Komercionalizáciu biotechnológie v Číne

Dear Dr. Gingras,

I have been a physician for a long period. I have conducted an investigation and have learned the cause of many idiopathic diseases including peripheral neuropathies, central neuropathies, arteriosclerosis, cancer, and others. I realize my claim sounds pompous, but like most things, it is simple once the principles are “figured out”.

I am looking for a “place to further prove my theory” and then develop and manufacture the autoantibody blocking agents to control the underlying autoimmune disease that causes the target-organ manifestations, typically thought to be diseases.

I determined the nature of the microorganism that triggers the disease process, essentially.

If you have interest in learning more contact me on my e-mail site.

I have been in the USMC, in Vietnam as a pilot and also worked in Japan for a year. I have been in Taiwan, but not mainland China. I would like to work there though.

I owned three clinics at one time, but now I am semi-retired and doing academic research to reinforce the clinical investigation I did over a three year period. I will attach a paper if I can.

A Unifying Theory of Diseases,

Autoimmune-Disease and Target-Organ Manifestations

I am a general practitioner in medicine, and I have, I am sure, developed a meaningful insight into the cause of many, heretofore, idiopathic diseases. Idiopathic diseases have been described with increasing frequency during the last sixty years after most of the infectious diseases were understood and controlled with antibiotics by the first half of the 1900's. Now, medical texts have become filled with the descriptions of thousands of idiopathic diseases, those diseases with no known cause, and since their causes are not known the treatments for them are disease altering not disease curing.

Surprisingly, most idiopathic diseases are target-organ manifestation of a systemic, inflammatory, autoimmune-disease process. The autoimmune-disease is caused by an inflammatory, autoimmune condition, which is itself caused or triggered by an infection by a microorganism. It is a microorganism that is quite common and it is ubiquitous to populations of vertebrates, which includes domestic animals and humans. With that in mind, a person can consider the disease a bilateral zooinosis.

Niektoré ciele-orgánové prejavy autoimunitného ochorenia procesu sú obyčajne známy dermatologicky. Lekárske pozorovatelia nemajú zvyčajne myslia, že dermatologické funkcie, ako névy, stenčenie kože a vrások, seboroická keratózy, angiomy, seboroická dermatitída, ekzém, poliosis, šedivenie srsti apod sú nevyhnutne patologické v prírode. Často sú považované za súčasť procesu starnutia. Ak však človek vyvíja ischemickej choroby srdca, rakovina, glaukóm, žlčové kamene a na reumatoidnej ochorenia alebo cukrovka, s pribúdajúcim vekom, a problém môže byť umiestnená do určitého orgánu o procesne vyškolený špecialista, je myšlienka, že špecifická ochorenia, kde je to naozaj cielene orgán prejavom systémové a autoimunitné ochorenia sprostredkované procesu.

Ja, pracuje ako praktický lekár, zistil, že väčšina idiopatickej ochorenia sú cielene orgánové prejavy systémové autoimunitné ochorenie, zápalovým procesom. Tým, že má iný vzdelávací zázemie (časť z toho v leteckej analytické systémy) a klinický prístup k liekom, a tým, že berie muža a ženy všetkých vekových kategórií, pre všetky choroby, mohol som mať poznatky, ktoré viedli k novej filozofie choroby vývoj, ktorý vysvetľuje príčiny väčšiny chorôb idiopatickou vrátane mnohých dermatologických podmienok, gastrointestinálne ochorenia, neurologických ochorenia, rakovina, kôrnatenie ciev a na reumatických chorôb a endokrinných chorôb, ktoré dohromady, môže byť koncipovaná tak, aby veľká časť procesu starnutia .

Videl som viac ako 230.000 pacientov návštevy, vrátane 1000 navštívi doma v chudobnej, čiastočne vidiecke komunity protokolovanie so žiadnou moderného priemyslu. Po dlhej dobe som si všimol určité kombinácie ochorení v rámci členov rodiny až pre štyri generácie. Vzhľadom k tomuto javu, a vzhľadom k početnosti MS a periférnych neuropatiou v mojej obci, rozhodol som sa urobiť klinické a epidemiologické vyšetrovanie. Informácie na týchto stránkach vysvetľuje moje hľadanie, niektorí z mojich nálezov a niektoré veci, ktoré sú vhodné v budúcnosti. Som sa zmienil o identifikáciu mikroorganizmov, ktorá spúšťa autoimunitné reakciu, pretože táto informácia je môj vlastný znalosti v tejto dobe. Vďaka za prečítanie tohto dlhý list / papier, vopred.

Bol som vojenské a civilné lekár pre tridsať jedna rokov, klinický lekársky teoretik v posledných troch rokoch svojho adaptačného obdobia, a akademický výskumník v posledných troch rokoch.

Niektoré vedy zažili kvantovej prelomy v minulosti, napríklad fyzika (slovná hračka určená), fyzikálnej chémie, astronómie a kozmológie, laser veda, imunológie a možno dokonca aj poznatky, ktoré viedli k tranzistora a digitálny počítač-kód pojmov, ktoré následne viedli na "počítačovej revolúcie". Medicína, ako vedeckého snaženia, má skúsenosti z mnohých vedecké objavy v minulosti, ale žiadny z teoretického charakteru, ktorá popisuje príčiny chorôb od konca 1700 alebo možno čoskoro 1800, kedy hypotéza a teórie sa vyvíjala, že mikroorganizmy môžu spôsobiť chorobu. Tento objav viedol k poznaniu, čo viedlo k vývoju antibiotík v 1930 a 1940. Tento objav bol pravdepodobne posledný veľký prielom v medicíne!

Ako viete, diagnostické a terapeutické snahy boli vyvinuté v priebehu posledných šesťdesiatich rokov, prostredníctvom pôžičiek od iných high-tech oblastiach, ako je elektronika, laser, ultrazvuk vedy, biochémia a výpočtovej techniky, ale nie s pochopením určených priamo z teoretickej medicíny, ktoré by mohli poskytnúť priamy prístup k charakteru vývoja choroby a tým aj jeho liečba. Existuje veľa high-tech zariadenia, ktoré vám pomôžu minimalizovať vplyv choroby na určitom orgáne alebo pomôcť tomu, aby viac definitívnu diagnózu, ale napriek tomu znova, ovplyvňuje ochorenia sú zmenené a nie sú vedecky priblížil tým, že najprv určenie ich príčiny .

Vývoj vedy o genetike, kmeňových buniek a ďalších konceptov, nových koncepcií v biológii, splodila myšlienku, že použitie týchto zmysluplné a často zložité objavy budú viesť k novej liečbe "tej či onej chorobe", aj keď príčina choroby nie je známa. Vždy sa zdá byť nový "príčina célèbre '" v medicíne.

Počas posledných troch rokov mojej praxe lehoty, som vykonal epidemiologické, klinické vyšetrenie, a potom som vykonala dvojročnú epidemiologickú, akademické a historické lekárskeho výskumného projektu, údaje, z ktorých prevažne podporuje moju teóriu. V priebehu deviatich mesiacov som cestoval do deviatich krajín a navštívili kliník a nemocníc a hovoril s ľuďmi a skúmal som stretol na rôznych miestach. Som sa uistil som si, že mikrobiálne infekcie a autoimunitné ochorenie, ktoré sa spustí, čo spôsobuje mnoho typov koncových orgánov prejavy, vrátane rakoviny, kôrnatenie ciev, poškodenie u novorodencov a reumatických chorôb, napríklad, je ten, ktorý existuje na celom svete, ako som sa domnieval, ale samozrejme je to vážnejšie, v niektorých miestach na svete ako ostatní.

Časť mojej myslenie procesov zapojiť poznatky, ku ktorým došlo v priebehu dlhej histórie medicíny a ako lekárske pojmy ochorení vzniku a liečby pre nich sa vyvinuli v priebehu času. Ako dobre viete, infekčné ochorenie spôsobil veľké zdravotné problémy ľudstva na nespočetných storočí, ale vznik mikrobiológie a potom objav hygienických postupov a antibiotík, v strednej-1800 do polovice roku 1900, zníženie frekvencie a význam infekčných ochorení . Pred období bolo spomenuté, aj choroby spôsobené mikroorganizmami boli idiopatická v prírode.

Od roku 1930, kedy boli antibiotiká najprv použitý klinicky, lekárske texty majú "stanú dominuje" v popise podmienok, ktoré sú naozaj idiopatickej ochorení: rakovina, periférna neuropatia, kôrnatenie ciev, rôzne reumatických chorôb, rôzne endokrinné ochorenia, osteoporóza, Alzheimerova choroba, Parkinsonova choroba, autizmus, ADHD, PTSD, fibromyalgia a mnoho ďalších ochorení tohto typu. Tieto a zrejme aj 2000 ďalšie idiopatickej ochorenia, sú roztriedené do lekárskych textov, ako sú "Zásady Harrisonových of Internal Medicine" a majú idiopatická, nie je tam žiadny známy dôvod k žiadnej z nich. Ak sú príčiny ochorenia nie sú známe, liečba je choroba zmenila, nie choroba vytvrdzovania, väčšinu času. Ako príklad tejto situácie, to je obyčajné odstrániť človeka žlčník kvôli zápalu, ale lekári zriedka sa spýtať, prečo žlčník bol rozpálený na prvom mieste! Pacienti s RS má markerov zápalu a kalcifikujúca vklady v centrálnom nervovom systéme, ale málokedy sa cvičiť neurológovia vážne pokúsi zistiť príčinu MS. Pacienti, ktorí majú rakovinu často majú neurologické bolesť, ale nikto nevie, prečo majú takú bolesť. U pacientov s AIDS často si reumatických podmienky, neuropatia, infekcie a rakovinu, ale málo je známe, prečo sa všetci existujú v tejto podskupine pacientov.

Rozhodol som sa na príčinu, jeden základný systémové príčiny, pre väčšinu z idiopatickej ochorení, a ja som poskytla opis svojho objavu nižšie. Dalo by sa povedať, že som objavil zjednocujúcej teórii idiopatickej ochorenie, to by bolo štatisticky nezvyčajné, a možno aj nemožné, aby existoval príčiny 2000 na 2000, alebo viac, ochorenia, ktoré vypĺňajú lekárske texty a s ktorými lekári a zdravotné vyšetrovatelia zaoberať, a sú na rozpakoch, každý deň.

I have been a general practice physician, both in the US Navy and in civilian life for nearly thirty years, but over the last six years, the best description of my activities is that I have worked as a theoretical, medical investigator. I was a jet pilot in the US Marine Corps, surprisingly, during my late twenties and early thirties, and then, since I originally had a degree in biology from Whitman College, I re-educated myself, by taking pre-medicine studies at the University of Washington and medical school at the Chicago College of Osteopathic Medicine, into a medical career. I practiced medicine in the Navy as a general medical officer/flight surgeon for five years during active duty and for five years as a reservist. For twenty-three years, thereafter, I was a small-town general practitioner. I always worked mentally in an effort to determine the causes of diseases, since I thought part of my duty as physician was to be a physician-investigator, as well as a being a diagnostician and treating physician.

I practiced in a semi-rural area of southwest Washington for over twenty years. I was a minor entrepreneur in medicine, for I developed three clinics and had three physician assistants helping me, but I personally saw most of the serious disease cases. I had a total enrollment of 7000 patients in my clinics, so I had a great volume of cases. I prided myself, after I had a number of years of experience, in treating all kinds of medical problems, for both males and females, of all ages, and not acting as a conveyor and send patients with meaningful diseases to specialists. Naturally, I referred patients to specialists for major surgery, internal scoping, imaging procedures, and ICU hospitalization since I practiced too far from a hospital to have such a practice. Such an experience in medicine is not common nowadays, since for fifty or more years medicine has been fragmented into artificial procedural, age-defined, organ oriented, system-related, disease related, and politically determined (family practice) specialties.

After seeing patients about twenty-five years I became somewhat introspective and realized that unless a patient had had a sprain, a laceration, or a fracture, or unless they had had an infection, nearly all the rest of the medical problems patients experienced were idiopathic (their causes are not known!). I realized that most treatments for idiopathic conditions had been developed by trial and error methods through the ages and the modern version of those efforts are the “clinical trials” of which you are, no doubt, highly familiar. There were situations wherein treating the above conditions, lacerations, fractures, sprains, and infections, were complicated. Slow healing of lacerations or surgical sites with the formation of incisional hernias, keloid development (large scars) and internal adhesions was common. The non-union or delayed-union of fractures, and sprains that caused chronic pain and swelling for months and sometimes years occurred somewhat frequently. At times, another “idiopathic disease name” was applied to explain patient's chronic pain: reflex sympathetic dystrophy or complex regional pain syndrome. No sure explanation for the cause of these syndromes had ever been given, accurately, in medical texts. Also, some infections are very difficult to treat even with existing antibiotics. There seemed to be something occult going on.

I worked in a logging and millwork area. I practiced in the small town of Toledo, Washington after I was a Navy physician, because the owner, who had had cardiac by-pass surgery wanted to retire and he “sold-out” to me for nothing down. I wanted to be a little isolated from “specialty medicine” because I did not want be, simply, a patient conveyor as I had been in the Navy. Well, I surely was not a conveyor and I was busy from the first day wherein I saw forty-six patients in a 12 hour shift. I worked nearly as steady for 21 years.

During the last five or six years I decided that neurological lumbar and cervical spinal pain was not, most of the time, caused by herniated spinal discs. It was rare that a patient improved, in a reasonable time, after lumbar or cervical spinal surgery! I treated many, many cases through the years. I decided to do an epidemiological, clinical investigation and try to find out the “true cause” for lumbar/buttock pain and neuropathy to the lower extremity and shoulder/neck pain and neuropathy to the upper extremity. Little did I know that I was involving myself in a many year project!

Over a two and one-half year period I attracted nearly 700 miserable, painful patients due to the severe peripheral neuropathy from which they suffered. One might consider them to be the “worst end of the bell-shaped curve”. Many of the patients, probably 40% had had spinal surgery and some patients suffered many, many surgeries. A woman patient had had four cervical surgeries and three lumbar surgeries performed by the same neurosurgeon! She was no better for her experiences. One man had had experienced eight lumbar surgeries and was not any better, either. It was common to have neurological problems in one lower and one upper extremity and at times in all four extremities. It was somewhat common for many members in a given family to have neurologically caused lower or upper back pain! It seemed that there was a systemic, somewhat contagious, occult, disease process going on, but somehow it localized in the nerves of the lumbar/buttock and the shoulder/cervical area.

During my clinical, epidemiological investigation, I used the techniques any physician could use. I did physical examinations and analytic, neurological physical examinations on my patients, but I used them intensely and repeatedly. I did personal and family medical histories intensely and repeatedly, also. I determined that the neurological problems were located deep in the buttock and shoulder, and not in the spine! I realized that pain is just one manifestation of inflammation (dolor, rubor, tumor, calor = from medicine 101), but I did not know what caused the inflammation.

I realized that these severely painful patients had similar dermatological abnormalities, and most had some kind of rheumatological malady. Rheumatoid arthritis, a history of juvenile rheumatoid arthritis, lupus erythematosis, scleraderma, Wegener's granulomatosis, Sjorgen's syndrome, mixed connective tissue disease, ankylosing spondylitis, and psoriasis, were all represented within the group. Naturally, mild rheumatoid arthritis was the most common. I realized that these diseases were all inflammatory and autoimmune in nature.

Many patients had an endocrine condition: hypothyroidism, hypoparathyroidism, Addison's disease, Cushing's syndrome, diabetes, pituitary, testicular and ovarian abnormalities were common. I realized that many of these diseases were also autoimmune in nature.

I did a search of medical literature and found the malady of autoimmune-mediated neuropathy. I realized that my patients had that problem: autoimmune-mediated, vasculitic neuropathy. The findings came from the Mayo Clinic Peripheral Nerve Group and Weill Medical College, which is a part of Cornell University.

Eventually, I learned how the autoimmune-mediated vasculitic neuropathy could be traumatically exacerbated, locally, and caused the somewhat-focused pain deep in the lumbosacral/ buttock area and the shoulder/cervical area. The pathology was not located in the lumbar or cervical spine, as I mentioned above, whereat surgical procedures are focused, but referred pain patterns made the pain radiate into those spinal areas. There are a few herniated discs I suppose, but not many. Surgery for them, however, is quite common! With a touch of sarcasm I will say that some time ago, well-meaning and reputable physicians bled patients for all kinds of problems, too.

Ako som si v práci na problém, som priťahovala viac a viac pacientov, a nakoniec som si uvedomil, že mnoho pacientov mal alebo rakovinu, keď som ich videl. Sedemdesiat, zo siedmich set, úbohý, bolestivé, pacienti, ktorí za mnou prišiel kvôli chronickej bolestivé neuropatia, alebo mal rakovinu. Priemerný vek bol asi 43, alebo tak, a všetky typy rakoviny boli zastúpené, ale samozrejme, najviac obyčajné druhy, ako je prsníka, krčka maternice, kože a hrubého čreva boli najčastejšie.

Niektorí pacienti mal mnoho prípadov rakoviny. Jedna žena, ktorá sa narodila v Manitobe, ktorého som sa pýtal, kde žil na ostrove Vancouver, mal štyri hlavné rakoviny a ja som poznamenal, že ona mala spinocelulárny karcinóm na tvári počas môjho prvého rozhovoru. Mala rakovinu krčka maternice, rakovina prsníka, hrubého čreva, a potom ďalšie rakoviny prsníka, a spinocelulárny karcinóm, cez tridsať rokov. Neexistuje spôsob, ako človek môže vytvoriť päť druhov rakoviny, ak tam bol chorobného procesu stimulácie patologické, somatické, genetické zmeny. Zistil som, že sa stala ťažko ochorel infekčnou chorobou v nemocnici, kde sa narodila a nebol čakal, že žije. Ona bola "označený" s autoimunitným ochorením takmer od narodenia a vyvinuli päť na sekundárne nádory, zápalovým autoimunitné útok počas svojho života!

Ďalšie žena, ktorá bola v chronickej bolesti u predtým diagnostikovanou fibromyalgia vyvinul sarkóm na jej anticubital fossa (predná strana lakťa), ako som ju videl. Ďalšie žena sa vyvíjal Pagetovej rakoviny prsníka a chronickej lymfatickej leukémie, v priebehu troch rokov. Pacient s Wegenerova granulomatóza vyvinula leukémiu a ona mala rakovinu krčka maternice skôr v jej živote. Muž s ankylozujúcou spondylitídou mal veľkú bazálny karcinóm na nose. Muž, ktorý mal chronickú ischiatického bolesti chrbta a tiež ulcerózna kolitída, ktorý je známy ako autoimúnne v prírode, rozvíjať rakoviny hrubého čreva.

Jeden muž, ktorý bol v jeho hornej sedemdesiatych rokoch bol môj pacient dvadsať jedna rokov. Bol chorý, keď bol malý chlapec a bol ťažko chorý, keď bol v americkom námorníctve na konci druhej svetovej vojny. On mal CABG v jeho začiatku päťdesiatych rokov, keď bol nový postup. On vyvinul Guillain-Barre syndróm To predtým, než som sa s ním stretol. Mal brušnej aneuryzma, ktorý bol monitorovaný veľkosti. Mal bolesti chrbta mnohokrát vo svojom živote. On vyvinul mezotelióm, rakovinové lézie s pleurálna membrány zdroje, v pľúcach. On vyvinul zápal pľúc-ako choroba a neskôr vyvinutý zlyhanie obličiek a umrel. Existuje dôvod pre všetky vyššie uvedené ochorenia pacienti mali či vyvinutý: základné, zápalové, autoimunitné ochorenie vyvolané určitú rozumne-common mikroorganizmov.

Muž mal bolesti chrbta často vo svojom živote, a on sa vyvíjal mnoho, mnoho typov rakoviny kože na tvári, ušiach, a ruky v priebehu rokov. Ja som celkom dosť chirurgia odstránenie, čas od času, po mnoho rokov. Jeho manželka mala ťažkú ​​ulceróznej kolitídy femorálne neuropatia. Jeho syn mal chronické bolesti chrbta (ischias), to je, sacralis neuropatia. Muž vyvinul nákazlivou chorobou, a ja k nemu správali ako doma. On bol starý čas záznamník a nechcel ísť do nemocnice. Nakoniec zomrel kongestívneho srdcového zlyhania. Ako sa to mohlo stať? Nakoniec všetky hádanky, vrátane zapojenia členov rodiny bude vyriešený!

I worked and worked intensely, 12-14 hours a day for two and one-half years trying to “break the code”, so to speak, on this systemic disease process. Eventually I had a patient who moved here from Plano, Texas. She said she had fibromyalgia. She arrived taking Oxycontin 20 mg twice a day and Roxicet for breakthrough pain (Oh, crumb, another chronic pain patient!). Many of my other patients had had the same diagnosis before they came to my office. I never used the term fibromyalgia, because the anatomy and pathology of the disease had never been described accurately and the name reflected a symptom complex, only. On about the forth, monthly visit with the above patient, I realized she had the same dermatological abnormalities that many of my other patients who experienced neurological pain exhibited. I asked her when they appeared. She said they appeared when she contracted a certain infectious disease. I was incredulous. I had never treated that disease in my life! I went into my office and reviewed the disease in my texts, since I had not read about it since medical school. I then asked her what her symptoms and signs had been. Her description was perfect, right out of the text! Further research indicated that the microorganism causing the disease could possibly cause an autoimmune stimulation. Now, after a few years of academic research, I know it can cause autoimmune responses of many types and the various sub-types of the microorganism can probably cause different and specific autoimmune responses. Perhaps that variability is one of the reasons why endocrine and rheumatoid diseases have the clinical and serological variables that they do.

I did serological tests on the above woman and they were highly positive. I did serological tests on one-hundred, or so, other patients (those who could afford it) and a total of seventy were positive. I realized that the “normal” levels published by laboratories were skewed too high, because more people had the infectious disease than knew it and answered incorrectly on medical history forms when their blood was drawn, from which, the normal titers were determined! I interviewed the seven hundred patients as they came into my clinic monthly and many of them knew they had had an infection similar to that which I described when they were young or later in life. Many times their sickness was confused with the worst chicken pox, flu, mononucleosis, viral meningitis or measles that any one ever had had. It tended to be “within families” and I had families in my group of 700 wherein all members had had the infectious/autoimmune disease and the sequela to it. I learned clinically, and then from older medical literature, that the infectious disease and therefore the autoimmune response could be sub-acute or even chronic and last months and years. Even the carrier state, I think, can cause an autoimmune response!

Now, after two and one-half years, I finally I had a good mental grasp of the microorganism and the disease it causes and also the inflammatory, chronic autoimmune disease that followed persistently, that presents itself in a delayed fashion, initially as an autoimmune vasculitis. I learned how it could cause neuropathy, the rheumatoid diseases, cancer, arteriosclerosis, endocrine diseases, gastrointestinal diseases, dermatological diseases, somatic conditions, pulmonary diseases, including asthma and COPD, and many psychological and neurological conditions such as peripheral neuropathies, MS, probably ALS, autism, ADHD, PTSD, and others. Last year I discovered a book, “The Autoimmune Diseases” ( Rose and McKay, Elsevier Academic Press, 2006), and therein many of the “diseases” that I had discovered to be autoimmune in nature were also categorized as such in the text. Many, many facts, which are presented in texts like “Harrison's Principles of Internal Medicine” and the prior text, give support to my theory. I do not think there are any conflicts. In the latter text, “Harrison's”, one has to “go through the specialties” to glean out the relationships, but that is something a generalist in medicine, like I, have done for thirty years.

I have determined that the inflammatory autoimmune disease, stimulated by the microorganism in question, causes many of the physical and physiological changes that are thought to be the aging process. If a person gets cancer early in life, they had the infectious disease and the autoimmune response worse. If they get a myocardial infarction at thirty-eight, they just had the disease worse. Many people in my group of seven hundred had premature grey hair! The average age of the group of 700 patients was about forty-two, as I mentioned.

I sold my clinics two years ago after I was hassled by the State of Washington Department of Health since seven out of 7000 patients died over a three-year period. They died of complications connected with the infectious/autoimmune disease, not from any adverse treatment I had given. I had attracted a very ill patient group and had 7000 patients enrolled in my three clinics so the number was not so high from a statistical analysis. Since I was 65, I decided to sell my clinics and further my research from an academic approach. I learned, from experience, how academically weak bureaucratic physicians are and how they and other bureaucrats can use official connivance, modern rhetoric in the form of press releases and television announcements, and litigious muscle to further their ill-conceived goals.

Thereafter, I traveled to nine countries and visited clinics and hospitals and took medical histories on patients I met and examined them to some degree. I have continued to do academic research on what has become an abiding interest. I have completed a book of 180 pages, or so, and it is now being edited. I will publish it unless I make a connection with a pharmaceutical company or research institution that is interested in having me join them and investigate this disease further. If I do make a connection, I will wait to publish my book until a mutually appropriate time.

The human and other vertebrates have evolved with the microorganism in question, for millions of years. Vertebrate hosts have genetically evolved to counter the microorganism's antigenic aggression with an antibody response, but unfortunately for us and other vertebrates, the immunological response is an autoimmunological response and we humans and other vertebrates develop chronic autoimmune disease. We have learned, genetically, to counter the autoimmune disease reasonably successfully, however, and we, and members of our species, usually reproduce and maintain our populations, and the microorganism does the same. We have developed a semi-symbiotic relationship.

In history, there have been many epidemics and pandemics and I believe that during those times when environmental factors favored the microorganism, the infections caused acute and highly chronic inflammatory autoimmune disease (there are many autoantigens within the microorganism's structure) that led to the development of some of those pandemics. The Athenian Plague, 430 BC, the Black Plague of the 1300's and the Influenza of 1918 are examples, I believe. All the above great pandemics took place concomitantly with large military operations, the Peloponnesian War, The Thirty Years War, and of course WW I. The Thirty Years War took place at the time of the “mini-ice age in Europe” and the coolness and poor food supply probably was another adverse factor. There is very little sure knowledge concerning the identification of the pathogens that caused the above pandemics. Influenza, means “from the heavens” in Italian, for instance, and it has only of late become to be known as a disease caused by a virus, but again, that is not a sure thing in many cases, historically, since the electron microscope, which is needed to see viruses, was not invented until 1938.

I hypothesize that the microorganism of which I am speaking is the cause of those great medical disasters. The recent increase of fibromyalgia, autism, ADHD, PTSD, TB, MRSA, AIDs, MS, diabetes and cancer etc. are indicators that the autoimmune disease in question is “gaining ground” on the ability of humans to immunologically protect themselves in this temporal cycle. It is a good possibility! The microorganism is ubiquitous to all vertebrate society, so it is a bilateral zooinosis, so to speak, and there is a constant reservoir of organisms in vertebrate life around the world.

Various environmental conditions make the often-subtle infections more common. Living in economically poor societies, existing in crowded conditions, living in more soiled environments, and existing in cooler, damper environments all cause the disease to be more common. Within the military environment, especially overseas, two of the three factors, mentioned above, are prominent: living in crowded environments and living in economically poor societies. I am quite sure that the Vietnam Syndrome and the Iraq War Syndrome are manifestations of the underlying infectious and autoimmune disease of which I am writing.

To je obyčajné pre tých, ktorí sa reumatických chorôb, rakoviny a arteriosklerózy (a aneuryzma) mať neuropatiou. To je obyčajné pre pacientov s AIDS, aby mali neuropatia, reumatických chorôb, rakoviny, psychologické abnormality vrátane homosexuality a iných infekcií, ako viete. Typické texty ako "Zásady Harrisonových of Internal Medicine" uvádza s tým spojených problémov, je uvedené vyššie, u pacientov s AIDS, ale aj to, že majú reumatologické ochorenia paradoxne! V reumatické choroby sú známe ako paraneoplastický, najmä, dermatomyozitída a Wegenerova granulomatóza, ale v mojich pacientov v priebehu rokov, všetci pacienti, ktorá sa vyvinula rakovina, najmenej, mierne reumatoidná artritída. Guillain-Barrého syndróm To je paraneoplastický choroba tiež, a to je v podstate najrozšírenejšie neuropatia, niečo ako akútna RS, ktorý to určite je. Tieto choroby sú považované za paraneoplastický, pretože základné zápalové, autoimunitné ochorenie spôsobuje syndróm sa jedná, ale aj rakovina, ktorá sa často objavuje trochu s nimi.

Organizmu v pochybnosť je endemická v spoločnosti. Je všadeprítomný v prírode a našiel som informácie v ruskej literatúre, že všetky domáce zvieratá proti napadnutiu a sú nositeľmi tohto organizmu v rôznych obdobiach svojho života. Verím, že všetci stavovce, všeobecne trpia infekciou a sú z nosiče, mikroorganizmy v otázke, mnohokrát v živote, tiež.

Pripraviť koncept je: od prvého infekcie mikroorganizmu v pochybnosť, že osoba má vo svojom živote, oni vyvinú zápalové autoimunitné ochorenie na určitej úrovni. Dodatočné infekcie spôsobujú nárast subtílne, alebo nie tak jemné, autoimunitné reakciu! Myslím, že genetika mikroorganizmu sa líšia natoľko, aby sa organizmus "morph" sa niektoré mikroorganizmy prostredie tak, aby mohol existovať v rôznych mikro-anatomických výklenkov. Predchádzajúci myšlienka je hypotéza, ale bolo by jednoduché mikrobiológ skontrolovať.

Ako okrajová poznámka sa zmienim, že som stretol ženu, ktorá žila na ostrove Vancouver, Britská Kolumbia. Ona vyvinula rakovinu krčka maternice počas svojich tridsať a mal chirurgickú liečbu vhodnú pre tento stav. Potom, potom, ona mala rakovinu prsníka v jej polovici štyridsiatych rokov. Mala bilaterálne mastektómií a rekonštrukčnej chirurgie. Pri hovore s ňou som sa dozvedela, že jej otec bol Kanaďan núti zubár. Neexistuje žiadne miesto, s väčšou pravdepodobnosťou zmluvu mikrobiálnej nákazy, než pracovať na zuby ľudí, denne! Jej syn mal Asperger syndróm, porucha autistického spektra duševného stavu. Jej otec zomrel kongestívneho srdcového zlyhania spôsobené kardiomyopatia idiopatickej a sestra mala neurofibromatózy, to všetko spôsobilo, som presvedčený, že táto základná autoimunitné choroby, ktorá je sama spôsobené mikroorganizmami v pochybnosť. Pôvodného stavu, kardiomyopatia, je považovaný v texte, "autoimunitné ochorenie", predtým uvádzané, ktorá sa o autoimunitné povahy. Tá choroba, neurofibromatóza (Von Recklinghausens syndróm) je ochorenie, s ktorým som mal len jeden pacient, ale mám pripojenie na tri iní, a myslím, že to základné, zápalové, autoimunitné ochorenia je spojený s jeho patogenézy.

Mal som dobrého priateľa, a asi pred desiatimi rokmi bol vyvinutý ALS a zomrel. Jeho matka zomrela na MS. Jeho manželka mala operáciu bedrovej za údajné herniated disk, ktorý nebol vyliečiť chirurgicky. Skutočnosťou je, že ona mala sacralis nervu z rovnakého základného, ​​chronické, zápalové, autoimunitné ochorenie jej manžel. Môj priateľ mal určité mentálne vlastnosti spojené s autoimunitné ochorenia a samozrejme nakoniec predstavil s neurologickými príznakmi v súlade s ALS. Jeho syn mal chronické záchvaty. Tieto neurologické syndrómy, v rodine, opäť sa podobajú tým, ktoré som uviedol, v priebehu rokov, v mojej lekárskej praxi v štáte Washington.

Washington State, mimochodom, je, myslím, má ôsmej najvyššiu mieru zasiahnutia na rakovinu zvážení všetkých štátov v USA. Je dobre známe, že útok je vysoká MS v severských krajinách, poriadku a viem, že je to preto, infekcie podľa mikroorganizmu v pochybnosť sú častejšie v chladnejších, viac-vlhkých miestach. MS je bežné v mojej praxi oblasti. K dispozícii je polořadovka-vidieckej ceste severne od Toledo, Wa., Mesto s iba 690 obyvateľov, a traja ľudia, ktorí žijú z nej majú RS a žijú do pol kilometra od seba. Dvaja ďalší ľudia, ktorí vyvinuli MS vyrástol blízko! Tam musí byť logický dôvod! Dôvodom je, nie je pochýb o tom, že všetci chodili do rovnakej školy a mikroorganizmov v pochybnosť bola rozdelená medzi deti, keď chodil do školy!

Spomenul som infekčných chorôb ako je AIDS, TBC a MRSA, pretože sú zvyčajne vysoko nákazlivá, ale s relatívne vysokého stupňa zápalové, autoimunitné ochorenia ochranné imunitný systém je degradovaný, v čase, čo umožňuje tieto relatívne mierne patogény, aby sa viac invazívne a patologické. Existujú aj ďalšie bakteriálne, vírusové, parazitárne a plesňové patogény, ktoré môžu spôsobovať infekcie u tých, ktorí sú imunologicky depresii. Napríklad, možno malária, lepra, spavá choroba a mnoho vírusových ochorení sú členmi rovnakej podmnožiny. V oblastiach, ako Sub-saharskej Afriky, lokalizácia, v ktorom populácie zažije predmet infekčné ochorenia a autoimunitné reakciu na vysokej frekvencii, je pravdepodobné, že obyvateľstvo ako celok, pravdepodobne má závažnou poruchou s ich imunitnej odpovede tak, aby sa ľahko zmluvu na choroby, uvedené.

Tiež, aj keď tie s AIDS majú imunodeficienciou v dôsledku patologického pôsobenia vírusu AIDS sám, pacienti pravdepodobne mal imunitný deficit z autoimunitných ochorení sa jedná a dovolil AIDS vírus napadnúť spočiatku. Je možné, že niektoré poddruhy Staphylococcus aureus sú vysoko odolné voči antibiotikám, vrátane methacillin, pretože mal možnosť vyvíjať gény, ktoré prispievajú k odolnosti voči antibiotikám v týchto ľudí, ktorí mali imunitný systém degradácii v minulosti u autoimunitných ochorení sa jedná. To je ďalší predpoklad v mojej teórie, ale ja mám dôvody pre to, pretože mnoho z mojich pacientov sa objavili nezvyčajné, agresívnych infekcií, najmä ak mali autoimunitné ochorenie vážne.

Ďalšou oblasťou medicíny a ľudského správania som sa dotkol, hore, je spoločný vývoj psychických ochorení štátov a tie sú obvykle popisovaný ako autizmus, ADHD, PTSD, schizofrénia, depresia, bipolárnou poruchou, chronická úzkosť, výbušné osobnosť, riadený, osobnosť typu A, Alzheimerova choroba a Parkinsonova choroba (posledné dva sú pravdepodobné). Iné, jemnejšie psychologické a osobnostné poruchy sú tiež spôsobené tento základný autoimunitné ochorenie, ako je proces učenia deficity. Okrem toho sa chronický únavový syndróm a možno anorexia spôsobené týmto ochorenia. Všetky vyššie uvedené podmienky, existujú centrálny nervový systém neuropatia, to znamená, že centrálnej nervovej prejavy systémové autoimunitné ochorenie, zápalovým procesom. Zápalové autoimunitné ochorenie narušuje krvný mozgovú bariéru, umožňujúci autoimunitné faktory a ďalšie sérové ​​faktory pre vstup do mozgového tkaniva a spôsobiť neurologické poškodenie tkaniva. Čas v živote, závažnosť, chronicity sa podtypy mikroorganizmov, frekvencia infekcií, všetci ktoré majú vplyv na autoimunitné reakcie a schopnosť daného človeka imunitného systému bojovať proti infekčné ochorenia a autoimunitné reakcie, spôsobí zmenu V klinických prejavov psychologických uvedené v vyššie uvedenými podmienkami.

Pre pochopenie systémových autoimunitných zápalových ochorení proces, človek musí duševne odchode z obrázku myslenia a priori, že my, lekári, vedci a lekárske odstávky osoby, ktoré boli podmienené myslieť vývoja choroby. Za šesťdesiat rokov, aspoň sme boli vychovávaní k myslíte, v súlade s "špecializovaných divízií medicíny". Ľudské telo nie je samozrejme oddelené, pohodlne, do systémov s výnimkou ako nástroj na pochopenie anatómie na lekárskej vzdelávanie ako jeden učí, že s výhradou. Človek musí premýšľať, ako telo reaguje: v systémovej móde. Človek si musí uvedomiť, že je infekčné ochorenie, ktoré môže byť akútne a dôležité alebo tak mierne a chronické, že pacient môže cítiť normálne, ale aj príčinou zápalové, autoimunitné útok, zvyčajne jemné, ale ktoré môžu byť akútne a ťažké. Aj nosič stimuluje imunitný stav, a preto autoimunitné reakciu. Je potrebné si uvedomiť, že autoimunitné útok ochabne a toky v priebehu času v rámci jedinca v závislosti na mikrobiálne prostredie, v ktorom človek žije a v závislosti od individuálnej imunitnej odpovede na infekčné proces a autoimunitného procesu.

Je potrebné si uvedomiť, že každá tkanivo, a preto orgán bude reagovať na patologické, zápalové, autoimunitné útok inak. Srdce rozvíja arteriosklerózy, srdcová arytmia, kardiomyopatia a perikarditída, koža sa vyvíja rosacea, erytrodermia, spider Nevim, Nevim, seboroická keratózu (vek známky) a dermatitídu a šedivejúce srsti. Tráviaceho systému, orgány rozvíjať ťažké lézie, vredy, polypy, divertikuly, primárna sklerotizujúca cholangitída, ulcerózna kolitída, Crohnova choroba, autoimunitné hepatitída, zápal žlčníka a pankreatitída. Mozog sa vyvíja funkčné odchýlky, ako je autizmus, ADHD, PTSD schizofrénie, disassociative javu bipolárnej depresie, depresia, učenie deficity, poruchy osobnosti, Alzheimerovej choroby a Parkinsonovej choroby. Mnohí ľudia sú vo väzniciach a nápravných ústavoch a to z dôvodu abnormálneho správania, ktoré sa vyvíjajú z autoimunitné cerebritis. Pacienti môžu rozvinúť vzdelávacie deficity a jeden strát môže byť morálne učenie. Subtílne duševné zmena, ktorá sa koná počas puberty môže byť menený a niektorí jedinci pociťovať zníženú prechod na heterosexuálne orientáciu a pobyt nediferencované v tomto smere, ale vybudovať normálne somatické sekundárne pohlavné znaky, teda homosexuálny jedinec je vyvinutá. Kombinácia výbušné osobnosti, deviantné sexuálnej orientácie, a nemorálne myslenia vzory vyrábať, myslím, že trestné osobnosť. Sme podmienené myslieť si, že ľudia sú jednoducho zlé, ale myslím, že trpí organickou, zápalové, autoimunitné cerebritis, čo spôsobuje ich abnormálne správanie, tendencia.

Mozgovej poruchy rôznymi spôsobmi v závislosti od štruktúry infekčných ochorení, a preto autoimunitné reakcie, a ako autoimunitné útok sa vyvíjal. Väčšina detí s autizmom sú považované pediatrami či detských neurológov. Pacienti, ktorí majú Parkinsonovej choroby sú videné neurológov a internistov alebo psychiatrov, takže podobnosti nie sú zaznamenané v aktuálnom špeciality, klinického usporiadanie. Pokiaľ si myslíte o tom, dieťa s autizmom prvotriedne pôsobí ako miniatúrne jedinca s chorobami vysoko kvalitné Parkinsonovej choroby. Mal som oba typy pacientov v mojej klinike a bol som prekvapený, ako boli oboznámení. Dieťa s autizmom mal vývojovou hemofíliu vzhľadom k autoimunitným ochorením sa jedná tiež. Matka dieťaťa mala lupus erythematosus a fibromyalgii s sedacieho nervu a brachiálneho plexu neuritída, všetci autoimunitné príčiny. Matka dieťaťa bola bezpochyby "mikrobiálne dopravcu", ktorá viedla k jej rozvoju dieťaťa autoimunitné ochorenie prejavujúce sa ťažkým autizmom (autoimunitné cerebritis) na zhruba tebou po rokoch.

Cievne strom vyvíja arterioskleróze, aneuryzma, flebitída, tromboflebitída, tromboembolizmu a lymfodémy. Autoimunitné útok na pohlavné žľazy narušuje meiosis a spôsobuje genetické zmeny, ktoré vedú ku genetickým vrodených vád. Zápalové autoimunitné podobný útok na somatických bunkách spôsobuje somatické genetické odchýlky, ktoré môžu viesť ku klinickej rakoviny. Autoprotilátky môžu prechádzať placentou a spôsobiť veľké množstvo vývojových vrodených vád. Je potrebné si uvedomiť, že jav, ktorý sa objaví v zložitých systémov javí v trochu náhodne!

Tí s autoimunitné zápalové ochorenie obtiažnosti skúsenosti liečenie. Pomaly únie alebo non-union zlomenín, pomalé hojenie chirurgických miest s vývojom keloids a incisional kýl, a zrasty sú u tejto skupiny. Občas ženy, ak dochádza k vysoko kvalitnej autoimunitného ochorenia, môže prejsť protilátky cez placentu a spôsobiť ťažkosti pri embryologické tkanív rovine zlúčenie a tak rázštep podnebia a spina bifida, medzi inými vývojovými vrodených chýb, môže sa vyvíjať. Táto infekčná choroba a autoimmunological odozva je oveľa častejšia u "tretieho sveta", ako je Vietnam, a samozrejme existuje mnoho ciest do tejto krajiny, aby opraviť rázštep podnebia a vývojové abnormality na srdci, napríklad.

Pacienti a lekári všimnete abnormality orgánov zmysly najčastejšie. Oči rozvíjať sivé zákaly, presbyopiou, makulárna degenerácia, glaukóm, odlúčenie sietnice, iritída, uveitída, penguecula vývoj, dvojité videnie, skleritída a choroiditis atď Rokovania zmysel vyvíja tinnitis, a zníženej funkcii. Vestibulárne nerv je možné závadu a fyzická osoba, sa môže vyvinúť závraty. Lícneho nervu abnormality vedú k palsey Bell. Autoimunitné trojklanného nervu spôsobuje migrénu. Reumatoidná artritída tempe mandibulárnej spôsobuje TMJ bolesti hlavy a to nie je nezvyčajné pre oba typy bolestí hlavy existovať súčasne, pretože sú obaja pôsobili v rovnakej základnej autoimunitné vaskulárnej stavu.

Most people have heard about the risk factors of coronary artery disease: a positive family history of CAD, type A personality, high cholesterol, diabetes, hypertension, transverse ear lobe folds (an idea of about 15 years ago), and I will ad my own: neurological back pain: sciatica. The same risk factors fit for those with arteriolar aneurysms and peripheral vascular disease. The reality is that all the markers or risk factors are simply concomitant phenomena caused by the inflammatory, autoimmune disease about which I am writing. The positive family history is not due to genetics, it is because individuals within families are more likely to contract the infection in question, and therefore develop the autoimmune disease, more frequently.

I have been to Vietnam, Taiwan, and Mexico recently for extended periods and I know the underlying infectious disease and the autoimmune response is more severe and endemic in those more economically undeveloped locales than here, in America, and in Western Europe. The microorganism has been brought here, including various strains that are more pathological, and such importation has caused an increase in the commonality and severity of the autoimmune disease process, that is systemic in nature, and therefore the above conditions are more prevalent than, let us say, 30 years ago. There are other influences that have caused the infection and autoimmune response to be more prevalent, also.

Being a general practitioner, and having worked in the US Navy in the USA and overseas, or in small-town clinics all my professional life, so I have not published in academic journals. I did, however speak at the Second World Conference on Immune-Mediated Diseases in Moscow, last September. I was a substitute speaker, for I took the place of a Russian scientist who had had a heart attack, on an afternoon of one of the last days. I think most of the “listeners” were Russian pediatric allergists, since they sponsored the meeting. Most of the international “academics” had left since they were there, basically, to give their own talks. I am not sure if many of the Russians understood my “rapid English” since I only had twenty-five minutes to speak. Since this is a systemic disease process, it is naturally complex. For that reason I have written a book so that I can explain many more of the mechanisms of disease production in the various tissues and organs and how the underlying, systemic, inflammatory autoimmune disease plays the key role.

Most medical and scientific research, nowadays, is conducted via microscopic or submicroscopic means. The articles in the 2000, or so, medical journals printed in the world can attest to that fact. Most research findings do not really affect the practical advancement of medical science wherein the treatment of diseases is improved. My research was of a macroscopic, clinical and epidemiological nature. I used induction to reason out and see the relationships between the biological and clinical observations I have made being a physician. I have seen 230,000 patient interfaces and that comprises a great number of observations. I had a great setting, being an independent clinic owner, in a poor area, for nearly a quarter century. Poor people are sicker people, in general, and being a general practitioner, and treating all diseases, I “had a chance” to put the puzzle together.

Another advantage I had, perhaps, is that I am a former US Marine officer. I was a Phantom II pilot with 146 combat missions in the Vietnam War. While flying a high performance jet, I had to learn to integrate a great number of factors, simultaneously, and perhaps I became something of a systems analyst, at 500kts with people shooting at me! Marines have a saying, “the difficult we do immediately, and the impossible just takes a little longer.” Humorous, it is, but Tarawa, Iwo Jima, and other nasty places were dealt with successfully through perseverance more than intelligence. My investigation took a great amount of perseverance, an experienced knowledge of many disease entities, being located in one clinic for a long period, and I saw, medically, males and females of all ages and for all diseases. I had the perseverance and the sense of duty to my patients to work 12-14 hours a day for two and one-half years and eventually I “figured out” the puzzle, the enigma!

Ďalším krokom v zabezpečenie riadnej uistenie, že moja teória je správna, je to, že budem musieť spojiť s vyšetrovacej skupiny, ktorá má pripojenie k veľkej nemocnice / klinika systému a koordinuje serology a markeru zápalu testovanie skupiny pacientov. Pacienti s: rakoviny prsníka, hrubého čreva, mozgu rakovina, leukémia, cukrovka, Cushingov syndróm, Addisonova choroba, polycystických ovárií choroba, Parkinsonova choroba, Alzheimerova choroba, kôrnatenie ciev, cievna mozgová príhoda, hypotyreóza, ulcerózna kolitída, chronická bolesť z fibromyalgia a neuropatia, ezofagitída, vredy, AIDS, TBC, MRSA, že reumatické ochorenia, Crohnova choroba, žalúdočné vredy a pod

Snáď päťdesiat každého typu pacienta by mohol byť zapísaný do sérologické štúdie. Phlebotomies by mohli byť organizované prostredníctvom nemocnice a kliniky prostredníctvom zmluvnej dohody a každý pacient alebo úradníckej mohol podpísať oprávnenie sklz pre skúšku. Takéto testovanie je veľmi jednoduché na organizáciu, myslím. Ak sú sérologické výsledky sú pozitívne, ako by boli vo svojej vlastnej klinike, to znamená, ak niečo ako 60% pacientov má zvýšené serology, je preukázané, teórie. Hladiny protilátok na zem, v priebehu času, ak pacient nemá infekciu v uplynulom období, ale imunitný systém je stále v prevádzke v patologickom spôsobom, a to iv prípade, že protilátky, ktoré sú tiež protilátky, sú na nižšej úrovni. Pacient je stále naplnený imunologicky reagovať agresívne k opakovanej infekcii v budúcnosti. To je to, čo spôsobuje zhoršenie reumatoidnej artritídy, napríklad bolesti chrbta a prečo zhoršuje: pretože autoimunitné ochorenie zlepší, do určitej miery, pokiaľ človek nemá infekciu tým, že organizmus sa jedná, na určitú dobu, a potom Ak nová infekcia prebieha zápalové autoimunitné ochorenie, bude horšie.

Človek mohol rozhodnúť urobiť ďalšie skúšky na väčšom počte a na viac rôznych kohorty pacientov, okrem toho, aby dôkaz väčšiu firmu. Akonáhle teória je dokázaná, môže začať výskumu v snahe urobiť autoantigen, tvorba autoprotilátok a cieľové tkanivo-blokátory. Prvý a posledný sú zrejme podobné. Skupina liekov z existujúcej liekopisu môžu byť vyvinuté potlačiť autoimunitné reakciu. Mal som veľa, veľa pacientov na výber liekov, ktoré pomohli bez otázok. Vakcína môže byť vyvinutý!

Many people die early in life from cancer, heart disease, and aneurysm formation, because they, more or less, age early. The individual organs that develop clinical abnormalities from the underlying, inflammatory, autoimmune disease exhibit them with some randomness, which would be natural in a complex system. It is quite common, however, for a person to have low back pain, an explosive or driven personality (Type A), some arthritis in the knee, and experience an arthroscopic surgical procedure. Then later, arthritis in the hands may appear and then age marks (seborrheic keratosis) develop. The individual might have had nevi and need to watch for malignant melanoma. After a few years they have a myocardial infarction or angina and have a stent emplaced. Perhaps later, they develop atrial fibrillation, and then ten years later they get cancer. The temporal appearance of the diseases mentioned above, which are really target –organ manifestations of an underlying autoimmune disease, and are in the sequence I noted in the members of families in my area, among others. One phenomenon that takes place, that we just take for granted, is that as we age we get ruddy faces and graying of the hair. Both are manifestations of the subtle, autoimmune, inflammatory disease that we all have! The universal physical changes that all humans experience, commonly termed aging, are, for sure, for the most part, the physical manifestations of this underlying infectious/autoimmune, inflammatory process.

Like all break-throughs in science, I was the receiver of millions of bits of knowledge from my mentors through the years and then from my own clinical experiences. All the bits of “passed-on” knowledge ( I sound like Bill Gates=bits of knowledge) and personal medical observations led to a generalization. Like many new insights it is simple once it is understood, like: E=MC sq. Even the visualization of the disease mentally, is somewhat akin to Einstein's heuristic thoughts that led to the theory of special relativity.

Einstein wrote, the simpler a theory, and the more observations it explains, the more likely it is to be correct (paraphrased). My theory is simple and it explains most of the puzzling observations I have had in medicine for over thirty years, and serological testing and the taking of medical histories proved it is correct.

James W. Goding, MD, Ph.D., Monash University, Australia, wrote in the epilogue of “The Autoimmune Diseases”, “Would the Real Autoantigen Please Stand Up!” He was referring to the concept that there was probably one autoantigen or group of antigens from one source that caused the autoimmune diseases listed in that long text. I have found it, I am very sure.

I know that many would think that I, being an sixty-eight year old osteopathic, general practitioner, may be one of the most unlikely medical professionals to develop a major insight in medicine! I was, however, the one independently seeing patients of both sexes, of all ages, for all diseases, in one community, for a long period, an unusual situation in medicine nowadays in the period of procedural, specialty-dominated medicine. In my setting, I alone had the responsibility to determine what was medically causing disease processes within my patients. I was an independent physician and worked in an economically poor area. I had the independence of thought, to determine what I have managed.

Also, one must realize that John Snow, a general physician in London, did an epidemiological study and determined that cholera was spread by water supplies before the microbiological theory was well developed. In addition, one must remember that Louis Pasteur and Claude Bernard were not connected to a research institute. One could consider that Walter Reed and his physician associates, Dr.Jesse Lazear and Dr. James Carroll, and even Dr. Carlos Findlay, the Cuban physician who advanced the theory that the mosquito transmitted yellow fever twenty years before Dr. Reed's research project, who together proved that Yellow Fever was spread via the mosquito, were simply general practice physicians. To tell you the truth, the division of medicine into specialties has harmed the discovery of disease processes because specialists, by concept and training, develop a constricted view of medical science and t times never see sick patients. Since this autoimmune disease presents primarily as a vasculitis, and since there are no vasculogists (a new word), no one would ever determine that people have a wide-spread, inflammatory, autoimmune, vasculitic disease!

To give you a better idea of how simple it is, just look in “Harrison's Principles of Internal Medicine, 16th Edition”, within the section that discusses rheumatoid arthritis. The information provided indicates that there is no known cause for rheumatoid arthritis (RA), and that it is a systemic, autoimmune disease that features arthritis, neuropathy, and vasculitis, and that it can cause organ infarction, even a myocardial infarction. Earlier editions (the 13th edition, for instance) also indicated that a feverish disease could cause an exacerbation of RA. Since myocardial infarctions are caused by arteriosclerosis, as a general disease process, other clinical manifestations are peripheral vascular disease, stroke, arterial aneurysms and venous abnormalities such as venous thrombosis. I just had to learn what caused the feverish disease that triggered exacerbations of RA, and put the puzzle together. Thereafter, I just had to add on the fact that most people who develop cancer have, at least, one of the rheumatological diseases, for instance rheumatoid arthritis, at least subtlety, and so there is no doubt that the rheumatoid diseases and cancer are caused by the same underlying autoimmune disease process.

Even Galen, the famous Greek physician, scientist and philosopher, in 200 AD, coined the word “rheumatism” because the word-root rheum means phlegm. He knew that respiratory infections that frequently caused expectoration (coughing up phlegm) and coryza (phlegm from the nose), led to a miserable, chronic condition in his patients. He termed it “rheumatismos” or in English, “rheumatism”. Yes, arteriosclerosis, cancer, the endocrine diseases, the rheumatoid diseases, peripheral and central neuropathies and many more conditions are part of the rheumatism concept. They are all end-organ manifestations of the systemic, autoimmune, inflammatory disease of rheumatism!

Philology, the science of language, has, over hundreds of years, incorporated a great amount of wisdom within itself . In the Webster's New Twentieth Century Dictionary, 1976, it mentions under the word rheumatism: “any of various painful conditions of the joints and muscles; especial y, a disease believed to be caused by a microorganism and characterized by inflammation and pain in the joints.”

The “nut” of my theory has been known for thousands of years, but now with added, more recent knowledge from bacteriology, immunology, and the autoimmune concept, and by thinking systemically, as I saw my patients, especially during the clinical, epidemiological investigation I have mentioned, the nature of the disease process let itself be known.

I have presented the case for a disease that is so common, since it is caused by a microorganism ubiquitous to the society of vertebrates, and the autoimmune, inflammatory affects so universal, that we all have it. You, me, my kids, my ex-wife, my neighbors (I know the family: Dad has Charcot-Marie-Toothe syndrome (high arches and neuropathy of the legs), a cardiac stent and then a CABG and between the two was in the hospital for 8 days for “pneumonia with complications”, which was really a disease episode from the organism in question. Both his sons have the disease quite meaningfully as they have chronic pain and peripheral neuropathies. All of us humans in the world have the disease, because the organism is so ubiquitous. Some people and families have it worse, naturally. Those individuals and families often do not function well in life.

Since I have finished a book of approximately 200 pages concerning this disease process I could naturally write on and on. I will not, however, but I will say this: Over the last fifteen years there has been a great increase in the number of cancer, fibromyalgia, chronic pain, and autistic patients and the appearance of many infections such as TB, syphlis, MRSA, etc., in the American scene, of which I am most familiar. There has also been special manifestations of diseases, psychological and physical, in military men returning from overseas duty, especially from Vietnam and the Middle East. The reason this is true, I believe, is that the pathogens that cause the diseases are more common in poor societies and we, by our war activities, make the disease more manifest in the civilians in the war zone and within our own troops. In addition, infections by the microorganism and therefore the autoimmune response has become more meaningful in American society due to the immigration of ten million people from Mexico and Southeast Asia. Frequent international air travel has introduced microorganisms, or more pathological strains of microorganisms, into our country also.

Hopefully, you have found this letter a little entertaining and interesting. I think I am correct concerning the principles of my theory. I have interviewed, medically, over two hundred and thirty thousand patients during 30 year practice period. I was a physician in medicine, with a wide interest and the responsibility for treating my patients with all medical problems. I practiced in an economically poor area, with quite a few Mexican immigrants, so the markers of disease appeared more overtly than in a more affluent community. I have proved my theory via serological testing. I spent nine months visiting nine countries to determine that this disease process is world-wide. I am presenting a new generalization in medicine, a unifying theory of most or many of the idiopathic disease entities that have filled medical books for decades. The guiding theory, and the pathological and immunological principles that support it, will enable medical scientists to “focus” on the cause of diseases (really target-organ manifestations of an underlying autoimmune disease) and not just try this or that random molecule via a clinical trial, to see if it works on this or that malady.

I have had trouble relaying my information to a research organization because I am semi-retired, sixty-eight, an osteopathic general practitioner, and not an allopathic physician, because I have never worked in a research organization and I have not had any research published. Really, I have found that most individuals, who are in investigative organizations, are typically comfortable dealing with professionals similar to themselves and are not overtly open to new ideas from a person not currently in the structured research industry. Naturally, I can understand such reluctance. The reality is, however, millions of researchers world-wide are usually working with a similar mental-set, using similar techniques and intellectual approaches, and the results of research leaves something to be desired since there have been no “major” breakthroughs detailing the cause of a major diseases in decades!

I am interested in collaborating with a research organization that can help further prove my theory and develop the pharmaceuticals needed to control the disease process. I think that the pharmaceuticals will surely be the most helpful to members of human society, and therefore the most profitable, in the history of medical treatment!

I have been a solo practitioner in a small town most of my medical career and have not associated with other physicians much. I have, however, an old professional and personal friend, Albert Mark, who I have known since I was 16, since I worked for him when he was an active pharmacist. His phone is 1-425-454-0300. His e-mail is: AMMark914@gmail.com . You are free to talk to him concerning me, my background, and my ethics. In addition, I still communicate with my anatomy professor from medical school, Jack Julyan, PhD. His e-mail is carol@julyan.org . He knew me quite well and he was a great teacher.
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Thanks for reading this letter. If you have any interest, please contact me at: ecnal-c@hotmail.com , or 360-864-4371. My address is PMB 227; 120 State Ave. NE, Olympia, Wa., 98501

Yours Truly,

Lance W. Christiansen, DO

S pozdravom,

Lance Christiansen, DO.