La comercialización de la biotecnología en China

Estimado Dr. Gingras,

He sido médico durante un largo período. He llevado a cabo una investigación y han aprendido la causa de muchas enfermedades idiopáticas como las neuropatías periféricas, neuropatías centrales, la arteriosclerosis, el cáncer, y otros. Me doy cuenta de mi reclamo suena pomposo, pero como la mayoría de las cosas, es muy sencillo una vez que los principios se "descubrió".

Estoy buscando un "lugar para demostrar aún más mi teoría", y luego desarrollar y fabricar los agentes de autoanticuerpos bloqueadores para controlar la enfermedad de base autoinmune que provoca las manifestaciones en órganos blanco, por lo general piensa que las enfermedades.

Yo he determinado el tipo de microorganismo que provoca el proceso de la enfermedad, esencialmente.

Si usted tiene interés en conocer más en contacto conmigo en mi correo electrónico del sitio.

He estado en la Infantería de Marina, en Vietnam como piloto y también trabajó en Japón durante un año. He estado en Taiwán, pero no la China continental. Me gustaría trabajar allí, sin embargo.

Yo tenía tres clínicas de una sola vez, pero ahora estoy semi-retirado y hacer la investigación académica para reforzar la investigación clínica que hice durante un período de tres años. Voy a adjuntar un documento, si puedo.

Una teoría unificadora de las Enfermedades,

Manifestaciones autoinmunes, enfermedades y órgano blanco-

Soy un médico de medicina general en la medicina, y tengo, estoy seguro, ha desarrollado un conocimiento significativo sobre la causa de muchas enfermedades, hasta ahora, idiopáticas. Enfermedades idiopáticas se han descrito con mayor frecuencia durante los últimos sesenta años después de que la mayoría de las enfermedades infecciosas se entiende y se controla con antibióticos en el primer semestre del 1900. Ahora, los textos médicos se han llenado con las descripciones de miles de enfermedades idiopáticas, las enfermedades con una causa conocida, y puesto que sus causas no se conocen los tratamientos para la enfermedad son la alteración no se cura la enfermedad.

Sorprendentemente, la mayoría de las enfermedades idiopáticas son de órgano blanco manifestación de una visión sistémica, inflamatoria, autoinmune-enfermedad. La enfermedad autoinmune es causada por una condición inflamatoria, autoinmune, lo que se está causada o provocada por una infección por un microorganismo. Se trata de un microorganismo que es bastante común y es ubicuo a las poblaciones de vertebrados, lo que incluye los animales domésticos y seres humanos. Con esto en mente, una persona puede considerar la enfermedad de un zooinosis bilateral.

Algunas manifestaciones de órganos diana de la enfermedad autoinmune se observa comúnmente dermatológicamente. Observadores médicos no suelen pensar que las características dermatológicas como nevos, adelgazamiento de la piel y la formación de arrugas, queratosis seborreica, los angiomas, la dermatitis seborreica, el eccema, poliosis, encanecimiento del cabello, etc son necesariamente de naturaleza patológica. A menudo se cree que son una parte del proceso de envejecimiento. Sin embargo, si una persona desarrolla la enfermedad de las arterias coronarias, cáncer, glaucoma, cálculos biliares, una enfermedad reumatoide o la diabetes, a medida que envejecen, y el problema puede estar localizado en un órgano determinado por un especialista capacitado procesalmente, se piensa que es un específica de la enfermedad en la que es en realidad una manifestación de órgano blanco del proceso sistémico, enfermedad autoinmune mediada.

Yo, a trabajar como médico general, determinó que la mayoría de las enfermedades idiopáticas son órganos blanco manifestaciones de un proceso sistémico, enfermedad inflamatoria autoinmune. Al tener un fondo diferente educativa (parte de ella en la aviación el análisis de sistemas) y enfoque clínico de la medicina, y por el tratamiento de hombres y mujeres, de todas las edades, para todas las enfermedades, yo era capaz de tener ideas que dieron lugar a una nueva filosofía de la enfermedad desarrollo, que explica la causa de la mayoría de las enfermedades idiopáticas incluyendo muchas enfermedades dermatológicas, enfermedades gastrointestinales, enfermedades neurológicas, cáncer, arteriosclerosis, las enfermedades reumáticas y las enfermedades endocrinas, que en conjunto, pueden ser concebidas como una gran parte del proceso de envejecimiento .

Vi a más de 230.000 visitas de pacientes, incluyendo 1.000 visitas a domicilio, en una comunidad pobre, el registro de semi-rural con una industria moderna. Durante un largo período de tiempo que tomó nota de que ciertas combinaciones de enfermedades en los miembros de las familias de hasta cuatro generaciones. Debido a ese fenómeno, y debido a la frecuencia de la esclerosis múltiple y neuropatías periféricas en mi comunidad, me decidí a hacer una investigación clínica y epidemiológica. La información contenida en las páginas siguientes se explica mi búsqueda, algunos de mis hallazgos, y algunas cosas que son apropiadas en el futuro. No he mencionado la identificación del microorganismo que desencadena la respuesta autoinmune ya que la información es de mi conocimiento de su propiedad en este momento. Gracias por leer esta larga carta / documento, por adelantado.

He sido médico militar y civil de treinta y un años, un teórico clínica médica en los últimos tres años de mi periodo de prácticas, y un investigador académico de los últimos tres años.

Algunas ciencias han experimentado avances cuánticos en el pasado, por ejemplo, la física (nunca mejor dicho), la química física, la astronomía y la cosmología, la ciencia del láser, la inmunología y tal vez incluso las ideas que llevaron a que el transistor digital y los conceptos de código de computadora, que a partir de entonces llevó a la "revolución informática". Medicina, como un esfuerzo científico, ha experimentado muchos avances históricamente, pero ninguno de carácter teórico que describe las causas de las enfermedades desde finales de 1700 o tal vez la de principios de 1800, cuando la hipótesis y la teoría desarrollada que los microorganismos pueden causar enfermedades. Este descubrimiento llevó a la idea, lo que resultó en el desarrollo de los antibióticos en la década de 1930 y 1940. Ese descubrimiento fue probablemente el último gran avance en la medicina!

Como ustedes saben, los esfuerzos de diagnóstico y tratamiento se han desarrollado durante los últimos sesenta años, con préstamos de otros campos de alta tecnología como la electrónica, la ciencia láser, el ultrasonido, la bioquímica y la ingeniería informática, pero no de puntos de vista determinados directamente de la medicina teórica, que podría proporcionar un enfoque directo a la naturaleza del desarrollo de la enfermedad y por lo tanto su tratamiento. Hay muchos dispositivos de alta tecnología para ayudar a minimizar los efectos de la enfermedad en un determinado órgano o para ayudar a hacer un diagnóstico más definitivo, pero una vez más, los efectos de las enfermedades han sido alteradas y que no están siendo científicamente abordado por primera determinación de sus causas .

El desarrollo de la ciencia de la genética, células madre, conceptos y otros nuevos conceptos de la biología, dio lugar a la idea de que el uso de tales descubrimientos significativos y complejos a menudo conducen a un nuevo tratamiento para "enfermedad de tal o cual" incluso si la causa de la enfermedad no se conoce. No siempre parece ser una nueva "causa célebre" en la medicina.

Durante los últimos tres años de mi práctica periodo, llevé a cabo una investigación epidemiológica, clínica y, posteriormente, me han llevado a cabo un proyecto de dos años epidemiológica, académico e histórico la investigación médica, los datos de los que, mayoritariamente apoya mi teoría. Durante un período de nueve meses viajé a nueve países y visitó las clínicas y hospitales y habló con y examinó gente que conocí en los varios lugares. Yo me he asegurado de que la infección microbiana y la enfermedad autoinmune que provoca, lo que hace que muchos tipos de manifestaciones de órgano final, incluyendo el cáncer, la arteriosclerosis, defectos de nacimiento, y las enfermedades reumatoides, por ejemplo, es uno que existe en todo el mundo, como lo había teorizado, pero por supuesto que es más grave en ciertos lugares del mundo que en otras.

Parte de mis procesos de pensamiento implicados ideas que se produjeron durante la larga historia de la medicina y cómo los conceptos médicos de la formación de la enfermedad y los tratamientos para ellos han evolucionado a través del tiempo. Como usted bien sabe, las enfermedades infecciosas causado grandes problemas para la salud de la humanidad por siglos incontables, pero la aparición de la microbiología y el descubrimiento de las técnicas de higiene y los antibióticos, en la década de mediados de 1800 hasta mediados de 1900, la disminución de la frecuencia e importancia de las enfermedades infecciosas . Antes de que el período mencionado, incluso las enfermedades causadas por microorganismos eran de naturaleza idiopática.

Desde la década de 1930, cuando los antibióticos se utilizan clínicamente por primera vez, los textos médicos que "llegan a ser dominadas" por las descripciones de las condiciones que son enfermedades muy idiopática: cáncer, neuropatías periféricas, la arteriosclerosis, las enfermedades reumáticas diferentes, las enfermedades endocrinas, osteoporosis, enfermedad de Alzheimer, la enfermedad de Parkinson, el autismo, el TDAH, trastorno de estrés postraumático, la fibromialgia y las enfermedades de muchos más de este tipo. Estos, y probablemente 2000 enfermedades idiopáticas adicionales, se clasifican dentro de los textos médicos, tales como "de Harrison Principios de Medicina Interna" y que se idiopática, no hay causa conocida para cualquiera de ellos. Si las causas de enfermedades no son conocidos, los tratamientos son la enfermedad de alterar, no curado la enfermedad, la mayor parte del tiempo. Como un ejemplo de esta situación, es común para eliminar la vejiga de una persona biliar debido a la inflamación, pero los cirujanos raramente preguntar por qué la vesícula biliar se inflama en el primer lugar! Los pacientes con esclerosis múltiple tienen marcadores de inflamación, y los depósitos calcificados en el sistema nervioso central, pero los neurólogos raramente practican seriamente tratar de determinar la causa de la EM. Los pacientes que tienen cáncer a menudo tienen dolor neurológico, pero nadie sabe por qué tienen tanto dolor. Los pacientes con SIDA con frecuencia recibe las enfermedades reumáticas, las neuropatías, las infecciones y el cáncer, pero poco se sabe por qué todos ellos existen en este subgrupo de pacientes.

Que han determinado la causa, una causa sistémica subyacente, para la mayoría de las enfermedades idiopáticas, y me han proporcionado una descripción de mi descubrimiento, a continuación. Se podría decir que he descubierto una teoría unificadora de las enfermedades idiopáticas, ya que sería estadísticamente inusual, y quizás imposible, para que haya causas para el 2000 2000, o más, las enfermedades que llenan los textos médicos y con el que los médicos e investigadores médicos tratar, y están desconcertados por todos los días.

I have been a general practice physician, both in the US Navy and in civilian life for nearly thirty years, but over the last six years, the best description of my activities is that I have worked as a theoretical, medical investigator. I was a jet pilot in the US Marine Corps, surprisingly, during my late twenties and early thirties, and then, since I originally had a degree in biology from Whitman College, I re-educated myself, by taking pre-medicine studies at the University of Washington and medical school at the Chicago College of Osteopathic Medicine, into a medical career. I practiced medicine in the Navy as a general medical officer/flight surgeon for five years during active duty and for five years as a reservist. For twenty-three years, thereafter, I was a small-town general practitioner. I always worked mentally in an effort to determine the causes of diseases, since I thought part of my duty as physician was to be a physician-investigator, as well as a being a diagnostician and treating physician.

I practiced in a semi-rural area of southwest Washington for over twenty years. I was a minor entrepreneur in medicine, for I developed three clinics and had three physician assistants helping me, but I personally saw most of the serious disease cases. I had a total enrollment of 7000 patients in my clinics, so I had a great volume of cases. I prided myself, after I had a number of years of experience, in treating all kinds of medical problems, for both males and females, of all ages, and not acting as a conveyor and send patients with meaningful diseases to specialists. Naturally, I referred patients to specialists for major surgery, internal scoping, imaging procedures, and ICU hospitalization since I practiced too far from a hospital to have such a practice. Such an experience in medicine is not common nowadays, since for fifty or more years medicine has been fragmented into artificial procedural, age-defined, organ oriented, system-related, disease related, and politically determined (family practice) specialties.

After seeing patients about twenty-five years I became somewhat introspective and realized that unless a patient had had a sprain, a laceration, or a fracture, or unless they had had an infection, nearly all the rest of the medical problems patients experienced were idiopathic (their causes are not known!). I realized that most treatments for idiopathic conditions had been developed by trial and error methods through the ages and the modern version of those efforts are the “clinical trials” of which you are, no doubt, highly familiar. There were situations wherein treating the above conditions, lacerations, fractures, sprains, and infections, were complicated. Slow healing of lacerations or surgical sites with the formation of incisional hernias, keloid development (large scars) and internal adhesions was common. The non-union or delayed-union of fractures, and sprains that caused chronic pain and swelling for months and sometimes years occurred somewhat frequently. At times, another “idiopathic disease name” was applied to explain patient's chronic pain: reflex sympathetic dystrophy or complex regional pain syndrome. No sure explanation for the cause of these syndromes had ever been given, accurately, in medical texts. Also, some infections are very difficult to treat even with existing antibiotics. There seemed to be something occult going on.

I worked in a logging and millwork area. I practiced in the small town of Toledo, Washington after I was a Navy physician, because the owner, who had had cardiac by-pass surgery wanted to retire and he “sold-out” to me for nothing down. I wanted to be a little isolated from “specialty medicine” because I did not want be, simply, a patient conveyor as I had been in the Navy. Well, I surely was not a conveyor and I was busy from the first day wherein I saw forty-six patients in a 12 hour shift. I worked nearly as steady for 21 years.

During the last five or six years I decided that neurological lumbar and cervical spinal pain was not, most of the time, caused by herniated spinal discs. It was rare that a patient improved, in a reasonable time, after lumbar or cervical spinal surgery! I treated many, many cases through the years. I decided to do an epidemiological, clinical investigation and try to find out the “true cause” for lumbar/buttock pain and neuropathy to the lower extremity and shoulder/neck pain and neuropathy to the upper extremity. Little did I know that I was involving myself in a many year project!

Over a two and one-half year period I attracted nearly 700 miserable, painful patients due to the severe peripheral neuropathy from which they suffered. One might consider them to be the “worst end of the bell-shaped curve”. Many of the patients, probably 40% had had spinal surgery and some patients suffered many, many surgeries. A woman patient had had four cervical surgeries and three lumbar surgeries performed by the same neurosurgeon! She was no better for her experiences. One man had had experienced eight lumbar surgeries and was not any better, either. It was common to have neurological problems in one lower and one upper extremity and at times in all four extremities. It was somewhat common for many members in a given family to have neurologically caused lower or upper back pain! It seemed that there was a systemic, somewhat contagious, occult, disease process going on, but somehow it localized in the nerves of the lumbar/buttock and the shoulder/cervical area.

During my clinical, epidemiological investigation, I used the techniques any physician could use. I did physical examinations and analytic, neurological physical examinations on my patients, but I used them intensely and repeatedly. I did personal and family medical histories intensely and repeatedly, also. I determined that the neurological problems were located deep in the buttock and shoulder, and not in the spine! I realized that pain is just one manifestation of inflammation (dolor, rubor, tumor, calor = from medicine 101), but I did not know what caused the inflammation.

I realized that these severely painful patients had similar dermatological abnormalities, and most had some kind of rheumatological malady. Rheumatoid arthritis, a history of juvenile rheumatoid arthritis, lupus erythematosis, scleraderma, Wegener's granulomatosis, Sjorgen's syndrome, mixed connective tissue disease, ankylosing spondylitis, and psoriasis, were all represented within the group. Naturally, mild rheumatoid arthritis was the most common. I realized that these diseases were all inflammatory and autoimmune in nature.

Many patients had an endocrine condition: hypothyroidism, hypoparathyroidism, Addison's disease, Cushing's syndrome, diabetes, pituitary, testicular and ovarian abnormalities were common. I realized that many of these diseases were also autoimmune in nature.

I did a search of medical literature and found the malady of autoimmune-mediated neuropathy. I realized that my patients had that problem: autoimmune-mediated, vasculitic neuropathy. The findings came from the Mayo Clinic Peripheral Nerve Group and Weill Medical College, which is a part of Cornell University.

Eventually, I learned how the autoimmune-mediated vasculitic neuropathy could be traumatically exacerbated, locally, and caused the somewhat-focused pain deep in the lumbosacral/ buttock area and the shoulder/cervical area. The pathology was not located in the lumbar or cervical spine, as I mentioned above, whereat surgical procedures are focused, but referred pain patterns made the pain radiate into those spinal areas. There are a few herniated discs I suppose, but not many. Surgery for them, however, is quite common! With a touch of sarcasm I will say that some time ago, well-meaning and reputable physicians bled patients for all kinds of problems, too.

As I kept on working on the problem, I attracted more and more patients, and eventually I realized that many patients had had or developed cancer while I was seeing them. Seventy, out of seven hundred, miserable, painful, patients who came to see me due to chronic painful neuropathies, had had or developed cancer. The average age was about 43, or so, and all types of cancers were represented, but of course, the most common kinds such as breast, cervical, skin, and colon were the most common.

Some patients had had many cases of cancer. One woman who was born in Manitoba, who I interviewed where she lived on Vancouver Island, had had four major cancers and I noted that she had a squamous cell carcinoma on her face during my first interview. She had had cervical cancer, breast cancer, colon cancer, and then another breast cancer, and squamous cell cancer, over a thirty-year period. There is no way a person could develop five cancers unless there was an underlying disease process stimulating the pathological, somatic, genetic changes. I learned that she became severely ill with an infectious disease at the hospital where she was born and was not expected to live. She was “tagged” with an autoimmune disease nearly from birth and developed the five cancers secondary to the autoimmune, inflammatory assault during her lifetime!

Another woman, who was in chronic pain for previously diagnosed fibromyalgia developed a sarcoma on her anticubital fossa (anterior side of the elbow) as I was seeing her. Another woman had developed Paget's breast cancer and chronic lymphocytic leukemia, over a three-year period. The patient with Wegener's granulomatosis developed leukemia and she had had cervical cancer earlier in her life. The man with ankylosing spondylitis had a large basal cell carcinoma on his nose. A man who had chronic sciatic back pain, and also ulcerative colitis, which is known to be autoimmune in nature, developed colon cancer.

One man who was in his upper seventies had been my patient for twenty-one years. He was sick when he was a small boy and was severely sick when he was in the US Navy at the end of WW II. He had had a CABG in his early fifties when it was a new procedure. He developed Guillian-Barre' syndrome before I met him. He had an abdominal aneurysm that had been monitored for size. He had had back pain many times in his life. He developed a mesothelioma, a cancerous lesion with a pleural membrane source, in the lungs. He developed a pneumonia-like disease and thereafter developed renal failure and died. There is a reason for all of the medical conditions the above patients had had or developed: an underlying, inflammatory, autoimmune disease triggered by a certain reasonably-common microorganism.

A man had had back pain frequently in his life, and he had developed many, many skin cancers on his face, ears, and hands through the years. I did quite a bit of surgery removing them, from time to time, for many years. His wife had ulcerative colitis and severe femoral neuropathy. His son had chronic back pain (sciatica), that is, sacral plexus neuropathy. The man developed an infectious disease and I treated him at home. He was an old-time logger and didn't want to go to the hospital. Eventually he died of congestive heart failure. How could that have happened? Eventually all the puzzles, including the involvement of family members would be solved!

I worked and worked intensely, 12-14 hours a day for two and one-half years trying to “break the code”, so to speak, on this systemic disease process. Eventually I had a patient who moved here from Plano, Texas. She said she had fibromyalgia. She arrived taking Oxycontin 20 mg twice a day and Roxicet for breakthrough pain (Oh, crumb, another chronic pain patient!). Many of my other patients had had the same diagnosis before they came to my office. I never used the term fibromyalgia, because the anatomy and pathology of the disease had never been described accurately and the name reflected a symptom complex, only. On about the forth, monthly visit with the above patient, I realized she had the same dermatological abnormalities that many of my other patients who experienced neurological pain exhibited. I asked her when they appeared. She said they appeared when she contracted a certain infectious disease. Yo no podía creerlo. I had never treated that disease in my life! I went into my office and reviewed the disease in my texts, since I had not read about it since medical school. I then asked her what her symptoms and signs had been. Her description was perfect, right out of the text! Further research indicated that the microorganism causing the disease could possibly cause an autoimmune stimulation. Now, after a few years of academic research, I know it can cause autoimmune responses of many types and the various sub-types of the microorganism can probably cause different and specific autoimmune responses. Perhaps that variability is one of the reasons why endocrine and rheumatoid diseases have the clinical and serological variables that they do.

I did serological tests on the above woman and they were highly positive. I did serological tests on one-hundred, or so, other patients (those who could afford it) and a total of seventy were positive. I realized that the “normal” levels published by laboratories were skewed too high, because more people had the infectious disease than knew it and answered incorrectly on medical history forms when their blood was drawn, from which, the normal titers were determined! I interviewed the seven hundred patients as they came into my clinic monthly and many of them knew they had had an infection similar to that which I described when they were young or later in life. Many times their sickness was confused with the worst chicken pox, flu, mononucleosis, viral meningitis or measles that any one ever had had. It tended to be “within families” and I had families in my group of 700 wherein all members had had the infectious/autoimmune disease and the sequela to it. I learned clinically, and then from older medical literature, that the infectious disease and therefore the autoimmune response could be sub-acute or even chronic and last months and years. Even the carrier state, I think, can cause an autoimmune response!

Now, after two and one-half years, I finally I had a good mental grasp of the microorganism and the disease it causes and also the inflammatory, chronic autoimmune disease that followed persistently, that presents itself in a delayed fashion, initially as an autoimmune vasculitis. I learned how it could cause neuropathy, the rheumatoid diseases, cancer, arteriosclerosis, endocrine diseases, gastrointestinal diseases, dermatological diseases, somatic conditions, pulmonary diseases, including asthma and COPD, and many psychological and neurological conditions such as peripheral neuropathies, MS, probably ALS, autism, ADHD, PTSD, and others. Last year I discovered a book, “The Autoimmune Diseases” ( Rose and McKay, Elsevier Academic Press, 2006), and therein many of the “diseases” that I had discovered to be autoimmune in nature were also categorized as such in the text. Many, many facts, which are presented in texts like “Harrison's Principles of Internal Medicine” and the prior text, give support to my theory. I do not think there are any conflicts. In the latter text, “Harrison's”, one has to “go through the specialties” to glean out the relationships, but that is something a generalist in medicine, like I, have done for thirty years.

I have determined that the inflammatory autoimmune disease, stimulated by the microorganism in question, causes many of the physical and physiological changes that are thought to be the aging process. If a person gets cancer early in life, they had the infectious disease and the autoimmune response worse. If they get a myocardial infarction at thirty-eight, they just had the disease worse. Many people in my group of seven hundred had premature grey hair! The average age of the group of 700 patients was about forty-two, as I mentioned.

I sold my clinics two years ago after I was hassled by the State of Washington Department of Health since seven out of 7000 patients died over a three-year period. They died of complications connected with the infectious/autoimmune disease, not from any adverse treatment I had given. I had attracted a very ill patient group and had 7000 patients enrolled in my three clinics so the number was not so high from a statistical analysis. Since I was 65, I decided to sell my clinics and further my research from an academic approach. I learned, from experience, how academically weak bureaucratic physicians are and how they and other bureaucrats can use official connivance, modern rhetoric in the form of press releases and television announcements, and litigious muscle to further their ill-conceived goals.

Thereafter, I traveled to nine countries and visited clinics and hospitals and took medical histories on patients I met and examined them to some degree. I have continued to do academic research on what has become an abiding interest. I have completed a book of 180 pages, or so, and it is now being edited. I will publish it unless I make a connection with a pharmaceutical company or research institution that is interested in having me join them and investigate this disease further. If I do make a connection, I will wait to publish my book until a mutually appropriate time.

The human and other vertebrates have evolved with the microorganism in question, for millions of years. Vertebrate hosts have genetically evolved to counter the microorganism's antigenic aggression with an antibody response, but unfortunately for us and other vertebrates, the immunological response is an autoimmunological response and we humans and other vertebrates develop chronic autoimmune disease. We have learned, genetically, to counter the autoimmune disease reasonably successfully, however, and we, and members of our species, usually reproduce and maintain our populations, and the microorganism does the same. We have developed a semi-symbiotic relationship.

In history, there have been many epidemics and pandemics and I believe that during those times when environmental factors favored the microorganism, the infections caused acute and highly chronic inflammatory autoimmune disease (there are many autoantigens within the microorganism's structure) that led to the development of some of those pandemics. The Athenian Plague, 430 BC, the Black Plague of the 1300's and the Influenza of 1918 are examples, I believe. All the above great pandemics took place concomitantly with large military operations, the Peloponnesian War, The Thirty Years War, and of course WW I. The Thirty Years War took place at the time of the “mini-ice age in Europe” and the coolness and poor food supply probably was another adverse factor. There is very little sure knowledge concerning the identification of the pathogens that caused the above pandemics. Influenza, means “from the heavens” in Italian, for instance, and it has only of late become to be known as a disease caused by a virus, but again, that is not a sure thing in many cases, historically, since the electron microscope, which is needed to see viruses, was not invented until 1938.

I hypothesize that the microorganism of which I am speaking is the cause of those great medical disasters. The recent increase of fibromyalgia, autism, ADHD, PTSD, TB, MRSA, AIDs, MS, diabetes and cancer etc. are indicators that the autoimmune disease in question is “gaining ground” on the ability of humans to immunologically protect themselves in this temporal cycle. It is a good possibility! The microorganism is ubiquitous to all vertebrate society, so it is a bilateral zooinosis, so to speak, and there is a constant reservoir of organisms in vertebrate life around the world.

Various environmental conditions make the often-subtle infections more common. Living in economically poor societies, existing in crowded conditions, living in more soiled environments, and existing in cooler, damper environments all cause the disease to be more common. Within the military environment, especially overseas, two of the three factors, mentioned above, are prominent: living in crowded environments and living in economically poor societies. I am quite sure that the Vietnam Syndrome and the Iraq War Syndrome are manifestations of the underlying infectious and autoimmune disease of which I am writing.

It is common for those with the rheumatoid diseases, cancer and arteriosclerosis (and aneurysms) to have neuropathies. It is common for patients with AIDS to have neuropathies, rheumatoid diseases, cancer, psychological abnormalities including homosexuality, and other infections, as you know. Typical texts like “Harrison's Principles of Internal Medicine” mentions the associated problems, mentioned above, in AIDS patients, but also that they have rheumatological disease paradoxically! The rheumatoid diseases are known to be paraneoplastic, especially, dermatomyositis and Wegener's granulomatosis, but in my patients through the years, all patients that developed cancer had, at least, mild rheumatoid arthritis. Guillain-Barre' syndrome is a paraneoplastic disease also, and it is basically a wide-spread neuropathy, something like acute MS, which it surely is. Those diseases are thought to be paraneoplastic, because the underlying inflammatory, autoimmune disease causes the syndrome in question, but also the cancer that somewhat frequently appears with them.

The organism in question is endemic in society. It is ubiquitous in nature and I found information in Russian literature that all domestic animals have infections by and are carriers of this organism at various times in their lives. I believe all vertebrates, in general, suffer infections from and are carriers of, the microorganism in question, many times in their lives, also.

A prime concept is: from the first infection by the microorganism in question that a person has in their life, they develop the inflammatory autoimmune disease at some level. Additional infections cause an increase in the subtle, or not so subtle, autoimmune response! I think the genetics of the microorganism is varied enough to enable the organism “morph” with certain micro-environments so as to be able to exist in different micro-anatomical niches. The previous idea is a hypothesis, but it would be easy for a microbiologist to check.

As a side-note I will mention that I met a woman who lived on Vancouver Island, British Columbia. She developed cervical cancer during her late twenties and had the surgical treatment appropriate for that condition. Then, thereafter, she had breast cancer in her mid-forties. She had bilateral mastectomies and reconstructive surgery. While talking with her I learned that her father had been a Canadian Forces dentist. There is no place more likely to contract microbial disease, than working on people's teeth, daily! Her son had Asperger's syndrome, an autistic spectrum mental condition. Her father died of congestive heart failure caused by idiopathic cardiomyopathy, and a sister had neurofibromatosis, all caused, I believe, by this underlying autoimmune disease that is itself caused by the microorganism in question. The former condition, cardiomyopathy, is considered in the text, “The Autoimmune Diseases”, previously cited, to be of an autoimmune nature. The latter disease, neurofibromatosis (Von Recklinghausens's syndrome), is a disease with which I had only one patient, but I have connections to three others, and I think this underlying, inflammatory, autoimmune disease is connected to its pathogenesis.

I had a good friend, and about ten years ago he developed ALS and died. His mother died from MS. His wife had lumbar surgery for an alleged herniated disc that was not cured by surgery. The reality is that she had sacral plexus neuritis from the same underlying, chronic, inflammatory, autoimmune disease her husband had. My friend had certain mental characteristics connected to the autoimmune disease and, of course, he eventually presented with neurological symptoms consistent with ALS. His son had chronic seizures. These neurological syndromes, within families, again, are similar to those I noted, through the years, in my practice of medicine in Washington State.

Washington State, by the way, has, I believe, has the eighth highest attack rate for cancer considering all the states in the USA. It is well-known that the MS attack rate is high in northern tier countries and I know it is because infections by the microorganism in question are more common in cooler, more-damp locales. MS is common in my practice area. There is a semi-rural road just north of Toledo, Wa., a town with only 690 inhabitants, and three people who live thereon have MS and they are living within a half-mile of each other. Two other people who developed MS grew up close by! There has to be a logical reason! The reason is, no doubt, that they all went to the same schools and the microorganism in question was spread amongst the children as they attended school!

He mencionado las enfermedades infecciosas como el SIDA, el SARM y la tuberculosis, ya que no suelen ser muy contagiosa, pero con un relativamente alto grado de la enfermedad inflamatoria, autoinmune del sistema inmune protectora se degrada con el tiempo, permitiendo que estos patógenos relativamente leves a ser más invasivo y patológico. Existen otros agentes patógenos bacterianos, virales, parasitarias y por hongos, que pueden causar infecciones en las personas que están inmunológicamente deprimidos. Por ejemplo, tal vez el paludismo, la lepra, la enfermedad del sueño y muchas otras enfermedades virales son miembros del mismo subconjunto. En zonas como el África subsahariana, una localidad en la que la población sufre la enfermedad infecciosa objeto y la respuesta autoinmune a una frecuencia alta, es probable que la población, en su conjunto, probablemente tiene un grave deterioro con la respuesta inmune de modo que fácilmente contraer las enfermedades, que se menciona.

Además, a pesar de que las personas con SIDA tienen inmunodeficiencia debida a la acción patológica del virus del SIDA, los pacientes probablemente tenían deficiencia inmunológica de la enfermedad autoinmune que se trate y que permita el virus del sida para invadir inicialmente. Puede ser que algunas subespecies de Staphylococcus aureus son altamente resistentes a los antibióticos, incluyendo metacilina, ya que ha tenido la oportunidad de desarrollar genes que contribuyen a la resistencia a los antibióticos en los seres humanos, que han tenido la degradación del sistema inmunológico con anterioridad por la enfermedad autoinmune en la que se trate. Esta es otra hipótesis dentro de mi teoría, pero no tengo razones para ello, ya que muchos de mis pacientes desarrollaron infecciones inusuales y agresivos sobre todo si tenían la enfermedad autoinmune en serio.

Otra área de la medicina y el comportamiento humano que he tocado, por encima, es el desarrollo común de los estados de enfermedad psicológica y éstas se describen generalmente como el autismo, el TDAH, trastorno de estrés postraumático, esquizofrenia, depresión, enfermedad maniaco-depresiva, ansiedad crónica, la personalidad explosiva, la impulsado, personalidad tipo A, enfermedad de Alzheimer y la enfermedad de Parkinson (los dos últimos son probables). Otras anomalías, psicológicos y de personalidad más sutiles también son causados ​​por este proceso de la enfermedad autoinmune, como los déficits de aprendizaje. Además, el síndrome de fatiga crónica y quizás la anorexia nerviosa son causados ​​por este proceso de la enfermedad. Todas las condiciones anteriores como neuropatías centrales del sistema nervioso, es decir, centrales manifestaciones nervioso de un proceso sistémico autoinmune, enfermedad inflamatoria. La enfermedad inflamatoria autoinmune perturba la barrera sangre-cerebro permitiendo factores autoinmunes y otros factores de suero para entrar en los tejidos cerebrales y causar daño a los tejidos neurológicos. El momento de la vida, la gravedad, la cronicidad, los subtipos de microorganismo, la frecuencia de la infección, todo lo cual afecta a la respuesta autoinmune, y la capacidad de un sistema dado persona inmune a luchar contra la enfermedad infecciosa y la respuesta autoinmune, provoca la variación En ensayos clínicos de manifestaciones psicológicas se indica en las condiciones anteriores.

Para entender el proceso autoinmune sistémica enfermedad inflamatoria, uno tiene que salir mentalmente de la imagen de pensamiento a priori, que nosotros, los médicos, los científicos médicos y laicos-, han sido condicionados para pensar en el desarrollo de enfermedades. Durante sesenta años, por lo menos, hemos sido educados para pensar de acuerdo a las "divisiones especializadas de la medicina". El cuerpo humano no es, naturalmente, separados, convenientemente, en los sistemas, excepto como una herramienta para entender la anatomía en la formación médica como uno está aprendiendo el tema. Hay que pensar que el cuerpo reacciona: de una manera sistémica. Una persona debe darse cuenta de que no es una enfermedad infecciosa, que puede ser agudo e importante, o tan leves y crónicas que el paciente puede sentir normal, pero causa tanto de un ataque autoinmune inflamatoria, por lo general sutil, pero que puede ser agudo y grave. Incluso el estado de portador estimula una inmune y por lo tanto, una respuesta autoinmune. Uno tiene que darse cuenta de que el ataque autoinmune flujos y reflujos en el tiempo dentro del individuo en función del entorno microbiano en la que se vive y dependiendo de la respuesta inmune a la persona el proceso infeccioso y el proceso autoinmune.

Uno tiene que darse cuenta de que cada órgano de tejido y por lo tanto responder a lo patológico, el ataque autoinmune inflamatoria diferente. El corazón se desarrolla la arteriosclerosis, arritmias cardíacas, miocardiopatía y pericarditis, la piel se desarrolla la rosácea, eritrodermia, nevus araña, nevus, queratosis seborreica (marcas de la edad) y la dermatitis y encanecimiento del cabello. Los órganos del sistema gastrointestinal desarrollar esofagitis, úlceras, pólipos, divertículos, colangitis esclerosante primaria, colitis ulcerosa, enfermedad de Crohn, hepatitis autoinmune, la colecistitis y la pancreatitis. El cerebro se desarrolla alteraciones funcionales tales como el autismo, el TDAH, trastorno de estrés postraumático, esquizofrenia, fenómeno disociativo, el trastorno maníaco-depresión, la depresión, déficit de aprendizaje, trastornos de la personalidad, la enfermedad de Alzheimer y la enfermedad de Parkinson. Muchos seres humanos se encuentran en las cárceles y prisiones a causa de las anomalías de comportamiento que se desarrollan a partir de encefalitis autoinmunes. Los pacientes pueden desarrollar problemas de aprendizaje y una de las pérdidas pueden ser el aprendizaje moral. El sutil cambio mental que tiene lugar durante la pubertad pueden ser alterados y algunos individuos experimentan una transición a la disminución de la orientación heterosexual y la estancia no diferenciada en ese sentido, pero se desarrollan normales somáticas características secundarias sexuales, por lo que la persona homosexual se desarrolla. Una combinación de la personalidad explosiva, la orientación sexual desviada, y los patrones de pensamiento inmoral producir, creo yo, la personalidad criminal. Estamos condicionados a pensar que la gente es mala, pero creo que sufre de una orgánica, cerebritis inflamatoria, autoinmune, que hace que sus tendencias de comportamiento anormal.

Las disfunciones cerebrales de varias maneras, dependiendo del patrón de la enfermedad infecciosa y por lo tanto, la respuesta autoinmune, y cómo el ataque autoinmune se ha desarrollado. La mayoría de los niños con autismo son tratados por pediatras o neurólogos pediatras. Los pacientes que tienen la enfermedad de Parkinson son vistos por los neurólogos, internistas, psiquiatras o, por lo que las similitudes no se notan en la especialidad de la actual disposición, clínica. Si lo piensas bien, un niño con autismo de alto grado se comporta como una persona en miniatura con la enfermedad de alto grado de Parkinson. He tenido ambos tipos de pacientes en mi clínica y me sorprendió lo familiar que se encontraban. El niño con autismo tiene la hemofilia en el desarrollo debido a la enfermedad autoinmune en la pregunta también. La madre del niño tenía lupus eritematoso sistémico y la fibromialgia con neuritis braquial, ciática y la neuritis del plexo, la totalidad de una causa autoinmune. La madre del niño fue, sin duda, el "portador de microbios" que llevó a su hijo desarrollar una enfermedad autoinmune manifiesta por autismo severo (encefalitis autoinmune), a unos años de edad thee.

El árbol vascular desarrolla arteriosclerosis, aneurismas, flebitis, tromboflebitis, tromboembolismo y linfedema. El ataque autoinmune en las gónadas perturba la meiosis y la causa cambios genéticos que conducen a defectos genéticos de nacimiento. Un ataque de similares inflamatoria autoinmune de las células somáticas provoca aberraciones genéticas somáticas, que puede conducir al desarrollo del cáncer clínico. Los autoanticuerpos pueden pasar a través de la placenta y causar una gran variedad de defectos congénitos del desarrollo. Uno tiene que darse cuenta de ese fenómeno que aparece en los sistemas complejos aparecen en una forma más o menos al azar!

Las personas con dificultad para la cicatrización autoinmune inflamatoria enfermedad de la experiencia. La lenta unión o no unión de fracturas, la cicatrización lenta de las heridas quirúrgicas con el desarrollo de queloides, hernias incisionales, y las adherencias son comunes en este grupo. A veces las mujeres, si sufren una enfermedad autoinmune de alta calidad, puede pasar autoanticuerpos a través de la placenta y causar dificultad en el paladar embrionario de tejido plano para la fusión y fisura y la espina bífida, entre otros defectos congénitos del desarrollo, se puede desarrollar. Esta enfermedad infecciosa y la respuesta autoinmune es mucho más común en los "países del tercer mundo", como Vietnam, y por supuesto, hay muchas misiones a ese país para la reparación de paladar hendido y anormalidades del desarrollo en el corazón, por ejemplo.

Los pacientes y los médicos notan anomalías en los órganos de los sentidos especiales con mayor frecuencia. Los ojos de desarrollar cataratas, presbicia, degeneración macular, glaucoma, desprendimiento de retina, iritis, uveítis, el desarrollo penguecula, diplopía, escleritis y coroiditis, etc El sentido de la audición se desarrolla el tinnitus y disminución de la función. El nervio vestibular puede funcionar mal y el individuo puede desarrollar vértigo. Las alteraciones del nervio facial llevar a palsey Bell. La neuritis del trigémino autoinmune provoca dolores de cabeza por migraña. Reumatoide tempo-mandibular artritis causa dolores de cabeza y de la ATM no es inusual para ambos tipos de dolores de cabeza a existir simultáneamente, ya que ambas son causadas por la misma afección subyacente vasculitis autoinmune.

La mayoría de la gente ha oído hablar de los factores de riesgo de enfermedad arterial coronaria: una historia familiar positiva de enfermedad coronaria, personalidad tipo A, el colesterol alto, diabetes, hipertensión, pliegues transversales del lóbulo del oído (una idea de hace unos 15 años), y voy a mi anuncio propia: el dolor de espalda neurológica: la ciática. Los mismos factores de riesgo apto para aquellos con aneurismas de las arteriolas y la enfermedad vascular periférica. La realidad es que todos los marcadores o factores de riesgo son más que fenómenos concomitantes causadas por la enfermedad inflamatoria, autoinmune de la que estoy escribiendo. La historia familiar positiva no se debe a la genética, es porque los individuos dentro de las familias son más propensas a contraer la infección en cuestión, y por lo tanto desarrollan la enfermedad autoinmune, con más frecuencia.

He estado en Vietnam, Taiwán, México y recientemente por largos períodos de tiempo y sé que la enfermedad de base infecciosa y la respuesta autoinmune es más grave y endémico en los lugares económicamente más desarrollada que aquí, en Estados Unidos y en Europa Occidental. El microorganismo ha sido traído hasta aquí, incluyendo varias cepas que son más patológica, y tal importación ha causado un aumento en el interés común y la gravedad de la enfermedad autoinmune, es decir, de carácter sistémico, y por lo tanto las condiciones anteriores son más frecuentes que, vamos a nos dicen, hace 30 años. Hay otros factores que han provocado la infección y la respuesta autoinmune a ser más frecuentes, también.

Ser un médico general, y de haber trabajado en la Marina de los EE.UU. en los EE.UU. y el extranjero, o en ciudades pequeñas clínicas de toda mi vida profesional, así que no se han publicado en revistas académicas. Yo, sin embargo hablar en la Segunda Conferencia Mundial sobre enfermedades autoinmunes en Moscú, en septiembre pasado. Yo era un orador sustituto, porque tomó el lugar de un científico ruso que había tenido un ataque al corazón, en una tarde de uno de los últimos días. Creo que la mayoría de los "oyentes" fueron alergólogos pediátricos rusos, ya que patrocinó la reunión. La mayoría de los internacionales "académicos" se había ido, ya que estaban allí, básicamente, para dar a sus propias conversaciones. No estoy seguro de que muchos de los rusos comprendieron mi "Inglés rápido", ya que sólo tenía veinte y cinco minutos para hablar. Dado que este es un proceso de enfermedad sistémica, es naturalmente compleja. Por eso he escrito un libro para que yo pueda explicar más que muchos de los mecanismos de producción de la enfermedad en los diversos tejidos y órganos y la forma en que el subyacente, enfermedad sistémica, inflamatoria autoinmune juega un papel clave.

La mayoría de la investigación médica y científica, en la actualidad, se lleva a cabo a través de medios microscópicas o submicroscópicas. Los artículos en el 2000, más o menos, revistas médicas impresas en el mundo pueden dar fe de este hecho. La mayoría de los resultados de la investigación en realidad no afectan a la promoción práctica de la ciencia médica en la que el tratamiento de las enfermedades ha mejorado. Mi investigación fue de naturaleza macroscópica, clínica y epidemiológica. He utilizado la inducción de razonar y ver las relaciones entre las observaciones biológicas y clínicas que han hecho de ser médico. He visto 230.000 interfaces de los pacientes y que comprende un gran número de observaciones. Tuve un gran escenario, que es un propietario de una clínica independiente, en una zona pobre, durante casi un cuarto de siglo. Los pobres están más enfermos las personas, en general, y de ser un médico general, y tratar todas las enfermedades, "tuve la oportunidad de" armar el rompecabezas.

Otra de las ventajas que tenía, quizás, es que yo soy un ex oficial de la Marina EE.UU.. Yo era un piloto de Phantom II con 146 misiones de combate en la guerra de Vietnam. Al volar un avión de alto rendimiento, tuve que aprender a integrar un gran número de factores, a la vez, y tal vez me convertí en una especie de analista de sistemas, en 500kts con la gente disparando a mí! Infantes de Marina tienen un dicho: "Lo difícil lo hacemos inmediatamente, y lo imposible sólo tarda un poco más." Chistoso, que es, pero en Tarawa, Iwo Jima, y ​​otros lugares desagradables fueron tratados con éxito mediante la perseverancia más que la inteligencia. Mi investigación se llevó a una gran cantidad de perseverancia, un conocimiento experto de las entidades de muchas enfermedades, que se encuentra en una clínica durante un largo periodo, y vi, médicos, hombres y mujeres de todas las edades y para todas las enfermedades. Tuve la perseverancia y el sentido del deber a mis pacientes a trabajar 12-14 horas al día durante dos y medio años y, finalmente, que "descubrió" el enigma, el enigma!

El siguiente paso en la prestación de la garantía adecuada de que mi teoría es correcta, es que yo tendría que conectarse con un grupo de investigación que tiene una conexión con un gran hospital / clínica del sistema y coordinar las pruebas de serología y marcadores inflamatorios de las cohortes de pacientes. Patients with: breast cancer, colon cancer, brain cancer, leukemia, diabetes, Cushing's syndrome, Addison's disease, Polycystic ovary disease, Parkinson's disease, Alzheimer's disease, arteriosclerosis, stroke, hypothyroidism, ulcerative colitis, chronic pain from fibromyalgia and neuropathies, esophagitis, ulcers, AIDS, TB, MRSA, the rheumatic diseases, Crohn's disease, gastric ulcers, etc.

Perhaps fifty of each type of patient could be enrolled in the serological study. Phlebotomies could be organized through the hospital and clinic via a contractual agreement and each patient or caretaker could sign a permission slip for the test. Such testing is quite simple to organize, I think. If the serology results are positive, like they were in my own clinic, that is, if something like 60% of patients have elevated serology, the theory is proven. Antibody levels drop, over time, if a patient does not have an infection in the intervening period, but the immune system is still operating in a pathological way, even if the antibodies, that are also autoantibodies, are at a lower level. The patient is still immunologically primed to respond aggressively to repeated infection in the future. This is what causes exacerbations of rheumatoid arthritis, for instance, and why back pain exacerbates: because the autoimmune disease improves, to some degree, if a person does not have an infection, by the organism in question, for a certain period, and then if a new infection takes place the inflammatory autoimmune disease will become worse.

A person could elect to do further testing on a greater number and on more varied cohorts of patients, in addition, to make the proof more firm. Once the theory is proven, the research can start in an effort to make autoantigen, autoantibody and target-tissue blocking agents. The first and last are probably similar. A group of medications from the existing pharmacopeia can be developed to inhibit the autoimmune response. I had many, many patients on a selection of medications that helped without question. A vaccine can be developed!

Many people die early in life from cancer, heart disease, and aneurysm formation, because they, more or less, age early. The individual organs that develop clinical abnormalities from the underlying, inflammatory, autoimmune disease exhibit them with some randomness, which would be natural in a complex system. It is quite common, however, for a person to have low back pain, an explosive or driven personality (Type A), some arthritis in the knee, and experience an arthroscopic surgical procedure. Then later, arthritis in the hands may appear and then age marks (seborrheic keratosis) develop. The individual might have had nevi and need to watch for malignant melanoma. After a few years they have a myocardial infarction or angina and have a stent emplaced. Perhaps later, they develop atrial fibrillation, and then ten years later they get cancer. The temporal appearance of the diseases mentioned above, which are really target –organ manifestations of an underlying autoimmune disease, and are in the sequence I noted in the members of families in my area, among others. One phenomenon that takes place, that we just take for granted, is that as we age we get ruddy faces and graying of the hair. Both are manifestations of the subtle, autoimmune, inflammatory disease that we all have! The universal physical changes that all humans experience, commonly termed aging, are, for sure, for the most part, the physical manifestations of this underlying infectious/autoimmune, inflammatory process.

Like all break-throughs in science, I was the receiver of millions of bits of knowledge from my mentors through the years and then from my own clinical experiences. All the bits of “passed-on” knowledge ( I sound like Bill Gates=bits of knowledge) and personal medical observations led to a generalization. Like many new insights it is simple once it is understood, like: E=MC sq. Even the visualization of the disease mentally, is somewhat akin to Einstein's heuristic thoughts that led to the theory of special relativity.

Einstein escribió, el más simple de una teoría, y de las observaciones más que explica, lo más probable es que sea correcto (parafraseado). My theory is simple and it explains most of the puzzling observations I have had in medicine for over thirty years, and serological testing and the taking of medical histories proved it is correct.

James W. Goding, MD, Ph.D., Monash University, Australia, wrote in the epilogue of “The Autoimmune Diseases”, “Would the Real Autoantigen Please Stand Up!” He was referring to the concept that there was probably one autoantigen or group of antigens from one source that caused the autoimmune diseases listed in that long text. I have found it, I am very sure.

I know that many would think that I, being an sixty-eight year old osteopathic, general practitioner, may be one of the most unlikely medical professionals to develop a major insight in medicine! I was, however, the one independently seeing patients of both sexes, of all ages, for all diseases, in one community, for a long period, an unusual situation in medicine nowadays in the period of procedural, specialty-dominated medicine. In my setting, I alone had the responsibility to determine what was medically causing disease processes within my patients. I was an independent physician and worked in an economically poor area. I had the independence of thought, to determine what I have managed.

Also, one must realize that John Snow, a general physician in London, did an epidemiological study and determined that cholera was spread by water supplies before the microbiological theory was well developed. In addition, one must remember that Louis Pasteur and Claude Bernard were not connected to a research institute. One could consider that Walter Reed and his physician associates, Dr.Jesse Lazear and Dr. James Carroll, and even Dr. Carlos Findlay, the Cuban physician who advanced the theory that the mosquito transmitted yellow fever twenty years before Dr. Reed's research project, who together proved that Yellow Fever was spread via the mosquito, were simply general practice physicians. To tell you the truth, the division of medicine into specialties has harmed the discovery of disease processes because specialists, by concept and training, develop a constricted view of medical science and t times never see sick patients. Since this autoimmune disease presents primarily as a vasculitis, and since there are no vasculogists (a new word), no one would ever determine that people have a wide-spread, inflammatory, autoimmune, vasculitic disease!

To give you a better idea of how simple it is, just look in “Harrison's Principles of Internal Medicine, 16th Edition”, within the section that discusses rheumatoid arthritis. The information provided indicates that there is no known cause for rheumatoid arthritis (RA), and that it is a systemic, autoimmune disease that features arthritis, neuropathy, and vasculitis, and that it can cause organ infarction, even a myocardial infarction. Earlier editions (the 13th edition, for instance) also indicated that a feverish disease could cause an exacerbation of RA. Since myocardial infarctions are caused by arteriosclerosis, as a general disease process, other clinical manifestations are peripheral vascular disease, stroke, arterial aneurysms and venous abnormalities such as venous thrombosis. I just had to learn what caused the feverish disease that triggered exacerbations of RA, and put the puzzle together. Thereafter, I just had to add on the fact that most people who develop cancer have, at least, one of the rheumatological diseases, for instance rheumatoid arthritis, at least subtlety, and so there is no doubt that the rheumatoid diseases and cancer are caused by the same underlying autoimmune disease process.

Even Galen, the famous Greek physician, scientist and philosopher, in 200 AD, coined the word “rheumatism” because the word-root rheum means phlegm. He knew that respiratory infections that frequently caused expectoration (coughing up phlegm) and coryza (phlegm from the nose), led to a miserable, chronic condition in his patients. He termed it “rheumatismos” or in English, “rheumatism”. Yes, arteriosclerosis, cancer, the endocrine diseases, the rheumatoid diseases, peripheral and central neuropathies and many more conditions are part of the rheumatism concept. They are all end-organ manifestations of the systemic, autoimmune, inflammatory disease of rheumatism!

Philology, the science of language, has, over hundreds of years, incorporated a great amount of wisdom within itself . In the Webster's New Twentieth Century Dictionary, 1976, it mentions under the word rheumatism: “any of various painful conditions of the joints and muscles; especial y, a disease believed to be caused by a microorganism and characterized by inflammation and pain in the joints.”

The “nut” of my theory has been known for thousands of years, but now with added, more recent knowledge from bacteriology, immunology, and the autoimmune concept, and by thinking systemically, as I saw my patients, especially during the clinical, epidemiological investigation I have mentioned, the nature of the disease process let itself be known.

I have presented the case for a disease that is so common, since it is caused by a microorganism ubiquitous to the society of vertebrates, and the autoimmune, inflammatory affects so universal, that we all have it. You, me, my kids, my ex-wife, my neighbors (I know the family: Dad has Charcot-Marie-Toothe syndrome (high arches and neuropathy of the legs), a cardiac stent and then a CABG and between the two was in the hospital for 8 days for “pneumonia with complications”, which was really a disease episode from the organism in question. Both his sons have the disease quite meaningfully as they have chronic pain and peripheral neuropathies. All of us humans in the world have the disease, because the organism is so ubiquitous. Some people and families have it worse, naturally. Those individuals and families often do not function well in life.

Since I have finished a book of approximately 200 pages concerning this disease process I could naturally write on and on. I will not, however, but I will say this: Over the last fifteen years there has been a great increase in the number of cancer, fibromyalgia, chronic pain, and autistic patients and the appearance of many infections such as TB, syphlis, MRSA, etc., in the American scene, of which I am most familiar. There has also been special manifestations of diseases, psychological and physical, in military men returning from overseas duty, especially from Vietnam and the Middle East. The reason this is true, I believe, is that the pathogens that cause the diseases are more common in poor societies and we, by our war activities, make the disease more manifest in the civilians in the war zone and within our own troops. In addition, infections by the microorganism and therefore the autoimmune response has become more meaningful in American society due to the immigration of ten million people from Mexico and Southeast Asia. Frequent international air travel has introduced microorganisms, or more pathological strains of microorganisms, into our country also.

Hopefully, you have found this letter a little entertaining and interesting. I think I am correct concerning the principles of my theory. I have interviewed, medically, over two hundred and thirty thousand patients during 30 year practice period. I was a physician in medicine, with a wide interest and the responsibility for treating my patients with all medical problems. I practiced in an economically poor area, with quite a few Mexican immigrants, so the markers of disease appeared more overtly than in a more affluent community. I have proved my theory via serological testing. I spent nine months visiting nine countries to determine that this disease process is world-wide. I am presenting a new generalization in medicine, a unifying theory of most or many of the idiopathic disease entities that have filled medical books for decades. The guiding theory, and the pathological and immunological principles that support it, will enable medical scientists to “focus” on the cause of diseases (really target-organ manifestations of an underlying autoimmune disease) and not just try this or that random molecule via a clinical trial, to see if it works on this or that malady.

I have had trouble relaying my information to a research organization because I am semi-retired, sixty-eight, an osteopathic general practitioner, and not an allopathic physician, because I have never worked in a research organization and I have not had any research published. Really, I have found that most individuals, who are in investigative organizations, are typically comfortable dealing with professionals similar to themselves and are not overtly open to new ideas from a person not currently in the structured research industry. Naturally, I can understand such reluctance. The reality is, however, millions of researchers world-wide are usually working with a similar mental-set, using similar techniques and intellectual approaches, and the results of research leaves something to be desired since there have been no “major” breakthroughs detailing the cause of a major diseases in decades!

I am interested in collaborating with a research organization that can help further prove my theory and develop the pharmaceuticals needed to control the disease process. I think that the pharmaceuticals will surely be the most helpful to members of human society, and therefore the most profitable, in the history of medical treatment!

I have been a solo practitioner in a small town most of my medical career and have not associated with other physicians much. I have, however, an old professional and personal friend, Albert Mark, who I have known since I was 16, since I worked for him when he was an active pharmacist. His phone is 1-425-454-0300. His e-mail is: AMMark914@gmail.com . You are free to talk to him concerning me, my background, and my ethics. In addition, I still communicate with my anatomy professor from medical school, Jack Julyan, PhD. His e-mail is carol@julyan.org . He knew me quite well and he was a great teacher.
.
Gracias por leer esta carta. If you have any interest, please contact me at: ecnal-c@hotmail.com , or 360-864-4371. My address is PMB 227; 120 State Ave. NE, Olympia, Wa., 98501

Atentamente,

Lance W. Christiansen, DO

Atentamente,

Lance Christiansen, DO.