had to learn to integrate a great number of factors, simultaneously, and perhaps I became something of a systems analyst, at 500kts with people shooting at me! Marines have a saying, “the difficult we do immediately, and the impossible just takes a little longer.” Humorous, it is, but Tarawa, Iwo Jima, and other nasty places were dealt with successfully through perseverance more than intelligence. My investigation took a great amount of perseverance, an experienced knowledge of many disease entities, being located in one clinic for a long period, and I saw, medically, males and females of all ages and for all diseases. I had the perseverance and the sense of duty to my patients to work 12-14 hours a day for two and one-half years and eventually I “figured out” the puzzle, the enigma!

    The next step in providing proper assurance that my theory is correct, is that I would need to connect with an investigative group that has a connection to a large hospital/clinic system and coordinate serology and inflammatory marker testing of cohorts of patients. Patients with: breast cancer, colon cancer, brain cancer, leukemia, diabetes, Cushing’s syndrome, Addison’s disease, Polycystic ovary disease, Parkinson’s disease, Alzheimer’s disease, arteriosclerosis, stroke, hypothyroidism, ulcerative colitis, chronic pain from fibromyalgia and neuropathies, esophagitis, ulcers, AIDS, TB, MRSA, the rheumatic diseases, Crohn’s disease, gastric ulcers, etc.

    Perhaps fifty of each type of patient could be enrolled in the serological study. Phlebotomies could be organized through the hospital and clinic via a contractual agreement and each patient or caretaker could sign a permission slip for the test. Such testing is quite simple to organize, I think. If the serology results are positive, like they were in my own clinic, that is, if something like 60% of patients have elevated serology, the theory is proven. Antibody levels drop, over time, if a patient does not have an infection in the intervening period, but the immune system is still operating in a pathological way, even if the antibodies, that are also autoantibodies, are at a lower level. The patient is still immunologically primed to respond aggressively to repeated infection in the future. This is what causes exacerbations of rheumatoid arthritis, for instance, and why back pain exacerbates: because the autoimmune disease improves, to some degree, if a person does not have an infection, by the organism in question, for a certain period, and then if a new infection takes place the inflammatory autoimmune disease will become worse.

    A person could elect to do further testing on a greater number and on more varied cohorts of patients, in addition, to make the proof more firm. Once the theory is proven, the research can start in an effort to make autoantigen, autoantibody and target-tissue blocking agents. The first and last are probably similar. A group of medications from the existing pharmacopeia can be developed to inhibit the autoimmune response. I had many, many patients on a selection of medications that helped without question. A vaccine can be developed!

    Many people die early in life from cancer, heart disease, and aneurysm formation, because they, more or less, age early. The individual organs that develop clinical abnormalities from the underlying, inflammatory, autoimmune disease exhibit them with some randomness, which would be natural in a complex system. It is quite common, however, for a person to have low back pain, an explosive or driven personality (Type A), some arthritis in the knee, and experience an arthroscopic surgical procedure. Then later, arthritis in the hands may appear and then age marks (seborrheic keratosis) develop. The individual might have had nevi and need to watch for malignant melanoma. After a few years they have a myocardial infarction or angina and have a stent emplaced. Perhaps later, they develop atrial fibrillation, and then ten years later they get cancer. The temporal appearance of the diseases mentioned above, which are really target –organ manifestations of an underlying autoimmune disease, and are in the sequence I noted in the members of families in my area, among others. One phenomenon that takes place, that we just take for granted, is that as we age we get ruddy faces and graying of the hair. Both are manifestations of the subtle, autoimmune, inflammatory disease that we all have! The universal physical changes that all humans experience, commonly termed aging, are, for sure, for the most part, the physical manifestations of this underlying infectious/autoimmune, inflammatory process.

    Like all break-throughs in science, I was the receiver of millions of bits of knowledge from my mentors through the years and then from my own clinical experiences. All the bits of “passed-on” knowledge ( I sound like Bill Gates=bits of knowledge) and personal medical observations led to a generalization. Like many new insights it is simple once it is understood, like: E=MC sq. Even the visualization of the disease mentally, is somewhat akin to Einstein’s heuristic thoughts that led to the theory of special relativity.

    Einstein wrote, the simpler a theory, and the more observations it explains, the more likely it is to be correct (paraphrased). My theory is simple and it explains most of the puzzling observations I have had in medicine for over thirty years, and serological testing and the taking of medical histories proved it is correct.

    James W. Goding, MD, Ph.D., Monash University, Australia, wrote in the epilogue of “The Autoimmune Diseases”, “Would the Real Autoantigen Please Stand Up!” He was referring to the concept that there was probably one autoantigen or group of antigens from one source that caused the autoimmune diseases listed in that long text. I have found it, I am very sure.

    I know that many would think that I, being an sixty-eight year old osteopathic, general practitioner, may be one of the most unlikely medical professionals to develop a major insight in medicine! I was, however, the one independently seeing patients of both sexes, of all ages, for all diseases, in one community, for a long period, an unusual situation in medicine nowadays in the period of procedural, specialty-dominated medicine. In my setting, I alone had the responsibility to determine what was medically causing disease processes within my patients. I was an independent physician and worked in an economically poor area. I had the independence of thought, to determine what I have managed.

    Also, one must realize that John Snow, a general physician in London, did an epidemiological study and determined that cholera was spread by water supplies before the microbiological theory was well developed. In addition, one must remember that Louis Pasteur and Claude Bernard were not connected to a research institute. One could consider that Walter Reed and his physician associates, Dr.Jesse Lazear and Dr. James Carroll, and even Dr. Carlos Findlay, the Cuban physician who advanced the theory that the mosquito transmitted yellow fever twenty years before Dr. Reed’s research project, who together proved that Yellow Fever was spread via the mosquito, were simply general practice physicians. To tell you the truth, the division of medicine into specialties has harmed the discovery of disease processes because specialists, by concept and training, develop a constricted view of medical science and t times never see sick patients. Since this autoimmune disease presents primarily as a vasculitis, and since there are no vasculogists (a new word), no one would ever determine that people have a wide-spread, inflammatory, autoimmune, vasculitic disease!

    To give you a better idea of how simple it is, just look in “Harrison’s Principles of Internal Medicine, 16th Edition”, within the section that discusses rheumatoid arthritis. The information provided indicates that there is no known cause for rheumatoid arthritis (RA), and that it is a systemic, autoimmune disease that features arthritis, neuropathy, and vasculitis, and that it can cause organ infarction, even a myocardial infarction. Earlier editions (the 13th edition, for instance) also indicated that a feverish disease could cause an exacerbation of RA. Since myocardial infarctions are caused by arteriosclerosis, as a general disease process, other clinical manifestations are peripheral vascular disease, stroke, arterial aneurysms and venous abnormalities such as venous thrombosis. I just had to learn what caused the feverish disease that triggered exacerbations of RA, and put the puzzle together. Thereafter, I just had to add on the fact that most people who develop cancer have, at least, one of the rheumatological diseases, for instance rheumatoid arthritis, at least subtlety, and so there is no doubt that the rheumatoid diseases and cancer are caused by the same underlying autoimmune disease process.

    Even Galen, the famous Greek physician, scientist and philosopher, in 200 AD, coined the word “rheumatism” because the word-root rheum means phlegm. He knew that respiratory infections that frequently caused expectoration (coughing up phlegm) and coryza (phlegm from the nose), led to a miserable, chronic condition in his patients. He termed it “rheumatismos” or in English, “rheumatism”. Yes, arteriosclerosis, cancer, the endocrine diseases, the rheumatoid diseases, peripheral and central neuropathies and many more conditions are part of the rheumatism concept. They are all end-organ manifestations of the systemic, autoimmune, inflammatory disease of rheumatism!

    Philology, the science of language, has, over hundreds of years, incorporated a great amount of wisdom within itself . In the Webster’s New Twentieth Century Dictionary, 1976, it mentions under the word rheumatism: “any of various painful conditions of the joints and muscles; especial y, a disease believed to be caused by a microorganism and characterized by inflammation and pain in the joints.”

    The “nut” of my theory has been known for thousands of years, but now with added, more recent knowledge from bacteriology, immunology, and the autoimmune concept, and by thinking systemically, as I saw my patients, especially during the clinical, epidemiological investigation I have mentioned, the nature of the disease process let itself be known.

    I have presented the case for a disease that is so common, since it is caused by a microorganism ubiquitous to the society of vertebrates, and the autoimmune, inflammatory affects so universal, that we all have it. You, me, my kids, my ex-wife, my neighbors (I know the family: Dad has Charcot-Marie-Toothe syndrome (high arches and neuropathy of the legs), a cardiac stent and then a CABG and between the two was in the hospital for 8 days for “pneumonia with complications”, which was really a disease episode from the organism in question. Both his sons have the disease quite meaningfully as they have chronic pain and peripheral neuropathies. All of us humans in the world have the disease, because the organism is so ubiquitous. Some people and families have it worse, naturally. Those individuals and families often do not function well in life.

    Since I have finished a book of approximately 200 pages concerning this disease process I could naturally write on and on. I will not, however, but I will say this: Over the last fifteen years there has been a great increase in the number of cancer, fibromyalgia, chronic pain, and autistic patients and the appearance of many infections such as TB, syphlis, MRSA, etc., in the American scene, of which I am most familiar. There has also been special manifestations of diseases, psychological and physical, in military men returning from overseas duty, especially from Vietnam and the Middle East. The reason this is true, I believe, is that the pathogens that cause the diseases are more common in poor societies and we, by our war activities, make the disease more manifest in the civilians in the war zone and within our own troops. In addition, infections by the microorganism and therefore the autoimmune response has become more meaningful in American society due to the immigration of ten million people from Mexico and Southeast Asia. Frequent international air travel has introduced microorganisms, or more pathological strains of microorganisms, into our country also.

    Hopefully, you have found this letter a little entertaining and interesting. I think I am correct concerning the principles of my theory. I have interviewed, medically, over two hundred and thirty thousand patients during 30 year practice period. I was a physician in medicine, with a wide interest and the responsibility for treating my patients with all medical problems. I practiced in an economically poor area, with quite a few Mexican immigrants, so the markers of disease appeared more overtly than in a more affluent community. I have proved my theory via serological testing. I spent nine months visiting nine countries to determine that this disease process is world-wide. I am presenting a new generalization in medicine, a unifying theory of most or many of the idiopathic disease entities that have filled medical books for decades. The guiding theory, and the pathological and immunological principles that support it, will enable medical scientists to “focus” on the cause of diseases (really target-organ manifestations of an underlying autoimmune disease) and not just try this or that random molecule via a clinical trial, to see if it works on this or that malady.

    I have had trouble relaying my information to a research organization because I am semi-retired, sixty-eight, an osteopathic general practitioner, and not an allopathic physician, because I have never worked in a research organization and I have not had any research published. Really, I have found that most individuals, who are in investigative organizations, are typically comfortable dealing with professionals similar to themselves and are not overtly open to new ideas from a person not currently in the structured research industry. Naturally, I can understand such reluctance. The reality is, however, millions of researchers world-wide are usually working with a similar mental-set, using similar techniques and intellectual approaches, and the results of research leaves something to be desired since there have been no “major” breakthroughs detailing the cause of a major diseases in decades!

    I am interested in collaborating with a research organization that can help further prove my theory and develop the pharmaceuticals needed to control the disease process. I think that the pharmaceuticals will surely be the most helpful to members of human society, and therefore the most profitable, in the history of medical treatment!

    I have been a solo practitioner in a small town most of my medical career and have not associated with other physicians much. I have, however, an old professional and personal friend, Albert Mark, who I have known since I was 16, since I worked for him when he was an active pharmacist. His phone is 1-425-454-0300. His e-mail is: AMMark914@gmail.com. You are free to talk to him concerning me, my background, and my ethics. In addition, I still communicate with my anatomy professor from medical school, Jack Julyan, PhD. His e-mail is carol@julyan.org. He knew me quite well and he was a great teacher.
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    Thanks for reading this letter. If you have any interest, please contact me at: ecnal-c@hotmail.com, or 360-864-4371. My address is PMB 227; 120 State Ave. N.E., Olympia, Wa., 98501

    Yours Truly,

    Lance W. Christiansen, DO

    Yours,

    Lance Christiansen, DO.

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