Kommersialisere bioteknologi i Kina

Kjære Dr. Gingras,

Jeg har vært lege for en lang periode. Jeg har gjennomført en undersøkelse og har lært årsaken til mange idiopatisk sykdommer, inkludert perifere nevropatier, sentrale nevropatier, åreforkalkning, kreft og andre. Jeg innser at min påstand lyder pompøs, men som de fleste ting, er det enkelt når de prinsipper som er "funnet ut".

Jeg leter etter en "sted å ytterligere bevise min teori" og deretter utvikle og produsere autoantistoff betablokkere for å kontrollere den underliggende autoimmun sykdom som fører til mål-orgel manifestasjoner, vanligvis antatt å være sykdommer.

Jeg fastsatte den natur mikroorganismen som utløser sykdommen prosessen, i hovedsak.

Hvis du har interesse i å lære mer kontakt med meg på min e-post stedet.

Jeg har vært i USMC, i Vietnam som en pilot og arbeidet også i Japan for et år. Jeg har vært i Taiwan, men ikke fastlands-Kina. Jeg ønsker å jobbe der selv.

Jeg eide tre klinikker på en gang, men nå er jeg semi-pensjonert og gjør akademisk forskning for å forsterke den kliniske undersøkelsen jeg gjorde over en tre års periode. Jeg vil legge et papir hvis jeg kan.

En Unifying Theory of Diseases,

Autoimmune-sykdom og Target-orgel manifestasjoner

Jeg er en allmennpraktiker i medisin, og jeg har, jeg er sikker, utviklet en meningsfull innsikt i årsaken til mange, hittil, idiopatisk sykdommer. Idiopatisk sykdommer har blitt beskrevet med økende frekvens de siste seksti år etter de fleste smittsomme sykdommer ble forstått og kontrolleres med antibiotika av første halvdel av 1900-tallet. Nå har medisinske tekster blitt fylt med beskrivelser av tusenvis av idiopatisk sykdommer, de sykdommer uten kjent årsak, og siden deres årsaker ikke er kjent av behandlinger for dem er sykdom endrer ikke sykdom herding.

Overraskende, mest idiopatisk sykdommer er target-organ manifestasjon av en systemisk, inflammatorisk, autoimmun-sykdom prosess. Den autoimmune-sykdommer er forårsaket av en inflammatorisk, autoimmun tilstand, som selv er forårsaket eller utløst av en infeksjon med en mikroorganisme. Det er en mikroorganisme som er ganske vanlig og det er allestedsnærværende å bestander av virveldyr, som omfatter husdyr og mennesker. Med det i tankene, kan en person vurdere sykdommen en bilateral zooinosis.

Noen target-orgel manifestasjoner av autoimmun sykdom prosessen blir ofte bemerket dermatologisk. Medisinsk observatører vanligvis ikke tror at dermatologiske funksjoner som Nevi, tynning av hud og rynker formasjon, seboreisk keratose, angiomas, seboreisk dermatitt, eksem, poliosis, gråning av håret, osv. er nødvendigvis patologisk i naturen. Ofte er de antatt å være en del av aldringsprosessen. Hvis, derimot, utvikler en person koronarsykdom, kreft, grønn stær, gnagsår steiner, en revmatisk sykdom eller diabetes, som de blir eldre, og problemet kan være lokalisert til en viss organ ved en prosedyregenerert utdannet spesialist, er tenkt å være en spesifikk sykdom der det er virkelig et mål-organ manifestasjon av systemisk, autoimmun-mediert sykdom prosess.

Jeg, jobber som fastlege, fast bestemt på at de fleste idiopatisk sykdommer er target-orgel manifestasjoner av en systemisk, inflammatorisk autoimmun sykdom prosess. Ved å ha en annen utdanningsbakgrunn (del av det i luftfarten systemanalyse) og klinisk tilnærming til medisin, og ved å behandle menn og kvinner, i alle aldre, for alle sykdommer, kunne jeg ha innsikt som førte til en ny filosofi om sykdom utvikling, en som forklarer årsaken til de fleste idiopatisk sykdommer inkludert mange hudsykdommer, gastrointestinale sykdommer, nevrologiske sykdommer, kreft, åreforkalkning, de revmatiske sykdommer, og endokrine sykdommer, som til sammen kan tenkes å være en stor del av prosessen med aldring .

Jeg så mer enn 230 000 pasientbesøk, inkludert 1000 hjemmebesøk, i en fattig, semi-rurale logging samfunn uten moderne industri. Over en lang periode bemerket jeg visse kombinasjoner av sykdommer innen medlemmer av familier i opptil fire generasjoner. På grunn av at fenomenet, og på grunn av hyppigheten av MS og perifere nevropatier i mitt lokalsamfunn, bestemte jeg meg for å gjøre en klinisk og epidemiologisk undersøkelse. Informasjonen i de følgende sidene forklarer søket mitt, noen av mine funn, og noen ting som er aktuelle i fremtiden. Jeg har ikke nevnt identifikasjon av mikroorganismen som utløser den autoimmune responsen siden at informasjon er min proprietær kunnskap på dette tidspunktet. Takk for at du leser denne lange brev / papir, på forhånd.

Jeg har vært en militær og sivil lege for trettien år, en klinisk medisinsk teoretiker for de tre siste årene av min praksisperiode, og en akademisk etterforsker for de siste tre årene.

Noen fag har opplevd quantum gjennombrudd i det siste, for eksempel, fysikk (pun intended), fysisk kjemi, astronomi og kosmologi, laser vitenskap, immunologi og kanskje til og med den innsikten som førte til transistor og digital computer-kode konsepter, som deretter førte til "datarevolusjonen". Medisin, som en vitenskapelig bestrebelse, har opplevd mange gjennombrudd historisk, men ingen av teoretisk art som beskriver årsaker til sykdommer siden slutten av 1700-tallet eller kanskje tidlig på 1800-tallet, da den hypotesen og deretter teorien utviklet at mikroorganismer kan forårsake sykdom. At oppdagelsen førte til innsikt, noe som resulterte i utviklingen av antibiotika i 1930-årene og 1940-tallet. Det oppdagelse var trolig den siste store gjennombruddet i medisin!

Som du vet, har diagnostikk og behandling innsatsen blitt utviklet i løpet av de siste seksti årene, ved å låne fra andre høyteknologiske områder som elektronikk, laser vitenskap, ultralyd, biokjemi, og datateknikk, men ikke fra innsikt bestemmes direkte fra teoretisk medisin, som kunne gi en direkte tilnærming til naturen av sykdomsutviklingen og dermed dens behandling. Det er mange high-tech utstyr for å minimere påvirkningen av sykdom på en bestemt organ eller for å få en mer sikker diagnose, men enda en gang, det påvirker sykdommer blir endret, og de blir ikke vitenskapelig kontaktet av første bestemme deres årsaker .

Utviklingen av vitenskapen om genetikk, stilk-cellen begreper, og andre nye begreper i biologi, gytt ideen om at bruk av slike meningsfulle og ofte komplekse funn vil føre til en ny behandling for "den eller den sykdommen" selv om årsaken til Sykdommen er ikke kjent. Det synes alltid å være en ny "årsak celebre" i medisin.

I løpet av de siste tre årene av min praksis-periode, gjennomførte jeg en epidemiologisk, klinisk undersøkelse, og deretter har jeg gjennomført en to års epidemiologisk, akademisk og historisk medisinsk forskningsprosjekt, de data som, overveldende støtter min teori. Over en ni måneders periode reiste jeg til ni land og besøkt klinikker og sykehus og snakket med og undersøkt folk jeg møtte på de ulike stedene. Jeg har forsikret meg om at den mikrobielle infeksjoner og autoimmune sykdommer som det utløser, noe som fører til mange typer end-orgel manifestasjoner, inkludert kreft, åreforkalkning, fødselsdefekter, og revmatiske sykdommer, for eksempel, er en som eksisterer over hele verden, som jeg hadde en teori, men selvfølgelig er det mer alvorlig i enkelte steder i verden enn andre.

En del av mine tankeprosessene involvert innsikt som oppstod under den lange historien om medisin og hvordan de medisinske begrepene sykdom formasjon og behandlinger for dem har utviklet seg gjennom tiden. Som du vel vet, forårsaket infeksjonssykdommer store helsemessige problemer for menneskeheten for utallige århundrer, men fremveksten av mikrobiologi og deretter oppdagelsen av hygieniske teknikker og antibiotika, i midten av 1800-tallet til midten av 1900-tallet, redusert hyppigheten og viktigheten av smittsomme sykdommer . Før perioden nevnt, var selv sykdommer forårsaket av mikroorganismer idiopatisk i naturen.

Siden 1930-tallet, da antibiotika ble først brukt klinisk, medisinske tekster har "blitt dominert" av beskrivelser av forhold som er virkelig idiopatisk sykdommer: kreft, perifere nevropatier, åreforkalkning, de ulike revmatiske sykdommer, de ulike endokrine sykdommer, osteoporose, Alzheimers sykdom, Parkinsons sykdom, autisme, ADHD, PTSD, fibromyalgi og mange flere sykdommer av denne typen. Disse, og sannsynligvis 2000 flere idiopatisk sykdommer, blir kategorisert innenfor medisinske tekster, for eksempel "Harrison prinsipper for Internal Medicine" og være idiopatisk, er det ingen kjent årsak til noen av dem. Dersom årsakene til sykdommene ikke er kjent, behandlinger er sykdom endring, ikke sykdom herding, mesteparten av tiden. Som et eksempel på denne situasjonen, er det vanlig å fjerne en persons galleblæren skyldes betennelse, men kirurger sjelden spør hvorfor galleblæren var betent i første omgang! Pasienter med MS har markører på inflammasjon og calcific innskudd i det sentrale nervesystemet, men sjelden praktiserte nevrologer alvor forsøke å finne årsaken til MS. Pasienter som har kreft har ofte nevrologiske smerter, men ingen vet hvorfor de har slik smerte. Pasienter med AIDS ofte får revmatiske lidelser, nevropatier, infeksjoner og kreft, men lite er kjent hvorfor de alle eksisterer i det undergruppe av pasienter.

Jeg har bestemt årsak, en underliggende systemisk årsak, for de fleste av idiopatisk sykdommer, og jeg har gitt en beskrivelse av funn min, nedenfor. Man kan si at jeg har oppdaget en samlende teori om idiopatisk sykdommer, for det ville være statistisk uvanlig, og kanskje umulig, for det å være 2000 årsaker for 2000, eller mer, sykdommer som fyller medisinske tekster og med hvilke leger og medisinske etterforskere håndtere, og blir forvirret av, daglig.

Jeg har vært en generell praksis lege, både i den amerikanske marinen og i det sivile liv i nesten tretti år, men de siste seks årene, er den beste beskrivelsen av mine aktiviteter som jeg har jobbet som en teoretisk, medisinsk etterforsker. Jeg var en jagerflypilot i USA Marine Corps, overraskende, i løpet av mine slutten av tyveårene og begynnelsen av trettiårene, og så, siden jeg opprinnelig hadde en grad i biologi fra Whitman College, jeg re-utdannet meg ved å ta pre-medisin studier ved University of Washington og medisinske skolen ved Chicago College of Osteopathic Medicine, i en medisinsk karriere. Jeg øvde medisin i Sjøforsvaret som en generell medisinsk offiser / flytur kirurg i fem år under aktiv tjeneste og i fem år som Reservist. For tjuetre år, deretter var jeg en liten by allmennpraktiker. Jeg har alltid jobbet mentalt i et forsøk på å finne årsakene til sykdommer, fordi jeg tenkte en del av min plikt som lege skulle være en lege-etterforsker, samt en være en kliniker og behandlende lege.

Jeg øvde i en semi-landlig område sørvest Washington i over tjue år. Jeg var en mindre entreprenør i medisin, for jeg utviklet tre klinikker og hadde tre legens assistenter som hjelper meg, men jeg personlig så de fleste av alvorlig sykdom sakene. Jeg hadde en total registrering på 7000 pasienter i mine klinikker, så jeg hadde en stor mengde saker. Jeg prided meg selv, etter at jeg hadde en rekke års erfaring, i behandling av alle typer medisinske problemer, for både menn og kvinner, i alle aldre, og ikke opptre som et transportbånd og sende pasienter med meningsfulle sykdommer til spesialister. Naturligvis, henvises jeg pasientene til spesialister for større kirurgi, intern omfang, bildebehandling prosedyrer, og ICU sykehusinnleggelse siden jeg praktisert for langt fra et sykehus å ha en slik praksis. En slik opplevelse i medisin er ikke vanlig i dag, siden i femti år eller mer legemidlet er fragmentert i kunstig saksbehandlingsfeil, alder-definert, orgel orientert, system-relatert, sykdom relatert, og politisk bestemte (familie praksis) spesialiteter.

Etter å ha sett pasienter om tjuefem år ble jeg litt innadvendte og innså at hvis en pasient hadde hatt en forstuing, en rift, eller en sprekk, eller hvis de hadde hatt en infeksjon, var nesten hele resten av de medisinske problemene pasientene opplevde idiopatisk (deres årsaker ikke er kjent!). Jeg innså at de fleste behandlinger for idiopatisk forholdene hadde blitt utviklet ved prøving og feiling metoder gjennom tidene og den moderne versjonen av dette arbeidet er "Kliniske studier" som du er, ingen tvil, svært kjente. Det var situasjoner der behandler de ovennevnte forhold, rifter, brudd, forstuinger, og infeksjoner, ble komplisert. Langsom tilheling av sår eller kirurgiske områder med dannelsen av operasjonssåret brokk, var keloid utvikling (store arr) og interne adhesjon vanlig. De uorganiserte eller forsinket-forening av frakturer, og forstuinger som forårsaket kroniske smerter og hevelse i måneder og noen ganger år skjedde noe ofte. Til tider var en annen "idiopatisk sykdom navn" brukes for å forklare pasientens kroniske smerter: refleks sympatisk dystrofi eller komplekst regionalt smertesyndrom. Ingen sikker forklaring på årsaken til disse syndromer hadde fått, nøyaktig, i medisinske tekster. Også noen infeksjoner er svært vanskelig å behandle selv med eksisterende antibiotika. Det syntes å være noe okkult skjer.

Jeg jobbet i en logging og millwork område. Jeg øvde i den lille byen Toledo, Washington etter at jeg var en Navy lege, fordi eieren, som hadde hatt hjertestans by-pass kirurgi ønsket å fratre og han "solgt ut" til meg for ingenting ned. Jeg ønsket å være litt isolert fra "spesialitet medisin" fordi jeg ikke ønsket være, rett og slett, en pasient transportbånd som jeg hadde vært i marinen. Vel, jeg sikkert ikke var et transportbånd og jeg var opptatt fra første dag hvor jeg så førti-seks pasienter i en 12 timers skift. Jeg jobbet nesten like stødig i 21 år.

I løpet av de siste fem eller seks år bestemte jeg meg for at nevrologisk lumbar og cervical spinal smerte var ikke, mesteparten av tiden, forårsaket av herniated ryggrad. Det var sjelden at en pasient bedre, i en rimelig tid, etter at korsryggen eller cervical spinal kirurgi! Jeg behandlet mange, mange tilfeller gjennom årene. Jeg bestemte meg for å gjøre en epidemiologisk, klinisk undersøkelse og prøve å finne ut den "egentlige årsaken" for lumbalt / rumpeballe smerte og nevropati til underekstremitetene og skulder / nakke smerter og nevropati til den øvre ytterpunkt. Lite visste jeg at jeg ble involvere meg i en mange årig prosjekt!

Over en to og et halvt års periode tiltrakk jeg nesten 700 elendige, smertefulle pasienter på grunn av alvorlig perifer nevropati som de led. One might consider them to be the “worst end of the bell-shaped curve”. Many of the patients, probably 40% had had spinal surgery and some patients suffered many, many surgeries. A woman patient had had four cervical surgeries and three lumbar surgeries performed by the same neurosurgeon! She was no better for her experiences. One man had had experienced eight lumbar surgeries and was not any better, either. It was common to have neurological problems in one lower and one upper extremity and at times in all four extremities. It was somewhat common for many members in a given family to have neurologically caused lower or upper back pain! It seemed that there was a systemic, somewhat contagious, occult, disease process going on, but somehow it localized in the nerves of the lumbar/buttock and the shoulder/cervical area.

During my clinical, epidemiological investigation, I used the techniques any physician could use. I did physical examinations and analytic, neurological physical examinations on my patients, but I used them intensely and repeatedly. I did personal and family medical histories intensely and repeatedly, also. I determined that the neurological problems were located deep in the buttock and shoulder, and not in the spine! I realized that pain is just one manifestation of inflammation (dolor, rubor, tumor, calor = from medicine 101), but I did not know what caused the inflammation.

I realized that these severely painful patients had similar dermatological abnormalities, and most had some kind of rheumatological malady. Rheumatoid arthritis, a history of juvenile rheumatoid arthritis, lupus erythematosis, scleraderma, Wegener's granulomatosis, Sjorgen's syndrome, mixed connective tissue disease, ankylosing spondylitis, and psoriasis, were all represented within the group. Naturally, mild rheumatoid arthritis was the most common. I realized that these diseases were all inflammatory and autoimmune in nature.

Many patients had an endocrine condition: hypothyroidism, hypoparathyroidism, Addison's disease, Cushing's syndrome, diabetes, pituitary, testicular and ovarian abnormalities were common. I realized that many of these diseases were also autoimmune in nature.

I did a search of medical literature and found the malady of autoimmune-mediated neuropathy. I realized that my patients had that problem: autoimmune-mediated, vasculitic neuropathy. The findings came from the Mayo Clinic Peripheral Nerve Group and Weill Medical College, which is a part of Cornell University.

Eventually, I learned how the autoimmune-mediated vasculitic neuropathy could be traumatically exacerbated, locally, and caused the somewhat-focused pain deep in the lumbosacral/ buttock area and the shoulder/cervical area. The pathology was not located in the lumbar or cervical spine, as I mentioned above, whereat surgical procedures are focused, but referred pain patterns made the pain radiate into those spinal areas. There are a few herniated discs I suppose, but not many. Surgery for them, however, is quite common! With a touch of sarcasm I will say that some time ago, well-meaning and reputable physicians bled patients for all kinds of problems, too.

As I kept on working on the problem, I attracted more and more patients, and eventually I realized that many patients had had or developed cancer while I was seeing them. Seventy, out of seven hundred, miserable, painful, patients who came to see me due to chronic painful neuropathies, had had or developed cancer. The average age was about 43, or so, and all types of cancers were represented, but of course, the most common kinds such as breast, cervical, skin, and colon were the most common.

Some patients had had many cases of cancer. One woman who was born in Manitoba, who I interviewed where she lived on Vancouver Island, had had four major cancers and I noted that she had a squamous cell carcinoma on her face during my first interview. She had had cervical cancer, breast cancer, colon cancer, and then another breast cancer, and squamous cell cancer, over a thirty-year period. There is no way a person could develop five cancers unless there was an underlying disease process stimulating the pathological, somatic, genetic changes. I learned that she became severely ill with an infectious disease at the hospital where she was born and was not expected to live. She was “tagged” with an autoimmune disease nearly from birth and developed the five cancers secondary to the autoimmune, inflammatory assault during her lifetime!

Another woman, who was in chronic pain for previously diagnosed fibromyalgia developed a sarcoma on her anticubital fossa (anterior side of the elbow) as I was seeing her. Another woman had developed Paget's breast cancer and chronic lymphocytic leukemia, over a three-year period. The patient with Wegener's granulomatosis developed leukemia and she had had cervical cancer earlier in her life. The man with ankylosing spondylitis had a large basal cell carcinoma on his nose. A man who had chronic sciatic back pain, and also ulcerative colitis, which is known to be autoimmune in nature, developed colon cancer.

One man who was in his upper seventies had been my patient for twenty-one years. He was sick when he was a small boy and was severely sick when he was in the US Navy at the end of WW II. He had had a CABG in his early fifties when it was a new procedure. He developed Guillian-Barre' syndrome before I met him. He had an abdominal aneurysm that had been monitored for size. He had had back pain many times in his life. He developed a mesothelioma, a cancerous lesion with a pleural membrane source, in the lungs. He developed a pneumonia-like disease and thereafter developed renal failure and died. There is a reason for all of the medical conditions the above patients had had or developed: an underlying, inflammatory, autoimmune disease triggered by a certain reasonably-common microorganism.

A man had had back pain frequently in his life, and he had developed many, many skin cancers on his face, ears, and hands through the years. I did quite a bit of surgery removing them, from time to time, for many years. His wife had ulcerative colitis and severe femoral neuropathy. His son had chronic back pain (sciatica), that is, sacral plexus neuropathy. The man developed an infectious disease and I treated him at home. He was an old-time logger and didn't want to go to the hospital. Eventually he died of congestive heart failure. How could that have happened? Eventually all the puzzles, including the involvement of family members would be solved!

I worked and worked intensely, 12-14 hours a day for two and one-half years trying to “break the code”, so to speak, on this systemic disease process. Eventually I had a patient who moved here from Plano, Texas. She said she had fibromyalgia. She arrived taking Oxycontin 20 mg twice a day and Roxicet for breakthrough pain (Oh, crumb, another chronic pain patient!). Many of my other patients had had the same diagnosis before they came to my office. I never used the term fibromyalgia, because the anatomy and pathology of the disease had never been described accurately and the name reflected a symptom complex, only. On about the forth, monthly visit with the above patient, I realized she had the same dermatological abnormalities that many of my other patients who experienced neurological pain exhibited. I asked her when they appeared. She said they appeared when she contracted a certain infectious disease. I was incredulous. I had never treated that disease in my life! I went into my office and reviewed the disease in my texts, since I had not read about it since medical school. I then asked her what her symptoms and signs had been. Her description was perfect, right out of the text! Further research indicated that the microorganism causing the disease could possibly cause an autoimmune stimulation. Now, after a few years of academic research, I know it can cause autoimmune responses of many types and the various sub-types of the microorganism can probably cause different and specific autoimmune responses. Perhaps that variability is one of the reasons why endocrine and rheumatoid diseases have the clinical and serological variables that they do.

I did serological tests on the above woman and they were highly positive. I did serological tests on one-hundred, or so, other patients (those who could afford it) and a total of seventy were positive. I realized that the “normal” levels published by laboratories were skewed too high, because more people had the infectious disease than knew it and answered incorrectly on medical history forms when their blood was drawn, from which, the normal titers were determined! I interviewed the seven hundred patients as they came into my clinic monthly and many of them knew they had had an infection similar to that which I described when they were young or later in life. Many times their sickness was confused with the worst chicken pox, flu, mononucleosis, viral meningitis or measles that any one ever had had. It tended to be “within families” and I had families in my group of 700 wherein all members had had the infectious/autoimmune disease and the sequela to it. I learned clinically, and then from older medical literature, that the infectious disease and therefore the autoimmune response could be sub-acute or even chronic and last months and years. Even the carrier state, I think, can cause an autoimmune response!

Now, after two and one-half years, I finally I had a good mental grasp of the microorganism and the disease it causes and also the inflammatory, chronic autoimmune disease that followed persistently, that presents itself in a delayed fashion, initially as an autoimmune vasculitis. I learned how it could cause neuropathy, the rheumatoid diseases, cancer, arteriosclerosis, endocrine diseases, gastrointestinal diseases, dermatological diseases, somatic conditions, pulmonary diseases, including asthma and COPD, and many psychological and neurological conditions such as peripheral neuropathies, MS, probably ALS, autism, ADHD, PTSD, and others. Last year I discovered a book, “The Autoimmune Diseases” ( Rose and McKay, Elsevier Academic Press, 2006), and therein many of the “diseases” that I had discovered to be autoimmune in nature were also categorized as such in the text. Many, many facts, which are presented in texts like “Harrison's Principles of Internal Medicine” and the prior text, give support to my theory. I do not think there are any conflicts. In the latter text, “Harrison's”, one has to “go through the specialties” to glean out the relationships, but that is something a generalist in medicine, like I, have done for thirty years.

I have determined that the inflammatory autoimmune disease, stimulated by the microorganism in question, causes many of the physical and physiological changes that are thought to be the aging process. If a person gets cancer early in life, they had the infectious disease and the autoimmune response worse. If they get a myocardial infarction at thirty-eight, they just had the disease worse. Many people in my group of seven hundred had premature grey hair! The average age of the group of 700 patients was about forty-two, as I mentioned.

I sold my clinics two years ago after I was hassled by the State of Washington Department of Health since seven out of 7000 patients died over a three-year period. They died of complications connected with the infectious/autoimmune disease, not from any adverse treatment I had given. I had attracted a very ill patient group and had 7000 patients enrolled in my three clinics so the number was not so high from a statistical analysis. Since I was 65, I decided to sell my clinics and further my research from an academic approach. I learned, from experience, how academically weak bureaucratic physicians are and how they and other bureaucrats can use official connivance, modern rhetoric in the form of press releases and television announcements, and litigious muscle to further their ill-conceived goals.

Thereafter, I traveled to nine countries and visited clinics and hospitals and took medical histories on patients I met and examined them to some degree. I have continued to do academic research on what has become an abiding interest. I have completed a book of 180 pages, or so, and it is now being edited. I will publish it unless I make a connection with a pharmaceutical company or research institution that is interested in having me join them and investigate this disease further. If I do make a connection, I will wait to publish my book until a mutually appropriate time.

The human and other vertebrates have evolved with the microorganism in question, for millions of years. Vertebrate hosts have genetically evolved to counter the microorganism's antigenic aggression with an antibody response, but unfortunately for us and other vertebrates, the immunological response is an autoimmunological response and we humans and other vertebrates develop chronic autoimmune disease. We have learned, genetically, to counter the autoimmune disease reasonably successfully, however, and we, and members of our species, usually reproduce and maintain our populations, and the microorganism does the same. We have developed a semi-symbiotic relationship.

In history, there have been many epidemics and pandemics and I believe that during those times when environmental factors favored the microorganism, the infections caused acute and highly chronic inflammatory autoimmune disease (there are many autoantigens within the microorganism's structure) that led to the development of some of those pandemics. The Athenian Plague, 430 BC, the Black Plague of the 1300's and the Influenza of 1918 are examples, I believe. All the above great pandemics took place concomitantly with large military operations, the Peloponnesian War, The Thirty Years War, and of course WW I. The Thirty Years War took place at the time of the “mini-ice age in Europe” and the coolness and poor food supply probably was another adverse factor. There is very little sure knowledge concerning the identification of the pathogens that caused the above pandemics. Influenza, means “from the heavens” in Italian, for instance, and it has only of late become to be known as a disease caused by a virus, but again, that is not a sure thing in many cases, historically, since the electron microscope, which is needed to see viruses, was not invented until 1938.

I hypothesize that the microorganism of which I am speaking is the cause of those great medical disasters. The recent increase of fibromyalgia, autism, ADHD, PTSD, TB, MRSA, AIDs, MS, diabetes and cancer etc. are indicators that the autoimmune disease in question is “gaining ground” on the ability of humans to immunologically protect themselves in this temporal cycle. It is a good possibility! The microorganism is ubiquitous to all vertebrate society, so it is a bilateral zooinosis, so to speak, and there is a constant reservoir of organisms in vertebrate life around the world.

Various environmental conditions make the often-subtle infections more common. Living in economically poor societies, existing in crowded conditions, living in more soiled environments, and existing in cooler, damper environments all cause the disease to be more common. Within the military environment, especially overseas, two of the three factors, mentioned above, are prominent: living in crowded environments and living in economically poor societies. I am quite sure that the Vietnam Syndrome and the Iraq War Syndrome are manifestations of the underlying infectious and autoimmune disease of which I am writing.

It is common for those with the rheumatoid diseases, cancer and arteriosclerosis (and aneurysms) to have neuropathies. It is common for patients with AIDS to have neuropathies, rheumatoid diseases, cancer, psychological abnormalities including homosexuality, and other infections, as you know. Typical texts like “Harrison's Principles of Internal Medicine” mentions the associated problems, mentioned above, in AIDS patients, but also that they have rheumatological disease paradoxically! The rheumatoid diseases are known to be paraneoplastic, especially, dermatomyositis and Wegener's granulomatosis, but in my patients through the years, all patients that developed cancer had, at least, mild rheumatoid arthritis. Guillain-Barre' syndrome is a paraneoplastic disease also, and it is basically a wide-spread neuropathy, something like acute MS, which it surely is. Those diseases are thought to be paraneoplastic, because the underlying inflammatory, autoimmune disease causes the syndrome in question, but also the cancer that somewhat frequently appears with them.

Organismen i spørsmålet er endemisk i samfunnet. Det er allestedsnærværende i naturen og jeg fant informasjonen i russisk litteratur at alle husdyr ha infeksjoner av og er bærere av denne organismen på forskjellige tider i livet. Jeg tror alle virveldyr, generelt, lider infeksjoner fra og er bærere av, mikroorganismen i spørsmålet, mange ganger i livet, også.

En sentral konsept er: fra den første infeksjon av mikroorganismen i tvil om at en person har i livet sitt, de utvikle den inflammatoriske autoimmune sykdommen på noen nivå. Andre infeksjoner føre til en økning i den subtile, eller ikke så subtil, autoimmun respons! Jeg tror genetikk av mikroorganismen er variert nok til at organismen "morph" med visse mikroorganismer miljøer, slik som å kunne eksistere i forskjellige mikro-anatomiske nisjer. Den forrige Ideen er en hypotese, men det ville være lett for en mikrobiolog for å sjekke.

Som en side-note vil jeg nevne at jeg møtte en kvinne som bodde på Vancouver Island, British Columbia. Hun utviklet livmorhalskreft i løpet av hennes slutten av tjueårene og hadde kirurgisk behandling tilpasset den tilstanden. Så etterpå hadde hun brystkreft i hennes midten av førtiårene. Hun hadde bilaterale mastectomies og rekonstruktiv kirurgi. Mens du snakker med henne jeg fikk vite at hennes far hadde vært en kanadisk Forces tannlege. Det er ingen steder mer sannsynlig at kontrakten mikrobiell sykdom, enn å jobbe på folks tenner, daglig! Hennes sønn hadde Aspergers syndrom, en autistisk spektrum mental tilstand. Hennes far døde av hjertesvikt som følge av idiopatisk kardiomyopati, og en søster hadde Nevrofibromatose, alt forårsaket, tror jeg, med denne underliggende autoimmun sykdom som i seg selv forårsaket av mikroorganismen i spørsmålet. Den tidligere tilstand, kardiomyopati, regnes i teksten, "autoimmune sykdommer", tidligere sitert, for å være av en autoimmun natur. Sistnevnte sykdom, Nevrofibromatose (Von Recklinghausens syndrom), er en sykdom som jeg hadde bare én pasient, men jeg har tilknytning til tre andre, og jeg tror dette underliggende, provoserende, autoimmun sykdom er knyttet til patogenesen sin.

Jeg hadde en god venn, og om lag ti år siden han utviklet ALS og døde. Hans mor døde av MS. Hans kone hadde lumbal kirurgi for en påstått herniated plate som ikke ble helbredet ved kirurgi. Realiteten er at hun hadde sakral plexus nevritt fra samme underliggende, kronisk, inflammatorisk, autoimmune sykdommen hennes ektemann hadde. Min venn hadde visse psykiske egenskaper knyttet til autoimmune sykdommer og, selvfølgelig, han omsider presentert med nevrologiske symptomer forenlig med ALS. Hans sønn hadde kroniske anfall. Disse nevrologiske syndromer, innen familier, igjen, er lik de jeg bemerket gjennom årene, i min praksis i medisin i Washington State.

Washington State, forresten, har, tror jeg, har den åttende høyeste angrepet rate for kreft vurderer alle statene i USA. Det er velkjent at MS angrepet er høy i nordlige tier land, og jeg vet det er fordi infeksjoner av mikroorganismen aktuelle er mer vanlig i kjøligere, mer-fuktige steder. MS er vanlig i min praksis område. Det er en semi-bygdevei like nord for Toledo, Wa., En by med bare 690 innbyggere, og tre mennesker som bor opprinnelsesbeviset har MS, og de lever innenfor en halv kilometer fra hverandre. To andre personer som utviklet MS vokste opp i nærheten! Det må være en logisk grunn! Årsaken er ingen tvil om at de alle gikk på samme skole og mikroorganismer i spørsmålet ble spredd blant de barna som de gikk på skole!

Jeg nevnte smittsomme sykdommer som AIDS, MRSA og tuberkulose, fordi de er vanligvis ikke svært smittsomt, men med en relativt høy grad av inflammatorisk, autoimmun sykdom den beskyttende immunforsvaret er redusert, over tid, tillater disse relativt mild patogener å bli mer invasive og patologisk. Det finnes andre bakterier, virus, parasitter og sopp, som kan forårsake infeksjoner i de som er immunologisk deprimert. For eksempel, kanskje malaria, lepra, sovesyke og mange virussykdommer er medlemmer av samme delmengden. I områder som Sub-Sahara Afrika, et sted der befolkningen opplever faget smittsom sykdom og autoimmun reaksjon på en høy frekvens, er det sannsynlig at befolkningen som helhet, sannsynligvis har en alvorlig svekkelse med deres immunforsvar slik at de enkelt kontrakt sykdommer, nevnt.

Also, even though those with AIDS have immune deficiency due to the pathological action of the AIDS virus itself, the patients probably had immunological deficiency from the autoimmune disease in question and it permitted the AIDS virus to invade initially. It may be that some subspecies of Staphylococcus aureus are highly resistant to antibiotics, including methacillin, since it has had the opportunity to evolve genes contributing to antibiotic resistance in those humans, who have had immune system degradation previously by the autoimmune disease in question. This is another hypothesis within my theory, but I have reasons for it, since many of my patients developed unusual, aggressive infections especially if they had the autoimmune disease seriously.

Another area of medicine and human behavior I have touched on, above, is the common development of psychological disease states and these are usually described as autism, ADHD, PTSD, schizophrenia, depression, manic-depressive illness, chronic anxiety, explosive personality, the driven, Type A personality, Alzheimer's disease, and Parkinson's disease (the last two are probable). Other, more subtle psychological and personality abnormalities are also caused by this underlying autoimmune disease process, such as learning deficits. In addition, chronic fatigue syndrome and perhaps anorexia nervosa are caused by this disease process. All the above conditions exist as central nervous system neuropathies, that is, central nervous manifestations of a systemic autoimmune, inflammatory disease process. The inflammatory autoimmune disease disturbs the blood-brain barrier enabling autoimmune factors and other serum factors to enter the brain tissues and cause neurological tissue damage. The time in life, the severity, the chronicity, the subtypes of microorganism, the frequency of the infection, all which affect the autoimmune response, and the ability of a given person immune system to combat the infectious disease and autoimmune response, causes the variation in clinical psychological manifestations noted in the above conditions.

To understand the systemic autoimmune inflammatory disease process, one has to mentally exit from the a priori thought picture, that we, physicians, medical scientists and lay-persons, have been conditioned to think about disease development. For sixty years, at least, we have been educated to think according to the “specialist divisions of medicine”. The human body is not naturally segregated, conveniently, into systems except as a tool to understand anatomy in medical training as one is learning that subject. One must think as the body reacts: in a systemic fashion. A person must realize that there is an infectious disease, which can be acute and important or so mild and chronic that the patient may feel normal, but both cause an inflammatory, autoimmune attack, usually subtle, but which can be acute and severe. Even the carrier state stimulates an immune and therefore an autoimmune response. One has to realize that the autoimmune attack ebbs and flows over time within the individual depending on the microbial environment in which one lives and depending on the individual immune response to the infectious process and the autoimmune process.

One has to realize that each tissue and therefore organ will respond to the pathological, inflammatory, autoimmune attack differently. The heart develops arteriosclerosis, cardiac arrhythmias, cardiomyopathy and pericarditis; the skin develops rosacea, erythroderma, spider nevi, nevi, seborrheic keratosis (age marks) and dermatitis and graying of the hair. The gastrointestinal system organs develop esophagitis, ulcers, polyps, diverticula, primary sclerosing cholangitis, ulcerative colitis, Crohn's disease, autoimmune hepatitis , cholecystitis, and pancreatitis. The brain develops functional abnormalities such as autism, ADHD, PTSD, schizophrenia, disassociative phenomenon, manic-depression, depression, learning deficits, personality disorders, Alzheimer's disease and Parkinson's disease. Many humans are in jails and prisons because of the behavioral abnormalities they develop from autoimmune cerebritis. Patients can develop learning deficits and one of the losses can be moral learning. The subtle mental change that takes place during puberty can be altered and some individuals experience a decreased transition to the heterosexual orientation and stay non-differentiated in that respect, but they develop normal somatic secondary sexual characteristics, thus the homosexual individual is developed. A combination of the explosive personality, deviant sexual orientation, and immoral thinking patterns produce, I think, the criminal personality. We are conditioned to think that people are just bad, but I think they suffer from an organic, inflammatory, autoimmune cerebritis, which causes their abnormal behavioral tendencies.

The brain malfunctions in various ways depending on the pattern of infectious disease and therefore the autoimmune response, and how the autoimmune attack has developed. Most children with autism are treated by pediatricians or pediatric neurologists. Patients who have Parkinson's disease are seen by neurologists, internists, or psychiatrists, so the similarities are not noticed in the current specialty, clinical arrangement. If you think about it, a child with high-grade autism acts like a miniature individual with high-grade Parkinson's disease. I have had both types of patients in my clinic and I was surprised how familiar they were. The child with autism had developmental hemophilia due to the autoimmune disease in question also. The child's mother had lupus erythematosis and fibromyalgia with sciatic neuritis and brachial plexus neuritis, all of an autoimmune cause. The child's mother was, no doubt, the “microbial carrier” that led to her child developing autoimmune disease manifested by severe autism (autoimmune cerebritis) at about thee years old.

The vascular tree develops arteriosclerosis, aneurysms, phlebitis, thrombophlebitis, thromboembolism and lymphedema. The autoimmune attack on the gonads disturbs meiosis and causes genetic changes that lead to genetic birth defects. A similar inflammatory autoimmune attack on somatic cells causes somatic genetic aberrations, which can lead to clinical cancer development. Autoantibodies can pass through the placenta and cause a great variety of developmental birth defects. One has to realize that phenomenon that appear in complex systems appear in a somewhat random fashion!

Those with autoimmune inflammatory disease experience difficulty healing. The slow- union or non-union of fractures, the slow healing of surgical sites with the development of keloids, incisional hernias, and adhesions are common in such a group. At times women, if they experience a high-grade autoimmune condition, can pass autoantibodies through the placenta and cause difficulty in embryological tissue-plane-merging and so cleft palate and spina bifida, among other developmental birth defects, can develop. This infectious disease and the autoimmunological response is much more common in “third world countries” such as Vietnam, and of course there are many missions to that country to repair cleft palate and developmental abnormalities to the heart, for instance.

Patients and clinicians notice abnormalities in the organs of special senses most commonly. The eyes develop cataracts, presbyopia, macular degeneration, glaucoma, retinal detachment, iritis, uveitis, penguecula development, diplopia, scleritis and choroiditis, etc. The hearing sense develops tinnitis, and decreased function. The vestibular nerve can malfunction and the individual may develop vertigo. The facial nerve abnormalities lead to Bell's palsey. Autoimmune trigeminal neuritis causes migraine headaches. Rheumatoid tempo-mandibular arthritis causes TMJ headaches and it is not unusual for both types of headaches to exist concomitantly since they are both caused by the same underlying autoimmune vasculitic condition.

Most people have heard about the risk factors of coronary artery disease: a positive family history of CAD, type A personality, high cholesterol, diabetes, hypertension, transverse ear lobe folds (an idea of about 15 years ago), and I will ad my own: neurological back pain: sciatica. The same risk factors fit for those with arteriolar aneurysms and peripheral vascular disease. The reality is that all the markers or risk factors are simply concomitant phenomena caused by the inflammatory, autoimmune disease about which I am writing. The positive family history is not due to genetics, it is because individuals within families are more likely to contract the infection in question, and therefore develop the autoimmune disease, more frequently.

I have been to Vietnam, Taiwan, and Mexico recently for extended periods and I know the underlying infectious disease and the autoimmune response is more severe and endemic in those more economically undeveloped locales than here, in America, and in Western Europe. The microorganism has been brought here, including various strains that are more pathological, and such importation has caused an increase in the commonality and severity of the autoimmune disease process, that is systemic in nature, and therefore the above conditions are more prevalent than, let us say, 30 years ago. There are other influences that have caused the infection and autoimmune response to be more prevalent, also.

Being a general practitioner, and having worked in the US Navy in the USA and overseas, or in small-town clinics all my professional life, so I have not published in academic journals. I did, however speak at the Second World Conference on Immune-Mediated Diseases in Moscow, last September. I was a substitute speaker, for I took the place of a Russian scientist who had had a heart attack, on an afternoon of one of the last days. I think most of the “listeners” were Russian pediatric allergists, since they sponsored the meeting. Most of the international “academics” had left since they were there, basically, to give their own talks. I am not sure if many of the Russians understood my “rapid English” since I only had twenty-five minutes to speak. Since this is a systemic disease process, it is naturally complex. For that reason I have written a book so that I can explain many more of the mechanisms of disease production in the various tissues and organs and how the underlying, systemic, inflammatory autoimmune disease plays the key role.

Most medical and scientific research, nowadays, is conducted via microscopic or submicroscopic means. The articles in the 2000, or so, medical journals printed in the world can attest to that fact. Most research findings do not really affect the practical advancement of medical science wherein the treatment of diseases is improved. My research was of a macroscopic, clinical and epidemiological nature. I used induction to reason out and see the relationships between the biological and clinical observations I have made being a physician. I have seen 230,000 patient interfaces and that comprises a great number of observations. I had a great setting, being an independent clinic owner, in a poor area, for nearly a quarter century. Poor people are sicker people, in general, and being a general practitioner, and treating all diseases, I “had a chance” to put the puzzle together.

Another advantage I had, perhaps, is that I am a former US Marine officer. I was a Phantom II pilot with 146 combat missions in the Vietnam War. While flying a high performance jet, I had to learn to integrate a great number of factors, simultaneously, and perhaps I became something of a systems analyst, at 500kts with people shooting at me! Marines have a saying, “the difficult we do immediately, and the impossible just takes a little longer.” Humorous, it is, but Tarawa, Iwo Jima, and other nasty places were dealt with successfully through perseverance more than intelligence. My investigation took a great amount of perseverance, an experienced knowledge of many disease entities, being located in one clinic for a long period, and I saw, medically, males and females of all ages and for all diseases. I had the perseverance and the sense of duty to my patients to work 12-14 hours a day for two and one-half years and eventually I “figured out” the puzzle, the enigma!

Det neste trinnet i å gi riktig forsikring om at min teori er riktig, er at jeg ville trenge for å få kontakt med en undersøkende gruppe som har en kobling til et stort sykehus / klinikk system og koordinere serologi og inflammatorisk markør testing av årskull av pasienter. Pasienter med: brystkreft, tykktarmskreft, kreft i hjernen, leukemi, diabetes, Cushings syndrom, Addisons sykdom, Polycystisk ovariesyndrom sykdom, Parkinsons sykdom, Alzheimers sykdom, åreforkalkning, hjerneslag, hypotyreose, ulcerøs kolitt, kroniske smerter fra fibromyalgi og nevropatier, øsofagitt, magesår, AIDS, tuberkulose, MRSA, de revmatiske sykdommer, Crohns sykdom, ventrikkelsår osv.

Kanskje femti av hver type pasient kunne inkluderes i den serologiske undersøkelsen. Phlebotomies kan organiseres gjennom sykehuset og klinikken via en kontraktsmessig avtale og hver pasient eller vaktmesteren kunne signere en tillatelse slip for testen. Slik testing er ganske enkelt å organisere, tenke jeg. Hvis serologiske resultatene er positive, som de var i min egen klinikk, er at hvis noe sånt 60% av pasientene har forhøyet serologi, er teorien bevist. Antistoffnivåer slipp, over tid, dersom en pasient ikke har en infeksjon i den mellomliggende perioden, men immunforsvaret fortsatt er i drift på en patologisk måte, selv om antistoffer, som også autoantistoffer, er på et lavere nivå. Pasienten er fortsatt immunologisk primet å svare aggressivt til gjentatte infeksjoner i fremtiden. Dette er hva som forårsaker forverring av revmatoid artritt, for eksempel, og hvorfor ryggsmerter forverrer: fordi den autoimmune sykdommen bedres, til en viss grad, hvis en person ikke har en infeksjon, av organismen i spørsmålet, for en viss periode, og deretter dersom en ny infeksjon finner sted den inflammatoriske autoimmune sykdommen blir verre.

En person kan velge å gjøre ytterligere testing på et større antall og på flere ulike kohorter av pasienter, i tillegg til å gjøre beviset mer fast. Når teorien er bevist, kan forskningen begynne i et forsøk på å lage autoantigen, autoantistoff og target-vev betablokkere. Den første og siste er trolig like. En gruppe av medikamenter fra eksisterende Pharmacopeia kan utvikles til å hemme autoimmun reaksjon. Jeg hadde mange, mange pasienter på et utvalg av medisiner som hjalp uten spørsmål. En vaksine kan utvikles!

Mange mennesker dør tidlig i livet fra kreft, hjertesykdom, og aneurisme formasjon, fordi de, mer eller mindre, alder tidlig. De enkelte organer som utvikler kliniske abnormiteter fra den underliggende, provoserende, autoimmun sykdom stiller dem med litt tilfeldigheter, som ville være naturlig i et komplekst system. Det er ganske vanlig, men for en person å ha ryggsmerter, en eksplosiv eller drevet personlighet (type A), noe leddgikt i kneet, og opplever en artroskopisk kirurgi. Senere kan leddgikt i hendene vises, og deretter alder mark seboreisk keratose) utvikler. Den enkelte kan ha hatt Nevi og trenger å se for malignt melanom. Etter noen år har de et hjerteinfarkt eller angina og har en stent emplaced. Kanskje senere, utvikler de atrieflimmer, og deretter ti år senere de får kreft. Den tidsmessige utseende av sykdommene nevnt ovenfor, som er virkelig target-orgel manifestasjoner av en underliggende autoimmun sykdom, og er i sekvensen jeg bemerket i de medlemmene av familiene i mitt område, blant andre. Et fenomen som finner sted, at vi bare tar for gitt, er at når vi blir eldre vi blir rødmusset ansikt og gråning av håret. Begge er manifestasjoner av den subtile, autoimmune, inflammatorisk sykdom som vi alle har! De universelle fysiske endringer som alle mennesker opplever, ofte kalt aldring, er, sikkert, for det meste, de fysiske manifestasjoner av denne underliggende smittsomme / autoimmun, inflammatorisk prosess.

Som alle break-throughs i vitenskap, var jeg mottakeren av millioner av biter av kunnskap fra mine mentorer gjennom årene, og deretter fra mine egne kliniske erfaringer. Alle bitene av "bestått-on" kunnskap (jeg høres ut som Bill Gates = biter av kunnskap) og personlige medisinske observasjoner førte til en generalisering. Som mange nye innsikter er det enkelt når det er forstått, slik: E = MC sq Selv visualisering av sykdommen mentalt, er noe beslektet med Einsteins heuristiske tanker som førte til spesielle relativitetsteorien.

Einstein skrev, jo enklere en teori, og jo flere observasjoner den forklarer, desto mer sannsynlig er det å være korrekt (omskrevet). My theory is simple and it explains most of the puzzling observations I have had in medicine for over thirty years, and serological testing and the taking of medical histories proved it is correct.

James W. Goding, MD, Ph.D., Monash University, Australia, wrote in the epilogue of “The Autoimmune Diseases”, “Would the Real Autoantigen Please Stand Up!” He was referring to the concept that there was probably one autoantigen or group of antigens from one source that caused the autoimmune diseases listed in that long text. I have found it, I am very sure.

I know that many would think that I, being an sixty-eight year old osteopathic, general practitioner, may be one of the most unlikely medical professionals to develop a major insight in medicine! I was, however, the one independently seeing patients of both sexes, of all ages, for all diseases, in one community, for a long period, an unusual situation in medicine nowadays in the period of procedural, specialty-dominated medicine. In my setting, I alone had the responsibility to determine what was medically causing disease processes within my patients. I was an independent physician and worked in an economically poor area. I had the independence of thought, to determine what I have managed.

Also, one must realize that John Snow, a general physician in London, did an epidemiological study and determined that cholera was spread by water supplies before the microbiological theory was well developed. In addition, one must remember that Louis Pasteur and Claude Bernard were not connected to a research institute. One could consider that Walter Reed and his physician associates, Dr.Jesse Lazear and Dr. James Carroll, and even Dr. Carlos Findlay, the Cuban physician who advanced the theory that the mosquito transmitted yellow fever twenty years before Dr. Reed's research project, who together proved that Yellow Fever was spread via the mosquito, were simply general practice physicians. To tell you the truth, the division of medicine into specialties has harmed the discovery of disease processes because specialists, by concept and training, develop a constricted view of medical science and t times never see sick patients. Since this autoimmune disease presents primarily as a vasculitis, and since there are no vasculogists (a new word), no one would ever determine that people have a wide-spread, inflammatory, autoimmune, vasculitic disease!

To give you a better idea of how simple it is, just look in “Harrison's Principles of Internal Medicine, 16th Edition”, within the section that discusses rheumatoid arthritis. The information provided indicates that there is no known cause for rheumatoid arthritis (RA), and that it is a systemic, autoimmune disease that features arthritis, neuropathy, and vasculitis, and that it can cause organ infarction, even a myocardial infarction. Earlier editions (the 13th edition, for instance) also indicated that a feverish disease could cause an exacerbation of RA. Since myocardial infarctions are caused by arteriosclerosis, as a general disease process, other clinical manifestations are peripheral vascular disease, stroke, arterial aneurysms and venous abnormalities such as venous thrombosis. I just had to learn what caused the feverish disease that triggered exacerbations of RA, and put the puzzle together. Thereafter, I just had to add on the fact that most people who develop cancer have, at least, one of the rheumatological diseases, for instance rheumatoid arthritis, at least subtlety, and so there is no doubt that the rheumatoid diseases and cancer are caused by the same underlying autoimmune disease process.

Even Galen, the famous Greek physician, scientist and philosopher, in 200 AD, coined the word “rheumatism” because the word-root rheum means phlegm. He knew that respiratory infections that frequently caused expectoration (coughing up phlegm) and coryza (phlegm from the nose), led to a miserable, chronic condition in his patients. He termed it “rheumatismos” or in English, “rheumatism”. Yes, arteriosclerosis, cancer, the endocrine diseases, the rheumatoid diseases, peripheral and central neuropathies and many more conditions are part of the rheumatism concept. They are all end-organ manifestations of the systemic, autoimmune, inflammatory disease of rheumatism!

Philology, the science of language, has, over hundreds of years, incorporated a great amount of wisdom within itself . In the Webster's New Twentieth Century Dictionary, 1976, it mentions under the word rheumatism: “any of various painful conditions of the joints and muscles; especial y, a disease believed to be caused by a microorganism and characterized by inflammation and pain in the joints.”

The “nut” of my theory has been known for thousands of years, but now with added, more recent knowledge from bacteriology, immunology, and the autoimmune concept, and by thinking systemically, as I saw my patients, especially during the clinical, epidemiological investigation I have mentioned, the nature of the disease process let itself be known.

I have presented the case for a disease that is so common, since it is caused by a microorganism ubiquitous to the society of vertebrates, and the autoimmune, inflammatory affects so universal, that we all have it. You, me, my kids, my ex-wife, my neighbors (I know the family: Dad has Charcot-Marie-Toothe syndrome (high arches and neuropathy of the legs), a cardiac stent and then a CABG and between the two was in the hospital for 8 days for “pneumonia with complications”, which was really a disease episode from the organism in question. Both his sons have the disease quite meaningfully as they have chronic pain and peripheral neuropathies. All of us humans in the world have the disease, because the organism is so ubiquitous. Some people and families have it worse, naturally. Those individuals and families often do not function well in life.

Since I have finished a book of approximately 200 pages concerning this disease process I could naturally write on and on. I will not, however, but I will say this: Over the last fifteen years there has been a great increase in the number of cancer, fibromyalgia, chronic pain, and autistic patients and the appearance of many infections such as TB, syphlis, MRSA, etc., in the American scene, of which I am most familiar. There has also been special manifestations of diseases, psychological and physical, in military men returning from overseas duty, especially from Vietnam and the Middle East. The reason this is true, I believe, is that the pathogens that cause the diseases are more common in poor societies and we, by our war activities, make the disease more manifest in the civilians in the war zone and within our own troops. In addition, infections by the microorganism and therefore the autoimmune response has become more meaningful in American society due to the immigration of ten million people from Mexico and Southeast Asia. Frequent international air travel has introduced microorganisms, or more pathological strains of microorganisms, into our country also.

Hopefully, you have found this letter a little entertaining and interesting. I think I am correct concerning the principles of my theory. I have interviewed, medically, over two hundred and thirty thousand patients during 30 year practice period. I was a physician in medicine, with a wide interest and the responsibility for treating my patients with all medical problems. I practiced in an economically poor area, with quite a few Mexican immigrants, so the markers of disease appeared more overtly than in a more affluent community. I have proved my theory via serological testing. I spent nine months visiting nine countries to determine that this disease process is world-wide. I am presenting a new generalization in medicine, a unifying theory of most or many of the idiopathic disease entities that have filled medical books for decades. The guiding theory, and the pathological and immunological principles that support it, will enable medical scientists to “focus” on the cause of diseases (really target-organ manifestations of an underlying autoimmune disease) and not just try this or that random molecule via a clinical trial, to see if it works on this or that malady.

I have had trouble relaying my information to a research organization because I am semi-retired, sixty-eight, an osteopathic general practitioner, and not an allopathic physician, because I have never worked in a research organization and I have not had any research published. Really, I have found that most individuals, who are in investigative organizations, are typically comfortable dealing with professionals similar to themselves and are not overtly open to new ideas from a person not currently in the structured research industry. Naturally, I can understand such reluctance. The reality is, however, millions of researchers world-wide are usually working with a similar mental-set, using similar techniques and intellectual approaches, and the results of research leaves something to be desired since there have been no “major” breakthroughs detailing the cause of a major diseases in decades!

I am interested in collaborating with a research organization that can help further prove my theory and develop the pharmaceuticals needed to control the disease process. I think that the pharmaceuticals will surely be the most helpful to members of human society, and therefore the most profitable, in the history of medical treatment!

I have been a solo practitioner in a small town most of my medical career and have not associated with other physicians much. I have, however, an old professional and personal friend, Albert Mark, who I have known since I was 16, since I worked for him when he was an active pharmacist. His phone is 1-425-454-0300. His e-mail is: AMMark914@gmail.com . You are free to talk to him concerning me, my background, and my ethics. In addition, I still communicate with my anatomy professor from medical school, Jack Julyan, PhD. His e-mail is carol@julyan.org . He knew me quite well and he was a great teacher.
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Thanks for reading this letter. If you have any interest, please contact me at: ecnal-c@hotmail.com , or 360-864-4371. My address is PMB 227; 120 State Ave. NE, Olympia, Wa., 98501

Yours Truly,

Lance W. Christiansen, DO

Yours,

Lance Christiansen, DO.