Kommersialisera bioteknik i Kina

Kära Dr Gingras,

Jag har varit en läkare för en lång period. Jag har gjort en utredning och har lärt orsaken till många idiopatisk sjukdomar inklusive perifera neuropatier, centrala neuropatier, arterioskleros, cancer och andra. Jag inser mina påstående låter pompöst, men liksom de flesta saker, är det enkelt när principer "räknat ut".

Jag söker "en plats för att ytterligare bevisa min teori" och sedan utveckla och tillverka autoantikroppen blockerande medel för att styra den underliggande autoimmun sjukdom som gör att mål-organ manifestationer, vanligtvis anses vara sjukdomar.

Jag bestämde typ av mikroorganism som utlöser sjukdomsprocessen, i huvudsak.

Om du har intresse av att veta mer kontakta mig på min e-post webbplats.

Jag har varit i USMC, i Vietnam som en pilot och även arbetat i Japan i ett år. Jag har varit i Taiwan, men inte Kina. Jag skulle vilja arbeta där ändå.

Jag ägde tre kliniker på en gång, men nu är jag semi-pensionerad och göra akademisk forskning för att stärka den kliniska undersökningen jag gjorde under en treårsperiod. Jag kommer att lägga ett papper om jag kan.

En samlande Theory of Diseases,

Autoimmun-sjukdom och Target-orgel Manifestationer

Jag är en allmänpraktiserande läkare inom medicin, och jag har är jag säker, utvecklat en meningsfull inblick i orsaken till många, hittills, idiopatisk sjukdomar. Idiopatisk sjukdom har beskrivits med ökande frekvens under de senaste sextio år efter de flesta av de smittsamma sjukdomar förstås och kontrolleras med antibiotika av den första halvan av 1900-talet. Hittills har medicinska texter blivit fylld med beskrivningar av tusentals idiopatiska sjukdomar, dessa sjukdomar utan känd orsak, och eftersom deras orsaker inte är kända behandlingarna för dem är sjukdomsförändrande inte sjukdomen härdning.

Överraskande, de flesta idiopatisk sjukdomar är mål-organ manifestation av en systemisk, inflammatorisk, autoimmun-sjukdomar process. Den autoimmun-sjukdom orsakas av en inflammatorisk, autoimmun sjukdom, som i sin tur orsakas eller utlösas av en infektion av en mikroorganism. Det är en mikroorganism som är ganska vanligt, och det är allmänt förekommande för populationer av vertebrater, vilket inkluderar husdjur och människor. Med detta i åtanke, kan en person överväga sjukdomen ett bilateralt zooinosis.

Vissa mål-organ manifestationer av den autoimmuna sjukdomen processen ofta noteras dermatologiskt. Medicinska bedömare brukar inte tro att dermatologiska funktioner såsom nevi, gallring av hud och rynkor bildas, seborroisk keratos, angiom, seborroisk dermatit, eksem, poliosis, grånande av håret osv nödvändigtvis patologiska natur. Ofta tros vara en del av åldrandet. Om däremot utvecklar en person kranskärlssjukdom, cancer, glaukom, blodpropp, en reumatoid sjukdom eller diabetes, när de blir äldre, och problemet kan lokaliseras till ett visst organ med ett formellt utbildad specialist, tros vara en specifik sjukdom där det är verkligen ett mål-organ manifestation av systemisk, autoimmun-medierad sjukdom process.

Jag arbetar som allmänläkare, bestämd att de flesta idiopatisk sjukdomar är mål-organ manifestationer av en systemisk, inflammatorisk autoimmun sjukdom process. Genom att ha en annan utbildningsbakgrund (en del av det inom luftfarten systemanalys) och klinisk inställning till medicin, och genom att behandla män och kvinnor i alla åldrar, för alla sjukdomar, kunde jag få insikter som ledde till en ny filosofi för sjukdom utveckling, en som förklarar orsaken till de flesta idiopatisk sjukdomar, däribland många hudsjukdomar, mag-sjukdomar, neurologiska sjukdomar, cancer, åderförkalkning, de reumatiska sjukdomar, och sjukdomar endokrina, som tillsammans, kan tänkas vara en stor del av åldrandet .

Jag såg över 230.000 patientbesök, inklusive 1000 hembesök, i en fattig, semi och landsbygd loggning gemenskap utan modern industri. Under en lång tid Jag noterade vissa kombinationer av sjukdomar inom familjemedlemmar för upp till fyra generationer. På grund av detta fenomen, och på grund av frekvensen av MS och perifera neuropatier i mitt samhälle, bestämde jag mig för att göra en klinisk och epidemiologisk undersökning. Informationen på följande sidor förklarar min sökning, några av mina fynd, och vissa saker som är lämpliga i framtiden. Jag har inte nämnt att identifiera den mikroorganism som utlöser den autoimmuna svaret, eftersom denna information är min egen kunskap vid denna tidpunkt. Tack för att läsa den långa brev / papper i förväg.

Jag har varit en militär och civil läkare för trettioett år, en klinisk medicinsk teoretiker under de senaste tre åren av min praktik period och en akademisk utredare under de senaste tre åren.

Några vetenskap har upplevt quantum genombrott i det förflutna, till exempel fysik (pun intended), fysikalisk kemi, astronomi och kosmologi, laser vetenskap, immunologi och kanske även de insikter som ledde till transistorn och digitala dator-kod begrepp, som därefter ledde till "datorn revolution". Medicin, som en vetenskaplig strävan har upplevt många genombrott historiskt, men ingen av teoretisk natur som beskriver orsakerna till sjukdomar sedan slutet av 1700-talet eller kanske början av 1800-talet, då hypotesen och sedan teorin utvecklats som mikroorganismer kan orsaka sjukdom. Denna upptäckt har lett till insikten, vilket resulterade i utvecklingen av antibiotika på 1930-talet och 1940-talet. Denna upptäckt var förmodligen den sista stora genombrott i medicin!

Som ni vet har diagnostik och behandling insatser utvecklats under de senaste sextio åren, genom att låna från andra högteknologiska områden som elektronik, laser vetenskap, ultraljud, biokemi, och datorteknik, men inte från insikter bestäms direkt från teoretisk medicin, som skulle kunna ge en direkt metod av den typ av sjukdomens utveckling och därför dess behandling. Det finns många högteknologiska hjälpmedel för att minimera effekterna av sjukdomen på en viss organ eller för att göra en mer definitiv diagnos, men återigen, inverkan av sjukdomar som förändras och de inte vetenskapligt närma sig genom att först bestämma deras orsaker .

Utvecklingen av vetenskapen om genetik, stamceller koncept, och andra nya begrepp inom biologi, gett upphov till idén att använda sådana meningsfulla och ofta komplexa upptäckter kommer att leda till en ny behandling för "det ena eller sjukdom", även om orsaken till sjukdom är okänd. Det alltid verkar vara en ny "skandalhistoria '" inom medicinen.

Under de sista tre åren av min praktik-period genomförde jag en epidemiologisk, klinisk undersökning och därefter har jag genomfört en tvåårig epidemiologisk, akademiska och historiska medicinska forskningsprojekt, de uppgifter från vilka, överväldigande stöder min teori. Över en niomånadersperiod reste jag till nio länder och besökt kliniker och sjukhus och pratade med och undersökte människor jag träffat på olika platser. Jag har försäkrat mig om att den mikrobiella infektioner och autoimmuna sjukdom som det utlöser, som orsakar många typer av slut-organ manifestationer, däribland cancer, åderförkalkning, fosterskador och reumatiska sjukdomar, till exempel, är en som finns över hela världen, som jag hade teorin, men det är naturligtvis allvarligare i vissa lokaler i världen än andra.

En del av mina tankeprocesser inblandade insikter som inträffat under den långa historien om medicin och hur de medicinska begreppen sjukdom uppkomst samt behandlingar för dem har utvecklats genom tiderna. Som ni väl vet, orsakade infektionssjukdomar stora hälsoproblem för mänskligheten otaliga århundraden, men uppkomsten av mikrobiologi och sedan upptäckten av hygieniska metoder och antibiotika, i mitten av 1800-talet till mitten av-1900-talet minskade frekvensen och betydelsen av infektionssjukdomar . Innan den period som nämns var även sjukdomar orsakade av mikroorganismer idiopatisk i naturen.

Sedan 1930-talet, när antibiotika började användas kliniskt, medicinska texter har "domineras" av beskrivningar av förhållanden som verkligen idiopatisk sjukdomar: cancer, perifera neuropatier, åderförkalkning, de olika reumatiska sjukdomar, olika sjukdomar endokrina, benskörhet, Alzheimers sjukdom, Parkinsons sjukdom, autism, ADHD PTSD, fibromyalgi och många fler sjukdomar av denna typ. Dessa och förmodligen 2000 ytterligare idiopatisk sjukdomar kategoriseras inom medicinska texter, t.ex. "Harrisons Principles of Internal Medicine" och är idiopatisk, finns det ingen känd orsak för någon av dem. Om orsaken till sjukdomar som inte är kända, behandlingar är sjukdomsförändrande, inte sjukdomen härdning, för det mesta. Som ett exempel på denna situation är det vanligt att ta bort en persons gallblåsan på grund av inflammation, men kirurger sällan fråga varför gallblåsan var inflammerad i första hand! Patienter med MS har markörer för inflammation och kalkinlagrade insättningar i det centrala nervsystemet, men sällan gör praktiserande neurologer på allvar försöka fastställa orsaken till MS. Patienter som har cancer har ofta neurologiska smärta, men ingen vet varför de har en sådan smärta. Patienter med AIDS får ofta reumatiska tillstånd, neuropatier, infektioner och cancer, men lite är känt varför de alla finns i denna undergrupp av patienter.

Jag har bestämt orsak, en underliggande systemisk orsak, för de flesta idiopatisk sjukdomar och jag har gett en beskrivning av min upptäckt nedan. Man kan säga att jag har upptäckt en enande teori om idiopatisk sjukdomar, för det skulle vara statistiskt ovanlig, och kanske omöjligt, att det finns 2000 orsaker till år 2000, eller mer, sjukdomar som fyller medicinska texter och med vilken läkare och medicinska utredare hantera, och förbryllad, dagligen.

Jag har varit en allmän praxis läkare, både i den amerikanska flottan och i det civila livet för nästan 30 år, men under de senaste sex åren, är den bästa beskrivningen av min verksamhet som jag har jobbat som en teoretisk, medicinsk utredare. Jag var en jet pilot i US Marine Corps, överraskande under mina sena tjugoårsåldern och början av trettiotalet, och sedan, eftersom jag ursprungligen hade en examen i biologi från Whitman College, I omskolas själv, genom att ta pre-medicin studier vid University of Washington och läkarutbildningen vid Chicago College of Osteopathic Medicine, i en medicinsk karriär. Jag tränade medicin i marinen som en allmän läkare / flight kirurg för fem år under aktiv tjänst och fem år som en reservist. För tjugotre år, därefter var jag en liten stad allmänläkare. Jag arbetade hela tiden mentalt i ett försök att fastställa orsakerna till sjukdomarna, eftersom jag tänkte en del av min plikt som läkare skulle bli läkare, utredare, samt en är en diagnostiker och behandlande läkare.

Jag tränade i en semi-landsbygd i Egentliga Washington i över tjugo år. Jag var en liten entreprenör i medicin, för jag utvecklat tre kliniker och hade tre läkare assistenter hjälper mig, men jag personligen såg de flesta av de allvarliga sjukdomsfall. Jag hade totalt inskrivning av 7000 patienter i mina kliniker, så jag hade en stor volym av fallen. Jag var stolt, efter att jag hade ett antal års erfarenhet, vid behandling av alla typer av medicinska problem, både för män och kvinnor i alla åldrar och inte fungerar som en transportör och skicka patienter med meningsfulla sjukdomar till specialister. Naturligtvis hänvisade jag patienter till specialister på större operation, inre avgränsning, imaging förfaranden och ICU sjukhusvård sedan jag praktiserade för långt ifrån ett sjukhus att ha en sådan praxis. En sådan upplevelse inom medicinen är inte vanligt nuförtiden, eftersom för femtio år eller mer läkemedel har splittrats i konstgjorda förfaranden, ålder definierade, orgel orienterat, system-relaterade relaterade, sjukdom och politiskt bestämda (Family Practice) specialiteter.

Efter att ha sett patienter om tjugofem år blev jag lite inåtvänt och insåg att om inte en patient hade haft en stukning, en skärsår eller en fraktur, eller om de hade haft en infektion, var nästan hela resten av de erfarna medicinska problem hos patienter idiopatisk (deras orsaker är inte kända!). Jag insåg att de flesta behandlingar för idiopatisk tillstånd hade utvecklats genom trial and error metoder genom tiderna och den moderna versionen av dessa insatser är "kliniska prövningar" som du är, utan tvekan, mycket bekant. Det fanns situationer där behandling av ovanstående villkor, rivsår, frakturer, stukningar och infektioner, var komplicerat. Långsam läkning av sår eller kirurgiska platser med bildandet av incisional bråck, var keloid utveckling (stora ärr) och interna sammanfogningar vanligt. De icke-fackligt eller fördröjd förening av frakturer och stukningar som orsakade kronisk smärta och svullnad i månader och ibland år inträffade något ofta. Ibland var en annan "idiopatisk sjukdom namnet" appliceras för att förklara patientens smärta: reflexsympatisk dystrofi eller komplext regionalt smärtsyndrom. Ingen säker förklaring till orsaken till dessa syndrom hade någonsin fått, exakt, i medicinska texter. En del infektioner är mycket svåra att behandla även med befintliga antibiotika. Det verkade vara något ockult på gång.

Jag arbetade i en loggning och frästa området. Jag tränade i den lilla staden Toledo, Washington efter att jag var en Navy läkare, eftersom ägaren, som hade hjärt by-pass operation ville gå i pension och han "sålde ut" till mig för ingenting ner. Jag ville vara lite isolerad från "specialitet medicin" eftersom jag inte ville vara bara en patient transportör som jag hade varit i marinen. Jag var säkert inte en transportör och jag var upptagen från första dagen, där jag såg 40-sex patienter i en 12 timmars skift. Jag arbetade nästan lika stabil i 21 år.

Under de senaste fem eller sex år har jag bestämt att neurologiska länd-och livmoderhalscancer spinal Smärtan var inte det mesta, som orsakas av bråck spinal skivor. Det var sällsynt att en patient förbättras, inom rimlig tid, efter lumbal eller cervikal spinal kirurgi! Jag behandlade många, många fall genom åren. Jag bestämde mig för att göra en epidemiologisk, klinisk undersökning och försöka ta reda på den "sanna orsaken" för ländryggen / skinkan smärta och neuropati till nedre extremiteten och skuldra / nacke smärta och neuropati till den övre extremiteten. Föga anade jag att jag var där själv i ett många år projekt!

Under en två och en halv år jag lockade nästan 700 eländiga, smärtsamma patienter till följd av svår perifer neuropati som de lidit. Man skulle anser dem vara "värsta slutet av klockformade kurva". Många av patienterna, troligen 40% hade haft ryggkirurgi och vissa patienter drabbades många, många operationer. En kvinnlig patient hade fyra livmoderhalscancer operationer och tre länd operationer som utförs av samma neurokirurgen! Hon var inte bättre för sina erfarenheter. En man hade upplevt åtta lumbala operationer och var inte bättre heller. Det var vanligt att ha neurologiska problem i en nedre och en övre extremiteten och ibland i alla fyra extremiteter. Det var något vanligt många medlemmar i en given familj ha neurologiskt orsakat nedre eller övre ryggsmärtor! Det verkade som det fanns en systemisk, något smittsam, ockult, sjukdomsprocess pågår, men på något sätt lokaliserad i nerverna i ländryggen / skinkan och axel / hals-området.

Under min kliniska, epidemiologiska undersökningar, använde jag de tekniker någon läkare kunde använda. Jag gjorde fysiska undersökningar och analytiska, neurologiska kroppsundersökningar på mina patienter, men jag använde dem intensivt och upprepade gånger. Jag gjorde personliga och familjens medicinska historia intensivt och upprepade gånger, också. Jag konstaterat att de neurologiska problem ligger djupt i skinkan och axlar, och inte i ryggen! Jag insåg att smärta är bara en manifestation av inflammation (dolor, rubor, tumör, Calor = från medicin 101), men jag visste inte vad som orsakade inflammationen.

Jag insåg att dessa allvarligt smärtsamma patienter hade liknande dermatologiska avvikelser, och de flesta hade någon form av reumatiska sjukdom. Reumatoid artrit, en historia av juvenil reumatoid artrit, erythematosus, scleraderma, Wegeners granulomatos, Sjögrens syndrom, blandad bindvävssjukdom, ankyloserande spondylit och psoriasis, lupus var representerade i gruppen. Naturligtvis var mild reumatoid artrit är den vanligaste. Jag insåg att dessa sjukdomar var alla inflammatoriska och autoimmuna i naturen.

Många patienter hade en endokrin villkor: hypotyreos, hypoparatyreoidism, Addisons sjukdom, var Cushings syndrom, diabetes, hypofys, testiklar och avvikelser äggstockarna vanligt. Jag insåg att många av dessa sjukdomar var också autoimmun karaktär.

Jag gjorde en sökning av medicinsk litteratur och fann sjukdomen av autoimmun-medierad neuropati. Jag insåg att mina patienter hade det problemet: autoimmun-medierad, vaskulit neuropati. Resultaten kom från Mayo Clinic perifer nerv-koncernen och Weill Medical College, som är en del av Cornell University.

Så småningom lärde jag hur den autoimmuna-medierad vaskulit neuropati traumatiskt kan förvärras, lokalt, och orsakade den något fokuserad smärta djupt i lumbosakrala / skinkan området och axel / hals-området. Patologi inte låg i ländryggen eller halsryggen, som jag nämnde ovan, DÄR kirurgiska ingrepp är fokuserade, men avses smärta mönster gjorde smärtan stråla ut i dessa spinal områden. Det finns några diskbråck antar jag, men inte många. Kirurgi för dem är dock ganska vanligt! Med en touch av ironi jag kan säga att för en tid sedan, blödde välmenande och välrenommerade läkare patienter för alla typer av problem också.

När jag höll på att arbeta med problemet, lockade jag fler och fler patienter, och till slut insåg jag att många patienter hade haft eller utvecklar cancer när jag såg dem. Sjuttio, av 700, hade eländiga, smärtsamma, patienter som kom till mig på grund av kroniska smärtsamma neuropatier, hade eller utvecklade cancer. Den genomsnittliga åldern var cirka 43, eller så, och alla typer av cancer var representerade, men naturligtvis är de vanligaste typerna såsom bröst, var livmoderhalscancer, hud och kolon den vanligaste.

Vissa patienter hade haft många fall av cancer. One woman who was born in Manitoba, who I interviewed where she lived on Vancouver Island, had had four major cancers and I noted that she had a squamous cell carcinoma on her face during my first interview. She had had cervical cancer, breast cancer, colon cancer, and then another breast cancer, and squamous cell cancer, over a thirty-year period. There is no way a person could develop five cancers unless there was an underlying disease process stimulating the pathological, somatic, genetic changes. I learned that she became severely ill with an infectious disease at the hospital where she was born and was not expected to live. She was “tagged” with an autoimmune disease nearly from birth and developed the five cancers secondary to the autoimmune, inflammatory assault during her lifetime!

Another woman, who was in chronic pain for previously diagnosed fibromyalgia developed a sarcoma on her anticubital fossa (anterior side of the elbow) as I was seeing her. Another woman had developed Paget's breast cancer and chronic lymphocytic leukemia, over a three-year period. The patient with Wegener's granulomatosis developed leukemia and she had had cervical cancer earlier in her life. The man with ankylosing spondylitis had a large basal cell carcinoma on his nose. A man who had chronic sciatic back pain, and also ulcerative colitis, which is known to be autoimmune in nature, developed colon cancer.

One man who was in his upper seventies had been my patient for twenty-one years. He was sick when he was a small boy and was severely sick when he was in the US Navy at the end of WW II. He had had a CABG in his early fifties when it was a new procedure. He developed Guillian-Barre' syndrome before I met him. He had an abdominal aneurysm that had been monitored for size. He had had back pain many times in his life. He developed a mesothelioma, a cancerous lesion with a pleural membrane source, in the lungs. He developed a pneumonia-like disease and thereafter developed renal failure and died. There is a reason for all of the medical conditions the above patients had had or developed: an underlying, inflammatory, autoimmune disease triggered by a certain reasonably-common microorganism.

A man had had back pain frequently in his life, and he had developed many, many skin cancers on his face, ears, and hands through the years. I did quite a bit of surgery removing them, from time to time, for many years. His wife had ulcerative colitis and severe femoral neuropathy. His son had chronic back pain (sciatica), that is, sacral plexus neuropathy. The man developed an infectious disease and I treated him at home. He was an old-time logger and didn't want to go to the hospital. Eventually he died of congestive heart failure. How could that have happened? Eventually all the puzzles, including the involvement of family members would be solved!

I worked and worked intensely, 12-14 hours a day for two and one-half years trying to “break the code”, so to speak, on this systemic disease process. Eventually I had a patient who moved here from Plano, Texas. She said she had fibromyalgia. She arrived taking Oxycontin 20 mg twice a day and Roxicet for breakthrough pain (Oh, crumb, another chronic pain patient!). Many of my other patients had had the same diagnosis before they came to my office. I never used the term fibromyalgia, because the anatomy and pathology of the disease had never been described accurately and the name reflected a symptom complex, only. On about the forth, monthly visit with the above patient, I realized she had the same dermatological abnormalities that many of my other patients who experienced neurological pain exhibited. I asked her when they appeared. She said they appeared when she contracted a certain infectious disease. I was incredulous. I had never treated that disease in my life! I went into my office and reviewed the disease in my texts, since I had not read about it since medical school. I then asked her what her symptoms and signs had been. Her description was perfect, right out of the text! Further research indicated that the microorganism causing the disease could possibly cause an autoimmune stimulation. Now, after a few years of academic research, I know it can cause autoimmune responses of many types and the various sub-types of the microorganism can probably cause different and specific autoimmune responses. Perhaps that variability is one of the reasons why endocrine and rheumatoid diseases have the clinical and serological variables that they do.

I did serological tests on the above woman and they were highly positive. I did serological tests on one-hundred, or so, other patients (those who could afford it) and a total of seventy were positive. I realized that the “normal” levels published by laboratories were skewed too high, because more people had the infectious disease than knew it and answered incorrectly on medical history forms when their blood was drawn, from which, the normal titers were determined! I interviewed the seven hundred patients as they came into my clinic monthly and many of them knew they had had an infection similar to that which I described when they were young or later in life. Many times their sickness was confused with the worst chicken pox, flu, mononucleosis, viral meningitis or measles that any one ever had had. It tended to be “within families” and I had families in my group of 700 wherein all members had had the infectious/autoimmune disease and the sequela to it. I learned clinically, and then from older medical literature, that the infectious disease and therefore the autoimmune response could be sub-acute or even chronic and last months and years. Even the carrier state, I think, can cause an autoimmune response!

Now, after two and one-half years, I finally I had a good mental grasp of the microorganism and the disease it causes and also the inflammatory, chronic autoimmune disease that followed persistently, that presents itself in a delayed fashion, initially as an autoimmune vasculitis. I learned how it could cause neuropathy, the rheumatoid diseases, cancer, arteriosclerosis, endocrine diseases, gastrointestinal diseases, dermatological diseases, somatic conditions, pulmonary diseases, including asthma and COPD, and many psychological and neurological conditions such as peripheral neuropathies, MS, probably ALS, autism, ADHD, PTSD, and others. Last year I discovered a book, “The Autoimmune Diseases” ( Rose and McKay, Elsevier Academic Press, 2006), and therein many of the “diseases” that I had discovered to be autoimmune in nature were also categorized as such in the text. Many, many facts, which are presented in texts like “Harrison's Principles of Internal Medicine” and the prior text, give support to my theory. I do not think there are any conflicts. In the latter text, “Harrison's”, one has to “go through the specialties” to glean out the relationships, but that is something a generalist in medicine, like I, have done for thirty years.

I have determined that the inflammatory autoimmune disease, stimulated by the microorganism in question, causes many of the physical and physiological changes that are thought to be the aging process. If a person gets cancer early in life, they had the infectious disease and the autoimmune response worse. If they get a myocardial infarction at thirty-eight, they just had the disease worse. Many people in my group of seven hundred had premature grey hair! The average age of the group of 700 patients was about forty-two, as I mentioned.

I sold my clinics two years ago after I was hassled by the State of Washington Department of Health since seven out of 7000 patients died over a three-year period. They died of complications connected with the infectious/autoimmune disease, not from any adverse treatment I had given. I had attracted a very ill patient group and had 7000 patients enrolled in my three clinics so the number was not so high from a statistical analysis. Since I was 65, I decided to sell my clinics and further my research from an academic approach. I learned, from experience, how academically weak bureaucratic physicians are and how they and other bureaucrats can use official connivance, modern rhetoric in the form of press releases and television announcements, and litigious muscle to further their ill-conceived goals.

Thereafter, I traveled to nine countries and visited clinics and hospitals and took medical histories on patients I met and examined them to some degree. I have continued to do academic research on what has become an abiding interest. I have completed a book of 180 pages, or so, and it is now being edited. I will publish it unless I make a connection with a pharmaceutical company or research institution that is interested in having me join them and investigate this disease further. If I do make a connection, I will wait to publish my book until a mutually appropriate time.

The human and other vertebrates have evolved with the microorganism in question, for millions of years. Vertebrate hosts have genetically evolved to counter the microorganism's antigenic aggression with an antibody response, but unfortunately for us and other vertebrates, the immunological response is an autoimmunological response and we humans and other vertebrates develop chronic autoimmune disease. We have learned, genetically, to counter the autoimmune disease reasonably successfully, however, and we, and members of our species, usually reproduce and maintain our populations, and the microorganism does the same. We have developed a semi-symbiotic relationship.

In history, there have been many epidemics and pandemics and I believe that during those times when environmental factors favored the microorganism, the infections caused acute and highly chronic inflammatory autoimmune disease (there are many autoantigens within the microorganism's structure) that led to the development of some of those pandemics. The Athenian Plague, 430 BC, the Black Plague of the 1300's and the Influenza of 1918 are examples, I believe. All the above great pandemics took place concomitantly with large military operations, the Peloponnesian War, The Thirty Years War, and of course WW I. The Thirty Years War took place at the time of the “mini-ice age in Europe” and the coolness and poor food supply probably was another adverse factor. There is very little sure knowledge concerning the identification of the pathogens that caused the above pandemics. Influenza, means “from the heavens” in Italian, for instance, and it has only of late become to be known as a disease caused by a virus, but again, that is not a sure thing in many cases, historically, since the electron microscope, which is needed to see viruses, was not invented until 1938.

I hypothesize that the microorganism of which I am speaking is the cause of those great medical disasters. The recent increase of fibromyalgia, autism, ADHD, PTSD, TB, MRSA, AIDs, MS, diabetes and cancer etc. are indicators that the autoimmune disease in question is “gaining ground” on the ability of humans to immunologically protect themselves in this temporal cycle. It is a good possibility! The microorganism is ubiquitous to all vertebrate society, so it is a bilateral zooinosis, so to speak, and there is a constant reservoir of organisms in vertebrate life around the world.

Various environmental conditions make the often-subtle infections more common. Living in economically poor societies, existing in crowded conditions, living in more soiled environments, and existing in cooler, damper environments all cause the disease to be more common. Within the military environment, especially overseas, two of the three factors, mentioned above, are prominent: living in crowded environments and living in economically poor societies. I am quite sure that the Vietnam Syndrome and the Iraq War Syndrome are manifestations of the underlying infectious and autoimmune disease of which I am writing.

It is common for those with the rheumatoid diseases, cancer and arteriosclerosis (and aneurysms) to have neuropathies. It is common for patients with AIDS to have neuropathies, rheumatoid diseases, cancer, psychological abnormalities including homosexuality, and other infections, as you know. Typical texts like “Harrison's Principles of Internal Medicine” mentions the associated problems, mentioned above, in AIDS patients, but also that they have rheumatological disease paradoxically! The rheumatoid diseases are known to be paraneoplastic, especially, dermatomyositis and Wegener's granulomatosis, but in my patients through the years, all patients that developed cancer had, at least, mild rheumatoid arthritis. Guillain-Barre' syndrome is a paraneoplastic disease also, and it is basically a wide-spread neuropathy, something like acute MS, which it surely is. Those diseases are thought to be paraneoplastic, because the underlying inflammatory, autoimmune disease causes the syndrome in question, but also the cancer that somewhat frequently appears with them.

The organism in question is endemic in society. It is ubiquitous in nature and I found information in Russian literature that all domestic animals have infections by and are carriers of this organism at various times in their lives. I believe all vertebrates, in general, suffer infections from and are carriers of, the microorganism in question, many times in their lives, also.

A prime concept is: from the first infection by the microorganism in question that a person has in their life, they develop the inflammatory autoimmune disease at some level. Additional infections cause an increase in the subtle, or not so subtle, autoimmune response! I think the genetics of the microorganism is varied enough to enable the organism “morph” with certain micro-environments so as to be able to exist in different micro-anatomical niches. The previous idea is a hypothesis, but it would be easy for a microbiologist to check.

As a side-note I will mention that I met a woman who lived on Vancouver Island, British Columbia. She developed cervical cancer during her late twenties and had the surgical treatment appropriate for that condition. Then, thereafter, she had breast cancer in her mid-forties. She had bilateral mastectomies and reconstructive surgery. While talking with her I learned that her father had been a Canadian Forces dentist. There is no place more likely to contract microbial disease, than working on people's teeth, daily! Her son had Asperger's syndrome, an autistic spectrum mental condition. Her father died of congestive heart failure caused by idiopathic cardiomyopathy, and a sister had neurofibromatosis, all caused, I believe, by this underlying autoimmune disease that is itself caused by the microorganism in question. The former condition, cardiomyopathy, is considered in the text, “The Autoimmune Diseases”, previously cited, to be of an autoimmune nature. The latter disease, neurofibromatosis (Von Recklinghausens's syndrome), is a disease with which I had only one patient, but I have connections to three others, and I think this underlying, inflammatory, autoimmune disease is connected to its pathogenesis.

I had a good friend, and about ten years ago he developed ALS and died. His mother died from MS. His wife had lumbar surgery for an alleged herniated disc that was not cured by surgery. The reality is that she had sacral plexus neuritis from the same underlying, chronic, inflammatory, autoimmune disease her husband had. My friend had certain mental characteristics connected to the autoimmune disease and, of course, he eventually presented with neurological symptoms consistent with ALS. His son had chronic seizures. These neurological syndromes, within families, again, are similar to those I noted, through the years, in my practice of medicine in Washington State.

Washington State, by the way, has, I believe, has the eighth highest attack rate for cancer considering all the states in the USA. It is well-known that the MS attack rate is high in northern tier countries and I know it is because infections by the microorganism in question are more common in cooler, more-damp locales. MS is common in my practice area. There is a semi-rural road just north of Toledo, Wa., a town with only 690 inhabitants, and three people who live thereon have MS and they are living within a half-mile of each other. Two other people who developed MS grew up close by! There has to be a logical reason! The reason is, no doubt, that they all went to the same schools and the microorganism in question was spread amongst the children as they attended school!

Jag nämnde smittsamma sjukdomar som aids, MRSA och tuberkulos, eftersom de inte brukar vara mycket smittsam, men med en relativt hög kvalitet inflammatorisk, autoimmun sjukdom det skyddande immunförsvaret bryts ned med tiden, tillåter dessa relativt milda patogener att bli mer invasiva och patologiska. Det finns andra bakteriella, virala, parasitiska och svamppatogener, vilka kan orsaka infektioner i de som är immunologiskt nedtryckt. Exempelvis kanske malaria, lepra, sömnsjuka, och många virussjukdomar är medlemmar av samma underuppsättning. Inom områden som Afrika söder om Sahara, en lokal där befolkningen upplever ämnet infektionssjukdomar och autoimmuna respons på en hög frekvens, är det troligt att befolkningen som helhet, förmodligen har ett svårt nedsatt njurfunktion med deras immunsvar så att De kontrakt enkelt de sjukdomar som nämns.

Dessutom, även om de med aids har immunbrist på grund av patologiska verkan AIDS-viruset i sig, hade patienterna troligen immunologiska brist från den autoimmuna sjukdomen i fråga och det tillåtet AIDS-viruset att invadera början. Det kan vara att vissa underarter av Staphylococcus aureus är mycket motståndskraftiga mot antibiotika, inklusive methacillin, eftersom den har haft möjlighet att utvecklas gener som bidrar till antibiotikaresistens i dessa människor, som har haft immunsystemet försämring tidigare av den autoimmuna sjukdomen i fråga. Detta är en annan hypotes i min teori, men jag har skäl för det, eftersom många av mina patienter utvecklade ovanliga, aggressiva infektioner särskilt om de hade den autoimmuna sjukdomen på allvar.

Ett annat område medicin och mänskligt beteende har jag berört ovan är den gemensamma utvecklingen av psykologiska sjukdomstillstånd och dessa brukar beskrivas som autism, ADHD, PTSD, schizofreni, depression, manisk-depressiv sjukdom, kronisk ångest, explosiva personlighet, driven, typ A personlighet, Alzheimers sjukdom och Parkinsons sjukdom (de sista två är troligt). Andra, mer subtila psykologiska och personlighet avvikelser orsakas också av denna underliggande autoimmun sjukdom process, till exempel lärande underskott. Dessutom är kroniskt trötthetssyndrom och kanske anorexia nervösa orsakas av denna sjukdomsprocess. Alla ovan nämnda betingelser existerar som det centrala nervsystemet neuropatier, dvs det centrala nervsystemet manifestationer av en systemisk autoimmun inflammatorisk sjukdom processen. Den inflammatoriska autoimmun sjukdom stör blod-hjärnbarriären så att autoimmuna faktorer och andra serum faktorer för att komma in i hjärnan vävnaderna och orsaka neurologiska vävnadsskada. Den tid i livet, svårighetsgraden, kroniciteten de undertyper av mikroorganism, frekvensen hos den infektion, orsakar samtliga vilket påverka det autoimmuna svaret, och förmågan hos en given person immunsystem att bekämpa infektionssjukdomar och autoimmuna svaret, kan variationen I kliniska psykologiska manifestationer noteras i ovanstående villkor.

För att förstå systemisk autoimmun inflammatorisk sjukdom process, måste man mentalt ut från a priori tanken bild, att vi läkare, medicinska forskare och lay-personer, har betingats att tänka sjukdomsutvecklingen. För sextio år, åtminstone har vi utbildat att tänka enligt "specialist divisionerna medicin". Den mänskliga kroppen är inte naturligt segregerat, bekvämt, i system utom som ett verktyg för att förstå anatomin i den medicinska utbildningen som en lär det ämnet. Man måste tänka som kroppen reagerar: i en systemisk sätt. En person måste inse att det är en smittsam sjukdom, som kan vara akut och viktigt eller så mild och kroniska att patienten kan känna normal, men båda orsakar en inflammatorisk, autoimmun attack, oftast subtila, men som kan vara akut och allvarlig. Även den bärartillstånd stimulerar ett immunsvar och är därför en autoimmun respons. Man måste inse att den autoimmuna attacken uppgångar och nedgångar över tid inom det individuella beroende på den mikrobiella miljön där man bor och beroende på det individuella immunsvar mot smittsamma processen och den autoimmuna processen.

Man måste inse att varje vävnad och därför organ kommer att svara på den patologiska, inflammatorisk, autoimmun attack annorlunda. Hjärtat utvecklar åderförkalkning, hjärtarytmier, kardiomyopati och perikardit, huden utvecklar rosacea, erytrodermi, spindel nevi, nevus, seborroisk keratos (ålder varumärken) och dermatit och grånande av håret. Det gastrointestinala systemet organ utveckla esofagit, magsår, polyper, diverticula, primär skleroserande kolangit, ulcerös kolit, Crohns sjukdom, autoimmun hepatit, kolecystit, och pankreatit. The brain develops functional abnormalities such as autism, ADHD, PTSD, schizophrenia, disassociative phenomenon, manic-depression, depression, learning deficits, personality disorders, Alzheimer's disease and Parkinson's disease. Many humans are in jails and prisons because of the behavioral abnormalities they develop from autoimmune cerebritis. Patients can develop learning deficits and one of the losses can be moral learning. The subtle mental change that takes place during puberty can be altered and some individuals experience a decreased transition to the heterosexual orientation and stay non-differentiated in that respect, but they develop normal somatic secondary sexual characteristics, thus the homosexual individual is developed. A combination of the explosive personality, deviant sexual orientation, and immoral thinking patterns produce, I think, the criminal personality. We are conditioned to think that people are just bad, but I think they suffer from an organic, inflammatory, autoimmune cerebritis, which causes their abnormal behavioral tendencies.

The brain malfunctions in various ways depending on the pattern of infectious disease and therefore the autoimmune response, and how the autoimmune attack has developed. Most children with autism are treated by pediatricians or pediatric neurologists. Patients who have Parkinson's disease are seen by neurologists, internists, or psychiatrists, so the similarities are not noticed in the current specialty, clinical arrangement. If you think about it, a child with high-grade autism acts like a miniature individual with high-grade Parkinson's disease. I have had both types of patients in my clinic and I was surprised how familiar they were. The child with autism had developmental hemophilia due to the autoimmune disease in question also. The child's mother had lupus erythematosis and fibromyalgia with sciatic neuritis and brachial plexus neuritis, all of an autoimmune cause. The child's mother was, no doubt, the “microbial carrier” that led to her child developing autoimmune disease manifested by severe autism (autoimmune cerebritis) at about thee years old.

The vascular tree develops arteriosclerosis, aneurysms, phlebitis, thrombophlebitis, thromboembolism and lymphedema. The autoimmune attack on the gonads disturbs meiosis and causes genetic changes that lead to genetic birth defects. A similar inflammatory autoimmune attack on somatic cells causes somatic genetic aberrations, which can lead to clinical cancer development. Autoantibodies can pass through the placenta and cause a great variety of developmental birth defects. One has to realize that phenomenon that appear in complex systems appear in a somewhat random fashion!

Those with autoimmune inflammatory disease experience difficulty healing. The slow- union or non-union of fractures, the slow healing of surgical sites with the development of keloids, incisional hernias, and adhesions are common in such a group. At times women, if they experience a high-grade autoimmune condition, can pass autoantibodies through the placenta and cause difficulty in embryological tissue-plane-merging and so cleft palate and spina bifida, among other developmental birth defects, can develop. This infectious disease and the autoimmunological response is much more common in “third world countries” such as Vietnam, and of course there are many missions to that country to repair cleft palate and developmental abnormalities to the heart, for instance.

Patients and clinicians notice abnormalities in the organs of special senses most commonly. The eyes develop cataracts, presbyopia, macular degeneration, glaucoma, retinal detachment, iritis, uveitis, penguecula development, diplopia, scleritis and choroiditis, etc. The hearing sense develops tinnitis, and decreased function. The vestibular nerve can malfunction and the individual may develop vertigo. The facial nerve abnormalities lead to Bell's palsey. Autoimmune trigeminal neuritis causes migraine headaches. Rheumatoid tempo-mandibular arthritis causes TMJ headaches and it is not unusual for both types of headaches to exist concomitantly since they are both caused by the same underlying autoimmune vasculitic condition.

Most people have heard about the risk factors of coronary artery disease: a positive family history of CAD, type A personality, high cholesterol, diabetes, hypertension, transverse ear lobe folds (an idea of about 15 years ago), and I will ad my own: neurological back pain: sciatica. The same risk factors fit for those with arteriolar aneurysms and peripheral vascular disease. The reality is that all the markers or risk factors are simply concomitant phenomena caused by the inflammatory, autoimmune disease about which I am writing. The positive family history is not due to genetics, it is because individuals within families are more likely to contract the infection in question, and therefore develop the autoimmune disease, more frequently.

I have been to Vietnam, Taiwan, and Mexico recently for extended periods and I know the underlying infectious disease and the autoimmune response is more severe and endemic in those more economically undeveloped locales than here, in America, and in Western Europe. The microorganism has been brought here, including various strains that are more pathological, and such importation has caused an increase in the commonality and severity of the autoimmune disease process, that is systemic in nature, and therefore the above conditions are more prevalent than, let us say, 30 years ago. There are other influences that have caused the infection and autoimmune response to be more prevalent, also.

Being a general practitioner, and having worked in the US Navy in the USA and overseas, or in small-town clinics all my professional life, so I have not published in academic journals. I did, however speak at the Second World Conference on Immune-Mediated Diseases in Moscow, last September. I was a substitute speaker, for I took the place of a Russian scientist who had had a heart attack, on an afternoon of one of the last days. I think most of the “listeners” were Russian pediatric allergists, since they sponsored the meeting. Most of the international “academics” had left since they were there, basically, to give their own talks. I am not sure if many of the Russians understood my “rapid English” since I only had twenty-five minutes to speak. Since this is a systemic disease process, it is naturally complex. For that reason I have written a book so that I can explain many more of the mechanisms of disease production in the various tissues and organs and how the underlying, systemic, inflammatory autoimmune disease plays the key role.

Most medical and scientific research, nowadays, is conducted via microscopic or submicroscopic means. The articles in the 2000, or so, medical journals printed in the world can attest to that fact. Most research findings do not really affect the practical advancement of medical science wherein the treatment of diseases is improved. My research was of a macroscopic, clinical and epidemiological nature. I used induction to reason out and see the relationships between the biological and clinical observations I have made being a physician. I have seen 230,000 patient interfaces and that comprises a great number of observations. I had a great setting, being an independent clinic owner, in a poor area, for nearly a quarter century. Poor people are sicker people, in general, and being a general practitioner, and treating all diseases, I “had a chance” to put the puzzle together.

Another advantage I had, perhaps, is that I am a former US Marine officer. I was a Phantom II pilot with 146 combat missions in the Vietnam War. While flying a high performance jet, I had to learn to integrate a great number of factors, simultaneously, and perhaps I became something of a systems analyst, at 500kts with people shooting at me! Marines have a saying, “the difficult we do immediately, and the impossible just takes a little longer.” Humorous, it is, but Tarawa, Iwo Jima, and other nasty places were dealt with successfully through perseverance more than intelligence. My investigation took a great amount of perseverance, an experienced knowledge of many disease entities, being located in one clinic for a long period, and I saw, medically, males and females of all ages and for all diseases. I had the perseverance and the sense of duty to my patients to work 12-14 hours a day for two and one-half years and eventually I “figured out” the puzzle, the enigma!

The next step in providing proper assurance that my theory is correct, is that I would need to connect with an investigative group that has a connection to a large hospital/clinic system and coordinate serology and inflammatory marker testing of cohorts of patients. Patients with: breast cancer, colon cancer, brain cancer, leukemia, diabetes, Cushing's syndrome, Addison's disease, Polycystic ovary disease, Parkinson's disease, Alzheimer's disease, arteriosclerosis, stroke, hypothyroidism, ulcerative colitis, chronic pain from fibromyalgia and neuropathies, esophagitis, ulcers, AIDS, TB, MRSA, the rheumatic diseases, Crohn's disease, gastric ulcers, etc.

Perhaps fifty of each type of patient could be enrolled in the serological study. Phlebotomies could be organized through the hospital and clinic via a contractual agreement and each patient or caretaker could sign a permission slip for the test. Such testing is quite simple to organize, I think. If the serology results are positive, like they were in my own clinic, that is, if something like 60% of patients have elevated serology, the theory is proven. Antibody levels drop, over time, if a patient does not have an infection in the intervening period, but the immune system is still operating in a pathological way, even if the antibodies, that are also autoantibodies, are at a lower level. The patient is still immunologically primed to respond aggressively to repeated infection in the future. This is what causes exacerbations of rheumatoid arthritis, for instance, and why back pain exacerbates: because the autoimmune disease improves, to some degree, if a person does not have an infection, by the organism in question, for a certain period, and then if a new infection takes place the inflammatory autoimmune disease will become worse.

A person could elect to do further testing on a greater number and on more varied cohorts of patients, in addition, to make the proof more firm. Once the theory is proven, the research can start in an effort to make autoantigen, autoantibody and target-tissue blocking agents. The first and last are probably similar. A group of medications from the existing pharmacopeia can be developed to inhibit the autoimmune response. I had many, many patients on a selection of medications that helped without question. A vaccine can be developed!

Many people die early in life from cancer, heart disease, and aneurysm formation, because they, more or less, age early. The individual organs that develop clinical abnormalities from the underlying, inflammatory, autoimmune disease exhibit them with some randomness, which would be natural in a complex system. It is quite common, however, for a person to have low back pain, an explosive or driven personality (Type A), some arthritis in the knee, and experience an arthroscopic surgical procedure. Then later, arthritis in the hands may appear and then age marks (seborrheic keratosis) develop. The individual might have had nevi and need to watch for malignant melanoma. After a few years they have a myocardial infarction or angina and have a stent emplaced. Perhaps later, they develop atrial fibrillation, and then ten years later they get cancer. The temporal appearance of the diseases mentioned above, which are really target –organ manifestations of an underlying autoimmune disease, and are in the sequence I noted in the members of families in my area, among others. One phenomenon that takes place, that we just take for granted, is that as we age we get ruddy faces and graying of the hair. Both are manifestations of the subtle, autoimmune, inflammatory disease that we all have! The universal physical changes that all humans experience, commonly termed aging, are, for sure, for the most part, the physical manifestations of this underlying infectious/autoimmune, inflammatory process.

Like all break-throughs in science, I was the receiver of millions of bits of knowledge from my mentors through the years and then from my own clinical experiences. All the bits of “passed-on” knowledge ( I sound like Bill Gates=bits of knowledge) and personal medical observations led to a generalization. Like many new insights it is simple once it is understood, like: E=MC sq. Even the visualization of the disease mentally, is somewhat akin to Einstein's heuristic thoughts that led to the theory of special relativity.

Einstein wrote, the simpler a theory, and the more observations it explains, the more likely it is to be correct (paraphrased). My theory is simple and it explains most of the puzzling observations I have had in medicine for over thirty years, and serological testing and the taking of medical histories proved it is correct.

James W. Goding, MD, Ph.D., Monash University, Australia, wrote in the epilogue of “The Autoimmune Diseases”, “Would the Real Autoantigen Please Stand Up!” He was referring to the concept that there was probably one autoantigen or group of antigens from one source that caused the autoimmune diseases listed in that long text. I have found it, I am very sure.

I know that many would think that I, being an sixty-eight year old osteopathic, general practitioner, may be one of the most unlikely medical professionals to develop a major insight in medicine! I was, however, the one independently seeing patients of both sexes, of all ages, for all diseases, in one community, for a long period, an unusual situation in medicine nowadays in the period of procedural, specialty-dominated medicine. In my setting, I alone had the responsibility to determine what was medically causing disease processes within my patients. I was an independent physician and worked in an economically poor area. I had the independence of thought, to determine what I have managed.

Also, one must realize that John Snow, a general physician in London, did an epidemiological study and determined that cholera was spread by water supplies before the microbiological theory was well developed. In addition, one must remember that Louis Pasteur and Claude Bernard were not connected to a research institute. One could consider that Walter Reed and his physician associates, Dr.Jesse Lazear and Dr. James Carroll, and even Dr. Carlos Findlay, the Cuban physician who advanced the theory that the mosquito transmitted yellow fever twenty years before Dr. Reed's research project, who together proved that Yellow Fever was spread via the mosquito, were simply general practice physicians. To tell you the truth, the division of medicine into specialties has harmed the discovery of disease processes because specialists, by concept and training, develop a constricted view of medical science and t times never see sick patients. Since this autoimmune disease presents primarily as a vasculitis, and since there are no vasculogists (a new word), no one would ever determine that people have a wide-spread, inflammatory, autoimmune, vasculitic disease!

To give you a better idea of how simple it is, just look in “Harrison's Principles of Internal Medicine, 16th Edition”, within the section that discusses rheumatoid arthritis. The information provided indicates that there is no known cause for rheumatoid arthritis (RA), and that it is a systemic, autoimmune disease that features arthritis, neuropathy, and vasculitis, and that it can cause organ infarction, even a myocardial infarction. Earlier editions (the 13th edition, for instance) also indicated that a feverish disease could cause an exacerbation of RA. Since myocardial infarctions are caused by arteriosclerosis, as a general disease process, other clinical manifestations are peripheral vascular disease, stroke, arterial aneurysms and venous abnormalities such as venous thrombosis. I just had to learn what caused the feverish disease that triggered exacerbations of RA, and put the puzzle together. Thereafter, I just had to add on the fact that most people who develop cancer have, at least, one of the rheumatological diseases, for instance rheumatoid arthritis, at least subtlety, and so there is no doubt that the rheumatoid diseases and cancer are caused by the same underlying autoimmune disease process.

Even Galen, the famous Greek physician, scientist and philosopher, in 200 AD, coined the word “rheumatism” because the word-root rheum means phlegm. He knew that respiratory infections that frequently caused expectoration (coughing up phlegm) and coryza (phlegm from the nose), led to a miserable, chronic condition in his patients. He termed it “rheumatismos” or in English, “rheumatism”. Yes, arteriosclerosis, cancer, the endocrine diseases, the rheumatoid diseases, peripheral and central neuropathies and many more conditions are part of the rheumatism concept. They are all end-organ manifestations of the systemic, autoimmune, inflammatory disease of rheumatism!

Philology, the science of language, has, over hundreds of years, incorporated a great amount of wisdom within itself . In the Webster's New Twentieth Century Dictionary, 1976, it mentions under the word rheumatism: “any of various painful conditions of the joints and muscles; especial y, a disease believed to be caused by a microorganism and characterized by inflammation and pain in the joints.”

The “nut” of my theory has been known for thousands of years, but now with added, more recent knowledge from bacteriology, immunology, and the autoimmune concept, and by thinking systemically, as I saw my patients, especially during the clinical, epidemiological investigation I have mentioned, the nature of the disease process let itself be known.

I have presented the case for a disease that is so common, since it is caused by a microorganism ubiquitous to the society of vertebrates, and the autoimmune, inflammatory affects so universal, that we all have it. You, me, my kids, my ex-wife, my neighbors (I know the family: Dad has Charcot-Marie-Toothe syndrome (high arches and neuropathy of the legs), a cardiac stent and then a CABG and between the two was in the hospital for 8 days for “pneumonia with complications”, which was really a disease episode from the organism in question. Both his sons have the disease quite meaningfully as they have chronic pain and peripheral neuropathies. All of us humans in the world have the disease, because the organism is so ubiquitous. Some people and families have it worse, naturally. Those individuals and families often do not function well in life.

Since I have finished a book of approximately 200 pages concerning this disease process I could naturally write on and on. I will not, however, but I will say this: Over the last fifteen years there has been a great increase in the number of cancer, fibromyalgia, chronic pain, and autistic patients and the appearance of many infections such as TB, syphlis, MRSA, etc., in the American scene, of which I am most familiar. There has also been special manifestations of diseases, psychological and physical, in military men returning from overseas duty, especially from Vietnam and the Middle East. The reason this is true, I believe, is that the pathogens that cause the diseases are more common in poor societies and we, by our war activities, make the disease more manifest in the civilians in the war zone and within our own troops. In addition, infections by the microorganism and therefore the autoimmune response has become more meaningful in American society due to the immigration of ten million people from Mexico and Southeast Asia. Frequent international air travel has introduced microorganisms, or more pathological strains of microorganisms, into our country also.

Hopefully, you have found this letter a little entertaining and interesting. I think I am correct concerning the principles of my theory. I have interviewed, medically, over two hundred and thirty thousand patients during 30 year practice period. I was a physician in medicine, with a wide interest and the responsibility for treating my patients with all medical problems. I practiced in an economically poor area, with quite a few Mexican immigrants, so the markers of disease appeared more overtly than in a more affluent community. I have proved my theory via serological testing. I spent nine months visiting nine countries to determine that this disease process is world-wide. I am presenting a new generalization in medicine, a unifying theory of most or many of the idiopathic disease entities that have filled medical books for decades. The guiding theory, and the pathological and immunological principles that support it, will enable medical scientists to “focus” on the cause of diseases (really target-organ manifestations of an underlying autoimmune disease) and not just try this or that random molecule via a clinical trial, to see if it works on this or that malady.

I have had trouble relaying my information to a research organization because I am semi-retired, sixty-eight, an osteopathic general practitioner, and not an allopathic physician, because I have never worked in a research organization and I have not had any research published. Really, I have found that most individuals, who are in investigative organizations, are typically comfortable dealing with professionals similar to themselves and are not overtly open to new ideas from a person not currently in the structured research industry. Naturally, I can understand such reluctance. The reality is, however, millions of researchers world-wide are usually working with a similar mental-set, using similar techniques and intellectual approaches, and the results of research leaves something to be desired since there have been no “major” breakthroughs detailing the cause of a major diseases in decades!

I am interested in collaborating with a research organization that can help further prove my theory and develop the pharmaceuticals needed to control the disease process. I think that the pharmaceuticals will surely be the most helpful to members of human society, and therefore the most profitable, in the history of medical treatment!

I have been a solo practitioner in a small town most of my medical career and have not associated with other physicians much. I have, however, an old professional and personal friend, Albert Mark, who I have known since I was 16, since I worked for him when he was an active pharmacist. His phone is 1-425-454-0300. His e-mail is: AMMark914@gmail.com . You are free to talk to him concerning me, my background, and my ethics. In addition, I still communicate with my anatomy professor from medical school, Jack Julyan, PhD. His e-mail is carol@julyan.org . He knew me quite well and he was a great teacher.
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Thanks for reading this letter. If you have any interest, please contact me at: ecnal-c@hotmail.com , or 360-864-4371. My address is PMB 227; 120 State Ave. NE, Olympia, Wa., 98501

Yours Truly,

Lance W. Christiansen, DO

Yours,

Lance Christiansen, DO.